pI: 9.8763 |
Length (AA): 78 |
MW (Da): 9690 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 77 | 1qb3 (A) | 21 | 105 | 54.00 | 0 | 1 | 1.41 | 0.37 |
6 | 78 | 1cks (A) | 3 | 75 | 59.00 | 0 | 1 | 1.57 | 0.42 |
1 | 77 | 3qy2 (B) | 20 | 105 | 52.00 | 0 | 1 | 1.55178 | -0.89 |
6 | 75 | 5lqf (C) | 3 | 72 | 61.00 | 0 | 1 | 1.70204 | -1.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127469)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G27970 | cyclin-dependent kinases regulatory subunit 2 |
Arabidopsis thaliana | AT2G27960 | cyclin-dependent kinases regulatory subunit 1 |
Babesia bovis | BBOV_I002360 | hypothetical protein |
Brugia malayi | Bm1_10915 | Cyclin-dependent kinases regulatory subunit |
Candida albicans | CaO19.1282 | subunit of Cdc28 protein kinase |
Candida albicans | CaO19.8869 | subunit of Cdc28 protein kinase |
Caenorhabditis elegans | CELE_C09G4.3 | Protein CKS-1 |
Caenorhabditis elegans | CELE_Y71G12B.27 | Protein Y71G12B.27 |
Cryptosporidium parvum | cgd8_2510 | Cyclin dependent kinase regulatory subunit, putative |
Dictyostelium discoideum | DDB_G0271642 | cyclin-dependent kinases regulatory subunit |
Drosophila melanogaster | Dmel_CG3738 | Cyclin-dependent kinase subunit 30A |
Drosophila melanogaster | Dmel_CG9790 | Cyclin-dependent kinase subunit 85A |
Echinococcus granulosus | EgrG_000786500 | cyclin dependent kinases regulatory subunit |
Entamoeba histolytica | EHI_009405 | cyclin-dependent kinase regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000786500 | cyclin dependent kinases regulatory subunit |
Giardia lamblia | GL50803_2661 | Cyclin-dependent kinases regulatory subunit |
Homo sapiens | ENSG00000173207 | CDC28 protein kinase regulatory subunit 1B |
Homo sapiens | ENSG00000123975 | CDC28 protein kinase regulatory subunit 2 |
Leishmania braziliensis | LbrM.32.4030 | cyclin-dependent kinase regulatory subunit |
Leishmania donovani | LdBPK_323940.1 | cyclin-dependent kinase regulatory subunit |
Leishmania infantum | LinJ.32.3940 | cyclin-dependent kinase regulatory subunit |
Leishmania major | LmjF.32.3790 | cyclin-dependent kinase regulatory subunit |
Leishmania mexicana | LmxM.31.3790 | cyclin-dependent kinase regulatory subunit |
Loa Loa (eye worm) | LOAG_07171 | cyclin-dependent kinase regulatory subunit |
Mus musculus | 102643116 | cyclin-dependent kinases regulatory subunit 2-like |
Mus musculus | 102640775 | cyclin-dependent kinases regulatory subunit 1-like |
Mus musculus | 102641603 | cyclin-dependent kinases regulatory subunit 2-like |
Mus musculus | 102638700 | cyclin-dependent kinases regulatory subunit 2-like |
Mus musculus | ENSMUSG00000062248 | CDC28 protein kinase regulatory subunit 2 |
Mus musculus | ENSMUSG00000028044 | CDC28 protein kinase 1b |
Mus musculus | 624855 | CDC28 protein kinase 1b, retrogene |
Neospora caninum | NCLIV_060780 | hypothetical protein |
Neospora caninum | NCLIV_061380 | hypothetical protein |
Oryza sativa | 4331610 | Os03g0146300 |
Onchocerca volvulus | OVOC13507 |
|
Saccharomyces cerevisiae | YBR135W | Cks1p |
Schistosoma japonicum | Sjp_0055240 | ko:K02219 cyclin-dependent kinase regulatory subunit CKS1, putative |
Schistosoma mansoni | Smp_158910 | hypothetical protein |
Schmidtea mediterranea | mk4.001305.00 | Cyclin-dependent kinases regulatory subunit |
Trypanosoma brucei gambiense | Tbg972.11.18430 | cyclin dependant kinases regulatory subunit, putative |
Trypanosoma brucei | Tb927.11.16390 | cyclin dependent kinases regulatory subunit, putative |
Trypanosoma cruzi | TcCLB.425969.9 | cyclin-dependent kinases regulatory subunit, putative |
Trypanosoma cruzi | TcCLB.511529.68 | cyclin-dependent kinases regulatory subunit, putative |
Toxoplasma gondii | TGME49_219100 | cyclin-dependent kinase regulatory subunit protein |
Theileria parva | TP01_1189 | hypothetical protein |
Trichomonas vaginalis | TVAG_142260 | cyclin-dependent kinases regulatory subunit, putative |
Trichomonas vaginalis | TVAG_164620 | cyclin-dependent kinases regulatory subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.8085 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.8085 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.8085 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.8085 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C09G4.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_C09G4.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y71G12B.27 | Caenorhabditis elegans | embryonic lethal | wormbase |
YBR135W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_219100 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | CDC28 protein kinase regulatory subunit 1B | Compounds | References |