Detailed view for TcCLB.506389.79

Basic information

TDR Targets ID: 41085
Trypanosoma cruzi, calmodulin, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 3.6492 | Length (AA): 85 | MW (Da): 9498 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 85 2f33 (A) 1 102 29.00 0 1 1.2 -0.55
4 85 2f3y (A) 3 84 90.00 0 1 2.14 -1.87
10 82 1gjy (A) 102 172 21.00 0.000006 1 1.4 -2.72
1 85 4djc (A) 1 85 91.00 0 1 2.246 -2.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126800)

Species Accession Gene Product
Arabidopsis thaliana AT5G21274   calmodulin 6
Arabidopsis thaliana AT2G41110   calmodulin 2
Arabidopsis thaliana AT3G56800   calmodulin 3
Arabidopsis thaliana AT1G66410   calmodulin 4
Arabidopsis thaliana AT3G43810   calmodulin 7
Arabidopsis thaliana AT2G27030   calmodulin 5
Babesia bovis BBOV_I004080   calmodulin
Brugia malayi Bm1_50415   calmodulin
Candida albicans CaO19.4413   likely calmodulin 3' exon
Candida albicans CaO19.11891   likely calmodulin 3' exon
Caenorhabditis elegans CELE_T21H3.3   Protein CMD-1
Cryptosporidium hominis Chro.20092   calmodulin
Cryptosporidium parvum cgd2_810   calmodulin
Dictyostelium discoideum DDB_G0279407   hypothetical protein
Drosophila melanogaster Dmel_CG8472   Calmodulin
Echinococcus granulosus EgrG_000491400   CalModulin family member cmd 1
Echinococcus granulosus EgrG_000532700   calmodulin
Echinococcus granulosus EgrG_000889000   calmodulin
Echinococcus granulosus EgrG_000605300   calmodulin
Echinococcus granulosus EgrG_000344500   calmodulin
Entamoeba histolytica EHI_100270   calmodulin, putative
Echinococcus multilocularis EmuJ_000747100   calmodulin
Echinococcus multilocularis EmuJ_000344500   calmodulin
Echinococcus multilocularis EmuJ_000490200   calmodulin
Echinococcus multilocularis EmuJ_000605300   calmodulin
Echinococcus multilocularis EmuJ_000532700   calmodulin
Echinococcus multilocularis EmuJ_000889000   calmodulin
Echinococcus multilocularis EmuJ_000491400   CalModulin family member (cmd 1)
Giardia lamblia GL50803_5333   Calmodulin
Homo sapiens ENSG00000160014   calmodulin 3 (phosphorylase kinase, delta)
Homo sapiens ENSG00000143933   calmodulin 2 (phosphorylase kinase, delta)
Homo sapiens ENSG00000198668   calmodulin 1 (phosphorylase kinase, delta)
Homo sapiens 810   calmodulin-like 3
Leishmania braziliensis LbrM.09.0970   calmodulin, putative
Leishmania braziliensis LbrM.09.0960   calmodulin, putative
Leishmania braziliensis LbrM.09.0980   calmodulin, putative
Leishmania donovani LdBPK_090980.1   calmodulin, putative
Leishmania donovani LdBPK_090970.1   calmodulin, putative
Leishmania infantum LinJ.09.0970   calmodulin, putative
Leishmania infantum LinJ.09.0980   calmodulin, putative
Leishmania major LmjF.09.0920   calmodulin, putative
Leishmania major LmjF.09.0910   calmodulin, putative
Leishmania major LmjF.09.0930   calmodulin, putative
Leishmania mexicana LmxM.09.0910   calmodulin, putative
Leishmania mexicana LmxM.09.0930   calmodulin, putative
Leishmania mexicana LmxM.09.0920   calmodulin, putative
Loa Loa (eye worm) LOAG_01388   hypothetical protein
Mus musculus ENSMUSG00000063130   calmodulin-like 3
Mus musculus ENSMUSG00000019370   calmodulin 3
Mus musculus ENSMUSG00000036438   calmodulin 2
Mus musculus ENSMUSG00000001175   calmodulin 1
