pI: 7.1776 |
Length (AA): 532 |
MW (Da): 57172 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 532 | 4drs (A) | 23 | 526 | 99.99 | 0 | 1 | 2.10707 | -1.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Ortholog group members (OG5_126685)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G55810 | pyruvate kinase |
Arabidopsis thaliana | AT5G63680 | pyruvate kinase |
Arabidopsis thaliana | AT3G55650 | pyruvate kinase |
Arabidopsis thaliana | AT5G52920 | plastidial pyruvate kinase 2 |
Arabidopsis thaliana | AT5G08570 | pyruvate kinase |
Arabidopsis thaliana | AT3G25960 | pyruvate kinase |
Arabidopsis thaliana | AT3G04050 | pyruvate kinase |
Arabidopsis thaliana | AT1G32440 | plastidial pyruvate kinase 3 |
Arabidopsis thaliana | AT5G56350 | pyruvate kinase |
Arabidopsis thaliana | AT4G26390 | probable pyruvate kinase |
Babesia bovis | BBOV_III007000 | pyruvate kinase, putative |
Brugia malayi | Bm1_35910 | Pyruvate kinase, M2 isozyme |
Brugia malayi | Bm1_35895 | Pyruvate kinase, muscle isozyme |
Candida albicans | CaO19.11059 | pyruvate kinase |
Candida albicans | CaO19.3575 | pyruvate kinase |
Caenorhabditis elegans | CELE_F25H5.3 | Protein PYK-1, isoform A |
Cryptosporidium hominis | Chro.10234 | pyruvate kinase |
Cryptosporidium parvum | cgd1_2040 | pyruvate kinase |
Chlamydia trachomatis | CT_332 | pyruvate kinase |
Dictyostelium discoideum | DDB_G0283247 | phosphoenolpyruvate kinase |
Drosophila melanogaster | Dmel_CG7070 | Pyruvate kinase |
Escherichia coli | b1854 | pyruvate kinase II |
Escherichia coli | b1676 | pyruvate kinase I |
Echinococcus granulosus | EgrG_001001900 | pyruvate kinase |
Echinococcus granulosus | EgrG_001078100 | pyruvate kinase |
Entamoeba histolytica | EHI_098420 | pyruvate kinase, putative |
Echinococcus multilocularis | EmuJ_001078000 | pyruvate kinase |
Echinococcus multilocularis | EmuJ_001078100 | pyruvate kinase |
Echinococcus multilocularis | EmuJ_001001900 | pyruvate kinase |
Giardia lamblia | GL50803_17143 | Pyruvate kinase |
Homo sapiens | ENSG00000143627 | pyruvate kinase, liver and RBC |
Homo sapiens | ENSG00000067225 | pyruvate kinase, muscle |
Leishmania braziliensis | LbrM.34.0010 | pyruvate kinase |
Leishmania braziliensis | LbrM.34.0040 | pyruvate kinase |
Leishmania braziliensis | LbrM.34.0060 | pyruvate kinase |
Leishmania donovani | LdBPK_055450.1 | pyruvate kinase, putative |
Leishmania infantum | LinJ.35.5450 | pyruvate kinase |
Leishmania infantum | LinJ.35.0030 | pyruvate kinase |
Leishmania major | LmjF.35.0030 | pyruvate kinase |
Leishmania major | LmjF.35.0020 | pyruvate kinase |
Leishmania mexicana | LmxM.34.0030 | pyruvate kinase, putative |
Leishmania mexicana | LmxM.34.0020 | pyruvate kinase |
Loa Loa (eye worm) | LOAG_08496 | pyruvate kinase |
Loa Loa (eye worm) | LOAG_04101 | pyruvate kinase |
Loa Loa (eye worm) | LOAG_11357 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12831 | pyruvate kinase |
Loa Loa (eye worm) | LOAG_12029 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14898 | pyruvate kinase-PB |
Mycobacterium leprae | ML1277 | Probable pyruvate kinase PykA |
Mus musculus | ENSMUSG00000041237 | pyruvate kinase liver and red blood cell |
Mus musculus | ENSMUSG00000032294 | pyruvate kinase, muscle |
Mycobacterium tuberculosis | Rv1617 | Probable pyruvate kinase PykA |
Mycobacterium ulcerans | MUL_1598 | pyruvate kinase |
Neospora caninum | NCLIV_015200 | Pyruvate kinase (EC 2.7.1.40), related |
Oryza sativa | 4324263 | Os01g0276700 |
Oryza sativa | 4349454 | Os10g0571200 |
