Detailed view for TcCLB.487507.10

Basic information

TDR Targets ID: 41978
Trypanosoma cruzi, tryparedoxin peroxidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.6852 | Length (AA): 199 | MW (Da): 22404 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00578   AhpC/TSA family
PF10417   C-terminal domain of 1-Cys peroxiredoxin

Gene Ontology

Mouse over links to read term descriptions.
GO:0051920   peroxiredoxin activity  
GO:0016491   oxidoreductase activity  
GO:0016209   antioxidant activity  
GO:0055114   oxidation reduction  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

Glutathione metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 1UUL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4LLR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126593)

Species Accession Gene Product
Arabidopsis thaliana AT5G06290   2-cysteine peroxiredoxin B
Arabidopsis thaliana AT3G11630   2-Cys peroxiredoxin BAS1
Arabidopsis thaliana AT1G48130   1-Cys peroxiredoxin PER1
Babesia bovis BBOV_I004500   antioxidant, AhpC/TSA family
Babesia bovis BBOV_II004970   thioredoxin peroxidase-like protein
Brugia malayi Bm1_37805   thioredoxin peroxidase 1
Brugia malayi Bm1_33935   thioredoxin peroxidase, identical
Brugia malayi Bm1_37710   Thioredoxin peroxidase 1
Brugia malayi Bm1_37795   AhpC/TSA family protein
Candida albicans CaO19.5180   similar to S. cerevisiae PRX1 (YBL064C) mitochondrial isoform of thioredoxin peroxidase
Candida albicans CaO19.7417   similar to S. cerevisiae TSA1 (YML028W) and TSA2 (YDR453C) thioredoxin peroxidase
Candida albicans CaO19_5180   hypothetical protein
Candida albicans CaO19.12647   similar to S. cerevisiae PRX1 (YBL064C) mitochondrial isoform of thioredoxin peroxidase
Caenorhabditis elegans CELE_Y38C1AA.11   Protein PRDX-6
Caenorhabditis elegans CELE_F09E5.15   Protein PRDX-2, isoform A
Caenorhabditis elegans CELE_R07E5.2   Protein PRDX-3
Cryptosporidium hominis Chro.40093   thioredoxin peroxidase
Cryptosporidium parvum cgd4_740   thioredoxin peroxidase-like protein
Chlamydia trachomatis CT_603   thio-specific antioxidant peroxidase
Dictyostelium discoideum DDB_G0274859   thioredoxin peroxidase
Dictyostelium discoideum DDB_G0282517   AhpC/TSA family protein
Drosophila melanogaster Dmel_CG6888   CG6888 gene product from transcript CG6888-RA
Drosophila melanogaster Dmel_CG12896   CG12896 gene product from transcript CG12896-RA
Drosophila melanogaster Dmel_CG5826   Peroxiredoxin 3
Drosophila melanogaster Dmel_CG1274   thioredoxin peroxidase 2
Drosophila melanogaster Dmel_CG3083   Peroxiredoxin 6005
Drosophila melanogaster Dmel_CG12405   Peroxiredoxin 2540-1
Drosophila melanogaster Dmel_CG11765   Peroxiredoxin 2540-2
Drosophila melanogaster Dmel_CG1633   thioredoxin peroxidase 1
Escherichia coli b0605   alkyl hydroperoxide reductase, C22 subunit
Echinococcus granulosus EgrG_000791700   thioredoxin peroxidase
Echinococcus granulosus EgrG_000913300   thioredoxin dependent peroxide reductase
Echinococcus granulosus EgrG_000791600   Peroxiredoxin 2
Entamoeba histolytica EHI_123390   peroxiredoxin
Entamoeba histolytica EHI_001420   peroxiredoxin