Neospora caninum NCLIV_065440   hypothetical protein
Oryza sativa 4332664   Os03g0319300
Oryza sativa 4324384   Os01g0267900
Oryza sativa 4344344   Os07g0687200
Oryza sativa 4339172   Os05g0491100
Oryza sativa 4326903   Os01g0279300
Oryza sativa 4325693   Os01g0135700
Oryza sativa 9270836   Os03g0715600
Onchocerca volvulus OVOC7165  
Onchocerca volvulus OVOC7077   Calmodulin homolog
Plasmodium berghei PBANKA_1010600   calmodulin, putative
Plasmodium falciparum PF3D7_1434200   calmodulin
Plasmodium knowlesi PKNH_0420800   calmodulin, putative
Plasmodium vivax PVX_084825   calmodulin, putative
Plasmodium yoelii PY06908   calmodulin
Saccharomyces cerevisiae YBR109C   calmodulin
Schistosoma japonicum Sjp_0211700   ko:K02183 calmodulin, putative
Schistosoma japonicum Sjp_0306580   Calmodulin, putative
Schistosoma mansoni Smp_026560.2   calmodulin
Schmidtea mediterranea mk4.000167.16   Calmodulin
Schmidtea mediterranea mk4.001174.04   Calmodulin
Schmidtea mediterranea mk4.004858.01   Calmodulin
Schmidtea mediterranea mk4.020243.00   Calmodulin-like protein 3
Schmidtea mediterranea mk4.000046.23  
Schmidtea mediterranea mk4.014755.00  
Schmidtea mediterranea mk4.024912.01  
Schmidtea mediterranea mk4.008639.00  
Schmidtea mediterranea mk4.010122.01  
Schmidtea mediterranea mk4.003231.01  
Schmidtea mediterranea mk4.004517.00   Calmodulin-like protein 4
Schmidtea mediterranea mk4.002397.03  
Trypanosoma brucei gambiense Tbg972.11.14490   calmodulin, putative
Trypanosoma brucei gambiense Tbg972.11.14500   calmodulin, putative
Trypanosoma brucei gambiense Tbg972.11.14520   calmodulin, putative
Trypanosoma brucei gambiense Tbg972.11.14480  
Trypanosoma brucei gambiense Tbg972.11.14510   calmodulin, putative
Trypanosoma brucei Tb927.11.13050   calmodulin
Trypanosoma brucei Tb927.11.13030   calmodulin
Trypanosoma brucei Tb927.11.13040   calmodulin
Trypanosoma brucei Tb927.11.13020   calmodulin
Trypanosoma cruzi TcCLB.506391.10   calmodulin
Trypanosoma cruzi TcCLB.506391.20   calmodulin, putative
Trypanosoma cruzi TcCLB.506389.79   calmodulin, putative
Trypanosoma cruzi TcCLB.507483.30   calmodulin, putative
Trypanosoma cruzi TcCLB.507483.39   calmodulin
Toxoplasma gondii TGME49_249240   calmodulin, putative
Theileria parva TP02_0717   calmodulin, putative
Trichomonas vaginalis TVAG_038070   calmodulin, putative

Essentiality

TcCLB.506389.79 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4621 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.4621 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.4621 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4621 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T21H3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T21H3.3 Caenorhabditis elegans slow growth wormbase
CELE_T21H3.3 Caenorhabditis elegans sterile wormbase
YBR109C Saccharomyces cerevisiae inviable yeastgenome
TGME49_249240 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Calmodulin Compounds References
Homo sapiens calmodulin 2 (phosphorylase kinase, delta) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.004 1 0.5
0.0038 0.5 0.5
0.0039 0.254 0.5
0.0038 0.5 0.5
0.003 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506389.79 (Trypanosoma cruzi), calmodulin, putative
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