pI: 8.6524 |
Length (AA): 471 |
MW (Da): 52803 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
96 | 411 | 2bq8 (X) | 1 | 302 | 26.00 | 0 | 1 | 0.64 | -0.65 |
96 | 402 | 2bq8 (X) | 1 | 294 | 28.00 | 0 | 1 | 0.97 | -0.79 |
96 | 405 | 1qfc (A) | 3 | 299 | 25.00 | 0 | 1 | 0.819474 | 0.18 |
97 | 405 | 2bq8 (X) | 2 | 297 | 25.00 | 0 | 1 | 0.898351 | -0.53 |
102 | 336 | 5uq6 (A) | 9 | 226 | 34.00 | 0 | 1 | 0.631338 | 0.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129627)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G01880 | purple acid phosphatase 7 |
Arabidopsis thaliana | AT2G01890 | purple acid phosphatase 8 |
Arabidopsis thaliana | AT3G17790 | purple acid phosphatase 17 |
Arabidopsis thaliana | AT1G14700 | purple acid phosphatase 3 |
Arabidopsis thaliana | AT1G25230 | Calcineurin-like metallo-phosphoesterase superfamily protein |
Babesia bovis | BBOV_I004700 | acid phosphatase, putative |
Brugia malayi | Bm1_48715 | Ser/Thr protein phosphatase family protein |
Caenorhabditis elegans | CELE_F02E9.7 | Protein F02E9.7 |
Cryptosporidium hominis | Chro.70489 | hypothetical protein |
Cryptosporidium hominis | Chro.20071 | hypothetical protein |
Cryptosporidium parvum | cgd2_640 | possible conserved acid phosphatase |
Cryptosporidium parvum | cgd7_4420 | secreted acid phosphatase (calcineurin family),signal peptide |
Homo sapiens | ENSG00000102575 | acid phosphatase 5, tartrate resistant |
Loa Loa (eye worm) | LOAG_02585 | hypothetical protein |
Mus musculus | ENSMUSG00000001348 | acid phosphatase 5, tartrate resistant |
Neospora caninum | NCLIV_061160 | acid phosphatase, putative |
Neospora caninum | NCLIV_006570 | serine/threonine protein phosphatase, putative |
Oryza sativa | 4347989 | Os10g0116800 |
Oryza sativa | 9270602 | Os11g0549615 |
Oryza sativa | 4332195 | Os03g0238600 |
Oryza sativa | 9266367 | Os11g0549620 |
Plasmodium berghei | PBANKA_0819000 | glideosome-associated protein 50, putative |
Plasmodium falciparum | PF3D7_0918000 | glideosome-associated protein 50 |
Plasmodium knowlesi | PKNH_0716000 | glideosome-associated protein 50, putative |
Plasmodium vivax | PVX_099320 | glideosome-associated protein 50, putative |
Plasmodium yoelii | PY05000 | hypothetical protein |
Schmidtea mediterranea | mk4.004442.00 | Tartrate-resistant acid phosphatase type 5 |
Trypanosoma cruzi | TcCLB.507747.230 | acid phosphatase type 5, putative |
Trypanosoma cruzi | TcCLB.503723.60 | tartrate-resistant acid phosphatase type 5 precursor, putative |
Toxoplasma gondii | TGME49_219320 | acid phosphatase GAP50 |
Theileria parva | TP03_0512 | acid phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0819000 | Plasmodium berghei | Essential | plasmo |
TGME49_219320 | Toxoplasma gondii | Probably essential | sidik |
TGME49_219320 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
65 literature references were collected for this gene.