Detailed view for TcCLB.503521.50

Basic information

TDR Targets ID: 38245
Trypanosoma cruzi, UTP-glucose-1-phosphate uridylyltransferase 2, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.1973 | Length (AA): 482 | MW (Da): 53470 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01704   UTP--glucose-1-phosphate uridylyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0006011   UDP-glucose metabolic process  
GO:0003983   UTP:glucose-1-phosphate uridylyltransferase activity  
GO:0070569   GO:uridylyltransferase activity  

GO:0016779   nucleotidyltransferase activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 479 4m2a (A) 8 485 60.00 0 1 1.73515 -0.91
9 482 3gue (A) 8 482 68.00 0 1 1.8391 -0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128034)

Species Accession Gene Product
Arabidopsis thaliana AT5G17310   UTP--glucose-1-phosphate uridylyltransferase 1
Arabidopsis thaliana AT3G03250   UDP-GLUCOSE PYROPHOSPHORYLASE 1
Brugia malayi Bm1_41320   UDP-glucose pyrophosphorylase
Candida albicans CaO19.9305   similar to S. cerevisiae UGP1 (YKL035W) uridinephosphoglucose pyrophosphorylase involved in protein amino acid glycosylation
Candida albicans CaO19.1738   similar to S. cerevisiae UGP1 (YKL035W) uridinephosphoglucose pyrophosphorylase involved in protein amino acid glycosylation
Caenorhabditis elegans CELE_K08E3.5   Protein K08E3.5, isoform A
Dictyostelium discoideum DDB_G0277879   UDP-glucose pyrophosphorylase 2
Drosophila melanogaster Dmel_CG4347   CG4347 gene product from transcript CG4347-RE
Echinococcus granulosus EgrG_000193500   UTP glucose 1 phosphate uridylyltransferase
Echinococcus granulosus EgrG_000843500   UTP glucose 1 phosphate uridylyltransferase
Entamoeba histolytica EHI_000440   UDP-glucose pyrophosphorylase, putative
Echinococcus multilocularis EmuJ_000843500   UTP glucose 1 phosphate uridylyltransferase
Echinococcus multilocularis EmuJ_000193500   UTP glucose 1 phosphate uridylyltransferase
Giardia lamblia GL50803_29307   UTP-glucose-1-phosphate uridylyltransferase
Homo sapiens ENSG00000169764   UDP-glucose pyrophosphorylase 2
Leishmania braziliensis LbrM.18.1050   UDP-glucose pyrophosphorylase
Leishmania donovani LdBPK_180990.1   UDP-glucose pyrophosphorylase
Leishmania infantum LinJ.18.0990   UDP-glucose pyrophosphorylase
Leishmania major LmjF.18.0990   UDP-glucose pyrophosphorylase
Leishmania mexicana LmxM.18.0990   UTP-glucose-1-phosphate uridylyltransferase 2, putative
Loa Loa (eye worm) LOAG_16072   hypothetical protein
Loa Loa (eye worm) LOAG_06817   UDP-glucose pyrophosphorylase
Loa Loa (eye worm) LOAG_09471   hypothetical protein
Mus musculus ENSMUSG00000001891   UDP-glucose pyrophosphorylase 2
Oryza sativa 4328091   Os02g0117700
Oryza sativa 4347800   Os09g0553200
Saccharomyces cerevisiae YKL035W   UTP glucose-1-phosphate uridylyltransferase
Schistosoma japonicum Sjp_0043990   ko:K00963 UTP--glucose-1-phosphate uridylyltransferase [EC2.7.7.9], putative
Schistosoma mansoni Smp_133600   utp-glucose-1-phosphate uridylyltransferase 2 (udp-glucose pyrophosphorylase 2)
Schmidtea mediterranea mk4.001264.03  
Schmidtea mediterranea mk4.000070.17   UTPALQ-glucose-1-phosphate uridylyltransferase
Schmidtea mediterranea mk4.001264.04  
Schmidtea mediterranea mk4.000070.15  
Schmidtea mediterranea mk4.000070.19   UTPALQ-glucose-1-phosphate uridylyltransferase
Schmidtea mediterranea mk4.000090.06   UTPALQ-glucose-1-phosphate uridylyltransferase
Trypanosoma brucei gambiense Tbg972.10.15880   UTP-glucose-1-phosphate uridylyltransferase 2, putative
Trypanosoma brucei Tb927.10.13130   UTP-glucose-1-phosphate uridylyltransferase
Trypanosoma congolense TcIL3000_10_11210   UTP-glucose-1-phosphate uridylyltransferase 2, putative
Trypanosoma cruzi TcCLB.503521.50   UTP-glucose-1-phosphate uridylyltransferase 2, putative
Trypanosoma cruzi TcCLB.506359.60   UTP-glucose-1-phosphate uridylyltransferase 2, putative
Trichomonas vaginalis TVAG_518540   UDP- glucose pyrophosphorylase, putative
Trichomonas vaginalis TVAG_388260   utp-glucose-1-phosphate uridylyltransferase, putative
Trichomonas vaginalis TVAG_102390   utp-glucose-1-phosphate uridylyltransferase, putative
Trichomonas vaginalis TVAG_247480   UDP- glucose pyrophosphorylase, putative

Essentiality

TcCLB.503521.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08E3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_K08E3.5 Caenorhabditis elegans larval arrest wormbase
CELE_K08E3.5 Caenorhabditis elegans slow growth wormbase
YKL035W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Uridine-5'-Diphosphoglucose Pyrophosphorylase (2.7.7.9 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.503521.50 (Trypanosoma cruzi), UTP-glucose-1-phosphate uridylyltransferase 2, putative
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