Oryza sativa | 4337406 | Os04g0677500 |
Onchocerca volvulus | OVOC593 | Pyruvate kinase homolog |
Onchocerca volvulus | OVOC9802 | Pyruvate kinase homolog |
Onchocerca volvulus | OVOC589 | Pyruvate kinase homolog |
Plasmodium berghei | PBANKA_1125600 | pyruvate kinase, putative |
Plasmodium falciparum | PF3D7_0626800 | pyruvate kinase |
Plasmodium knowlesi | PKNH_1123000 | pyruvate kinase, putative |
Plasmodium vivax | PVX_114445 | pyruvate kinase, putative |
Plasmodium yoelii | PY04645 | pyruvate kinase |
Saccharomyces cerevisiae | YAL038W | pyruvate kinase CDC19 |
Saccharomyces cerevisiae | YOR347C | pyruvate kinase PYK2 |
Schistosoma japonicum | Sjp_0201440 | ko:K00873 pyruvate kinase [EC2.7.1.40], putative |
Schistosoma japonicum | Sjp_0110140 | Pyruvate kinase isozyme R, putative |
Schistosoma mansoni | Smp_065610.2 | pyruvate kinase |
Schistosoma mansoni | Smp_065610.1 | pyruvate kinase |
Schmidtea mediterranea | mk4.004797.01 | Pyruvate kinase |
Schmidtea mediterranea | mk4.015045.03 | Pyruvate kinase |
Schmidtea mediterranea | mk4.001483.03 | Pyruvate kinase |
Schmidtea mediterranea | mk4.008681.02 | Pyruvate kinase |
Schmidtea mediterranea | mk4.004845.00 | |
Schmidtea mediterranea | mk4.015411.00 | |
Schmidtea mediterranea | mk4.005985.00 | Pyruvate kinase |
Schmidtea mediterranea | mk4.008681.00 | Pyruvate kinase |
Schmidtea mediterranea | mk4.015045.02 | Pyruvate kinase |
Schmidtea mediterranea | mk4.030887.00 | Pyruvate kinase |
Schmidtea mediterranea | mk4.005660.00 | Pyruvate kinase |
Schmidtea mediterranea | mk4.000329.00 | Pyruvate kinase |
Schmidtea mediterranea | mk4.008681.01 | Pyruvate kinase |
Schmidtea mediterranea | mk4.004797.06 | Pyruvate kinase |
Schmidtea mediterranea | mk4.011245.01 | Pyruvate kinase |
Trypanosoma brucei gambiense | Tbg972.10.16520 | pyruvate kinase 1, putative |
Trypanosoma brucei gambiense | Tbg972.10.16510 | pyruvate kinase 1, putative |
Trypanosoma brucei | Tb927.10.14140 | pyruvate kinase 1 |
Trypanosoma brucei | Tb11.v5.0605 | pyruvate kinase 1, putative |
Trypanosoma congolense | TcIL3000_10_12020 | pyruvate kinase 1, putative |
Trypanosoma cruzi | TcCLB.511281.60 | pyruvate kinase 2, putative |
Trypanosoma cruzi | TcCLB.507993.390 | pyruvate kinase 2, putative |
Toxoplasma gondii | TGME49_256760 | pyruvate kinase PyK1 |
Theileria parva | TP04_0607 | pyruvate kinase, putative |
Trichomonas vaginalis | TVAG_373720 | pyruvate kinase, putative |
Trichomonas vaginalis | TVAG_015950 | pyruvate kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14140 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14140 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14140 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14140 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1676 | Escherichia coli | non-essential | goodall |
b1854 | Escherichia coli | non-essential | goodall |
CELE_F25H5.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F25H5.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F25H5.3 | Caenorhabditis elegans | slow growth | wormbase |
YAL038W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1125600 | Plasmodium berghei | Essential | plasmo |
TGME49_256760 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania mexicana | pyruvate kinase, putative | Compounds | References |
Homo sapiens | pyruvate kinase, liver and RBC | Compounds | References |
Staphylococcus aureus (strain MRSA252) | Pyruvate kinase | Compounds | References |
Homo sapiens | pyruvate kinase, muscle | Compounds | References |