Entamoeba histolytica EHI_122310   peroxiredoxin
Entamoeba histolytica EHI_145840   peroxiredoxin
Entamoeba histolytica EHI_061980   peroxiredoxin
Entamoeba histolytica EHI_114010   peroxiredoxin
Entamoeba histolytica EHI_201250   peroxiredoxin
Echinococcus multilocularis EmuJ_000791600   Peroxiredoxin 2
Echinococcus multilocularis EmuJ_000913300   thioredoxin dependent peroxide reductase
Echinococcus multilocularis EmuJ_000791700   thioredoxin peroxidase
Giardia lamblia GL50803_14521   Peroxiredoxin 1
Giardia lamblia GL50803_15383   Peroxiredoxin 1
Giardia lamblia GL50803_16076   Peroxiredoxin 1
Homo sapiens ENSG00000167815   peroxiredoxin 2
Homo sapiens ENSG00000123131   peroxiredoxin 4
Homo sapiens ENSG00000117450   peroxiredoxin 1
Homo sapiens ENSG00000165672   peroxiredoxin 3
Homo sapiens ENSG00000117592   peroxiredoxin 6
Leishmania braziliensis LbrM.23.0050   peroxidoxin
Leishmania braziliensis LbrM.15.1100   tryparedoxin peroxidase
Leishmania braziliensis LbrM.15.1080   tryparedoxin peroxidase
Leishmania donovani LdBPK_230050.1   peroxidoxin
Leishmania donovani LdBPK_151140.1   tryparedoxin peroxidase
Leishmania donovani LdBPK_151120.1   tryparedoxin peroxidase
Leishmania infantum LinJ.15.1120   tryparedoxin peroxidase
Leishmania infantum LinJ.23.0050   peroxidoxin
Leishmania infantum LinJ.15.1140   tryparedoxin peroxidase
Leishmania infantum LinJ.15.1100   tryparedoxin peroxidase
Leishmania major LmjF.15.1100   tryparedoxin peroxidase
Leishmania major LmjF.15.1140   tryparedoxin peroxidase
Leishmania major LmjF.15.1160   tryparedoxin peroxidase
Leishmania major LmjF.15.1120   tryparedoxin peroxidase
Leishmania major LmjF.23.0040   peroxidoxin
Leishmania major LmjF.15.1080   tryparedoxin peroxidase
Leishmania major LmjF.15.1040   tryparedoxin peroxidase
Leishmania major LmjF.15.1060   tryparedoxin peroxidase
Leishmania mexicana LmxM.23.0040   peroxidoxin,tryparedoxin peroxidase
Leishmania mexicana LmxM.15.1040   tryparedoxin peroxidase
Loa Loa (eye worm) LOAG_02289   thioredoxin peroxidase 1
Loa Loa (eye worm) LOAG_01338   thioredoxin peroxidase
Mycobacterium leprae ML2042   ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C)
Mus musculus 21672   peroxiredoxin 2
Mus musculus ENSMUSG00000025289   peroxiredoxin 4
Mus musculus 18477   peroxiredoxin 1
Mus musculus ENSMUSG00000050114   peroxiredoxin 6B
Mus musculus 102642619   peroxiredoxin-6-like
Mus musculus ENSMUSG00000026701   peroxiredoxin 6
Mus musculus ENSMUSG00000024997   peroxiredoxin 3
Mycobacterium tuberculosis Rv2428   Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C)
Mycobacterium tuberculosis Rv2238c   Probable peroxiredoxin AhpE
Mycobacterium ulcerans MUL_2912   alkyl hydroperoxide reductase C protein AhpC
Mycobacterium ulcerans MUL_2999   alkyl hydroperoxide reductase C protein AhpC
Mycobacterium ulcerans MUL_1311   peroxiredoxin AhpE
Neospora caninum NCLIV_062630   Thioredoxin-dependent peroxide reductase, mitochondrial, related
Neospora caninum NCLIV_053640   peroxidoxin 2, putative
Oryza sativa 4344045   Os07g0638300
Oryza sativa 4335809   Os04g0416400
Oryza sativa 4329578   Os02g0537700
