pI: 8.5169 |
Length (AA): 287 |
MW (Da): 33394 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
36 | 143 | 5ufs (A) | 132 | 243 | 29.00 | 0.86 | 0.01 | 0.270307 | 1.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127859)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_08835 | Fatty acid elongation protein 3 |
Brugia malayi | Bm1_37910 | GNS1/SUR4 family protein |
Candida albicans | CaO19.908 | one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1) |
Candida albicans | CaO19.8526 | one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1) |
Caenorhabditis elegans | CELE_F56H11.4 | Protein ELO-1, isoform B |
Caenorhabditis elegans | CELE_D2024.3 | Protein ELO-3, isoform B |
Caenorhabditis elegans | CELE_C40H1.4 | Protein ELO-4 |
Cryptosporidium hominis | Chro.80534 | fatty-acyl elongase |
Cryptosporidium parvum | cgd8_4630 | 7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase |
Dictyostelium discoideum | DDB_G0292896 | GNS1/SUR4 family protein |
Dictyostelium discoideum | DDB_G0274669 | hypothetical protein |
Dictyostelium discoideum | DDB_G0272012 | GNS1/SUR4 family protein |
Dictyostelium discoideum | DDB_G0277569 | GNS1/SUR4 family protein |
Dictyostelium discoideum | DDB_G0281821 | steroid isomerase |
Drosophila melanogaster | Dmel_CG3971 | CG3971 gene product from transcript CG3971-RA |
Homo sapiens | ENSG00000170522 | ELOVL fatty acid elongase 6 |
Leishmania braziliensis | LbrM.14.0720 | fatty acid elongase, putative |
Leishmania braziliensis | LbrM.14.0630 | fatty acid elongase, putative |
Leishmania braziliensis | LbrM.14.0690 | fatty acid elongase, putative |
Leishmania donovani | LdBPK_140660.1 | fatty acid elongase, putative |
Leishmania donovani | LdBPK_140760.1 | fatty acid elongase, putative |
Leishmania donovani | LdBPK_140800.1 | fatty acid elongase, putative |
Leishmania infantum | LinJ.14.0760 | fatty acid elongase, putative |
Leishmania infantum | LinJ.14.0660 | fatty acid elongase, putative |
Leishmania infantum | LinJ.14.0800 | fatty acid elongase, putative |
Leishmania major | LmjF.14.0640 | fatty acid elongase, putative |
Leishmania major | LmjF.14.0740 | fatty acid elongase, putative |
Leishmania major | LmjF.14.0705 | fatty acid elongase, putative |
Leishmania mexicana | LmxM.14.0740 | fatty acid elongase, putative |
Leishmania mexicana | LmxM.14.0640 | fatty acid elongase, putative |
Leishmania mexicana | LmxM.14.0705 | fatty acid elongase, putative |
Loa Loa (eye worm) | LOAG_05719 | GNS1/SUR4 family protein |
Loa Loa (eye worm) | LOAG_11536 | fatty acid elongation protein 3 |
Mus musculus | ENSMUSG00000041220 | ELOVL family member 6, elongation of long chain fatty acids (yeast) |
Neospora caninum | NCLIV_008210 | GNS1/SUR4 family domain-containing protein, putative |
Neospora caninum | NCLIV_020350 | GNS1/SUR4 domain containing protein, related |
Plasmodium berghei | PBANKA_0820900 | long chain fatty acid elongation enzyme, putative |
Plasmodium falciparum | PF3D7_0920000 | long chain fatty acid elongation enzyme, putative |
Plasmodium falciparum | PF3D7_0109300 | fatty acid elongation protein, GNS1/SUR4 family, putative |
Plasmodium knowlesi | PKNH_0718000 | fatty acid elongase, putative |
Plasmodium vivax | PVX_099415 | GNS1/SUR4 domain containing protein |
Plasmodium yoelii | PY03060 | unnamed protein product, putative |
Plasmodium yoelii | PY05248 | 30 kDa glycoprotein |
Saccharomyces cerevisiae | YLR372W | fatty acid elongase SUR4 |
Saccharomyces cerevisiae | YJL196C | fatty acid elongase ELO1 |
Trypanosoma brucei gambiense | Tbg972.7.4690 | fatty acid elongase, putative |
Trypanosoma brucei | Tb927.7.4180 | Fatty acid elongase |
Trypanosoma congolense | TcIL3000_7_3360 | fatty acid elongase, putative |
Trypanosoma cruzi | TcCLB.506661.30 | fatty acid elongase, putative |
Trypanosoma cruzi | TcCLB.511245.130 | fatty acid elongase, putative |
Trypanosoma cruzi | TcCLB.511245.160 | fatty acid elongase, putative |
Trypanosoma cruzi | TcCLB.510989.10 | fatty acid elongase, putative |
Toxoplasma gondii | TGME49_253880 | GNS1/SUR4 family protein |
Toxoplasma gondii | TGME49_205350 | integral membrane protein, GNS1/SUR4 family protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4180 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.4180 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_D2024.3 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0820900 | Plasmodium berghei | Dispensable | plasmo |
TGME49_205350 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_253880 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_205350 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_253880 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Compounds | References |
Mus musculus | ELOVL family member 6, elongation of long chain fatty acids (yeast) | Compounds | References |