Detailed view for TcCLB.511003.60

Basic information

TDR Targets ID: 41572
Trypanosoma cruzi, acetyl-CoA acetyltransferase, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 8.2786 | Length (AA): 396 | MW (Da): 42444 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00108   Thiolase, N-terminal domain
PF02803   Thiolase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016747   transferase activity, transferring groups other than amino-acyl groups  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 395 1wl4 (A) 6 397 36.00 0 1 1.4 -0.9
3 393 1ulq (A) 3 398 35.00 0 1 1.49 -0.75
1 392 4e1l (A) 1 390 36.00 0 1 1.4608 -0.49
1 393 2ib8 (A) 39 424 36.00 0 1 1.40132 -0.27
4 391 2iik (A) 38 419 39.00 0 1 1.3987 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126757)

Species Accession Gene Product
Arabidopsis thaliana AT5G47720   acetoacetyl-CoA thiolase 1
Arabidopsis thaliana AT5G48230   acetoacetyl-CoA thiolase 2
Babesia bovis BBOV_I002980   thiolase, N-terminal and C-terminal domain containing protein
Brugia malayi Bm1_21865   acetyl-CoA acyltransferases family protein
Candida albicans CaO19.1591   similar to Acetoacetyl-CoA Thiolase A
Caenorhabditis elegans CELE_T02G5.8   Protein KAT-1
Caenorhabditis elegans CELE_T02G5.7   Protein T02G5.7
Caenorhabditis elegans CELE_F53A2.7   Protein F53A2.7
Dictyostelium discoideum DDB_G0271544   acetoacetyl-CoA thiolase
Drosophila melanogaster Dmel_CG10932   CG10932 gene product from transcript CG10932-RB
Drosophila melanogaster Dmel_CG4600   yippee interacting protein 2
Drosophila melanogaster Dmel_CG9149   CG9149 gene product from transcript CG9149-RA
Escherichia coli b2224   acetyl-CoA acetyltransferase
Escherichia coli b2844   short chain acyltransferase
Echinococcus granulosus EgrG_000976900   acetyl coenzyme A acetyltransferase cytosolic
Echinococcus multilocularis EmuJ_000976900   acetyl coenzyme A acetyltransferase, cytosolic
Echinococcus multilocularis EmuJ_000976800   acetyl coenzyme A C acetyltransferase
Giardia lamblia GL50803_3287   Acetyl-CoA acetyltransferase
Homo sapiens 39   acetyl-CoA acetyltransferase 2
Homo sapiens 10449   acetyl-CoA acyltransferase 2
Homo sapiens ENSG00000075239   acetyl-CoA acetyltransferase 1
Loa Loa (eye worm) LOAG_05273   acetyl-CoA acyltransferase
Mycobacterium leprae ML1158   PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4 (ACETOACETYL-CoA THIOLASE)
Mus musculus ENSMUSG00000036880   acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Mus musculus ENSMUSG00000032047   acetyl-Coenzyme A acetyltransferase 1
Mus musculus ENSMUSG00000062480   acetyl-Coenzyme A acetyltransferase 3
Mus musculus ENSMUSG00000023832   acetyl-Coenzyme A acetyltransferase 2
Mycobacterium tuberculosis Rv1323   Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase)
Mycobacterium ulcerans MUL_3938   acetyl-CoA acetyltransferase
Mycobacterium ulcerans MUL_0357   beta-ketoacyl CoA thiolase
Neospora caninum NCLIV_069850   hypothetical protein
Oryza sativa 4346520   Os09g0252100
Oryza sativa 4326136   Os01g0110400
Plasmodium berghei PBANKA_1314600   acetyl-CoA acetyltransferase, putative
Plasmodium falciparum PF3D7_1450900   acetyl-CoA acetyltransferase, putative
Plasmodium knowlesi PKNH_1231200   acetyl-CoA acetyltransferase, putative
Plasmodium vivax PVX_117935   acetyl-CoA acetyltransferase, putative
Plasmodium yoelii PY01991   acetyl-coa acetyltransferase
Saccharomyces cerevisiae YPL028W   acetyl-CoA C-acetyltransferase
Schistosoma japonicum Sjp_0214830   Golgin subfamily A member 7, putative
Schistosoma japonicum Sjp_0049670   Nucleosome-remodeling factor subunit NURF301, putative
Schistosoma japonicum Sjp_0081390   ko:K00626 acetyl-CoA C-acetyltransferase [EC2.3.1.9], putative
Schistosoma mansoni Smp_129330   acetyl-CoA C-acetyltransferase
Schmidtea mediterranea mk4.002054.00   Acetyl-CoA C-acetyltransferase
Schmidtea mediterranea mk4.002169.05   HL08109p
Schmidtea mediterranea mk4.004278.03   Acetyl-CoA acetyltransferase, mitochondrial
Schmidtea mediterranea mk4.000144.09   Acetyl-CoA acetyltransferase, mitochondrial
Schmidtea mediterranea mk4.006024.01   Acetyl-CoA acetyltransferase, mitochondrial
Schmidtea mediterranea mk4.010354.01   Acetyl-CoA acetyltransferase, mitochondrial
Schmidtea mediterranea mk4.001907.03   3-ketoacyl-CoA thiolase, mitochondrial
Trypanosoma cruzi TcCLB.511003.60   acetyl-CoA acetyltransferase, putative
Toxoplasma gondii TGME49_301120   acetyl-CoA acetyltransferase
Trichomonas vaginalis TVAG_258280   acetyl-CoA acetyltransferase 2, putative
Trichomonas vaginalis TVAG_083530   acetyl-CoA C-acyltransferase, putative

Essentiality

TcCLB.511003.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2224 Escherichia coli non-essential goodall
b2844 Escherichia coli non-essential goodall
CELE_T02G5.7 Caenorhabditis elegans slow growth wormbase
YPL028W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1314600 Plasmodium berghei Essential plasmo
TGME49_301120 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511003.60 (Trypanosoma cruzi), acetyl-CoA acetyltransferase, putative
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