pI: 8.3826 |
Length (AA): 381 |
MW (Da): 43032 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
54 | 381 | 2bfd (B) | 14 | 341 | 61.00 | 0 | 1 | 1.68 | -1.83 |
61 | 380 | 1umd (B) | 4 | 322 | 45.00 | 0 | 1 | 1.56 | -1.84 |
52 | 380 | 2bfd (B) | 3 | 340 | 60.00 | 0 | 1 | 1.63462 | -0.89 |
61 | 380 | 1umd (B) | 4 | 322 | 45.00 | 0 | 1 | 1.48769 | -1.02 |
61 | 381 | 1qs0 (B) | 6 | 338 | 45.00 | 0 | 1 | 1.39432 | -0.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, late schizont, Oocyst, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, late trophozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, merozoite, early trophozoite, Ring, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Sporozoite. | Zanghi G |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_128323)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G55510 | branched-chain alpha-keto acid decarboxylase E1 beta subunit |
Arabidopsis thaliana | AT3G13450 | branched chain alpha-keto acid dehydrogenase E1 beta |
Babesia bovis | BBOV_IV008190 | branched-chain alpha-keto acid dehydrogenase E1 component beta subunit, putative |
Brugia malayi | Bm1_56495 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor |
Caenorhabditis elegans | CELE_F27D4.5 | Protein TAG-173 |
Chlamydia trachomatis | CT_340 | oxoisovalerate dehydrogenase subunits alpha/beta |
Dictyostelium discoideum | DDB_G0268020 | 3-methyl-2-oxobutanoate dehydrogenase |
Drosophila melanogaster | Dmel_CG17691 | CG17691 gene product from transcript CG17691-RC |
Homo sapiens | ENSG00000083123 | branched chain keto acid dehydrogenase E1, beta polypeptide |
Leishmania braziliensis | LbrM.34.0090 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Leishmania donovani | LdBPK_350050.1 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Leishmania infantum | LinJ.35.0050 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Leishmania major | LmjF.35.0050 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Leishmania mexicana | LmxM.34.0050 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Loa Loa (eye worm) | LOAG_04489 | 2-oxoisovalerate dehydrogenase subunit beta |
Mus musculus | ENSMUSG00000032263 | branched chain ketoacid dehydrogenase E1, beta polypeptide |
Mycobacterium tuberculosis | Rv2496c | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB |
Mycobacterium ulcerans | MUL_3774 | pyruvate dehydrogenase E1 component subunit PdhB |
Neospora caninum | NCLIV_057460 | Transketolase central region, related |
Oryza sativa | 4342508 | Os07g0170100 |
Plasmodium berghei | PBANKA_1104200 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative |
Plasmodium falciparum | PF3D7_0504600 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative |
Plasmodium knowlesi | PKNH_1029000 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative |
Plasmodium vivax | PVX_097790 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative |
Plasmodium yoelii | PY03843 | Drosophila melanogaster RE25729p |
Schmidtea mediterranea | mk4.017287.00 | |
Schmidtea mediterranea | mk4.004369.02 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.10.5390 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Trypanosoma brucei | Tb10.v4.0043 | chrX additional, unordered contigs |
Trypanosoma brucei | Tb927.10.4330 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Trypanosoma congolense | TcIL3000_10_3620 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Trypanosoma cruzi | TcCLB.511469.100 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Trypanosoma cruzi | TcCLB.506295.160 | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative |
Toxoplasma gondii | TGME49_314400 | pyruvate dehydrogenase E1 component, beta subunit, putative |
Theileria parva | TP01_0956 | pyruvate dehydrogenase E1 component beta subunit, mitochondrial, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2539 | Mycobacterium tuberculosis | non-essential | nmpdr |
CELE_F27D4.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F27D4.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F27D4.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1104200 | Plasmodium berghei | Slow | plasmo |
TGME49_314400 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Vigna radiata var. radiata | Pyruvate dehydrogenase complex | 359 aa | 34.0% | 326 aa | Compounds | References |
Pisum sativum | Pyruvate dehydrogenase complex | 359 aa | 34.0% | 326 aa | Compounds | References |
3 literature references were collected for this gene.