Oryza sativa 4344046   Os07g0638400
Plasmodium berghei PBANKA_1228000   1-cys peroxiredoxin, putative
Plasmodium berghei PBANKA_1430800   thioredoxin peroxidase 2, putative
Plasmodium berghei PBANKA_1302800   thioredoxin peroxidase 1
Plasmodium falciparum PF3D7_0802200   1-cys peroxiredoxin
Plasmodium falciparum PF3D7_1215000   thioredoxin peroxidase 2
Plasmodium falciparum PF3D7_1438900   thioredoxin peroxidase 1
Plasmodium knowlesi PKNH_1243400   thioredoxin peroxidase 1
Plasmodium knowlesi PKNH_0116700   1-cys peroxiredoxin
Plasmodium vivax PVX_118545   thioredoxin peroxidase 1, putative
Plasmodium vivax PVX_123435   thioredoxin peroxidase 2, putative
Plasmodium vivax PVX_093630   1-cys peroxiredoxin
Plasmodium yoelii PY00414   thioredoxin peroxidase 1
Plasmodium yoelii PY04285   1-cys peroxidoxin
Plasmodium yoelii PY02747   thioredoxin peroxidase 2
Saccharomyces cerevisiae YML028W   thioredoxin peroxidase TSA1
Saccharomyces cerevisiae YBL064C   Prx1p
Saccharomyces cerevisiae YDR453C   thioredoxin peroxidase TSA2
Schistosoma japonicum Sjp_0032370   Thioredoxin peroxidase, putative
Schistosoma japonicum Sjp_0053380   ko:K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC1.11.1.15], putative
Schistosoma japonicum Sjp_0113740   ko:K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC1.11.1.15], putative
Schistosoma japonicum Sjp_0095720   ko:K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC1.11.1.15], putative
Schistosoma japonicum Sjp_0047830   Thioredoxin peroxidase 2, putative
Schistosoma mansoni Smp_062900   peroxiredoxins prx-1 prx-2 prx-3
Schistosoma mansoni Smp_004470.3   thioredoxin peroxidase 3
Schistosoma mansoni Smp_158110.2   thioredoxin peroxidase
Schistosoma mansoni Smp_059480   thioredoxin peroxidase
Schmidtea mediterranea mk4.029516.05   Peroxiredoxin 1
Schmidtea mediterranea mk4.000185.13   Peroxiredoxin-6
Schmidtea mediterranea mk4.074720.01   Peroxiredoxin 1
Schmidtea mediterranea mk4.000577.03   Thioredoxin-dependent peroxide reductase, mitochondrial
Schmidtea mediterranea mk4.003817.00   Peroxiredoxin-4
Schmidtea mediterranea mk4.000973.03   Probable peroxiredoxin prdx-3
Trypanosoma brucei gambiense Tbg972.9.3050   tryparedoxin peroxidase, putative
Trypanosoma brucei gambiense Tbg972.8.1645   tryparedoxin peroxidase
Trypanosoma brucei gambiense Tbg972.9.3070   tryparedoxin peroxidase, putative
Trypanosoma brucei Tb927.8.1990   peroxidoxin
Trypanosoma brucei Tb927.9.5860   tryparedoxin peroxidase
Trypanosoma brucei Tb927.9.5770   tryparedoxin peroxidase
Trypanosoma congolense TcIL3000_9_1970   tryparedoxin peroxidase, putative
Trypanosoma congolense TcIL3000_8_2020   tryparedoxin peroxidase, putative
Trypanosoma congolense TcIL3000_9_1950   tryparedoxin peroxidase
Trypanosoma cruzi TcCLB.509445.10   tryparedoxin peroxidase, putative
Trypanosoma cruzi TcCLB.504839.44   tryparedoxin peroxidase
Trypanosoma cruzi TcCLB.504839.28   tryparedoxin peroxidase, putative
Trypanosoma cruzi TcCLB.509499.14   peroxidoxin
Trypanosoma cruzi TcCLB.507259.10   tryparedoxin peroxidase, putative
Trypanosoma cruzi TcCLB.505983.9   tryparedoxin peroxidase, putative
Trypanosoma cruzi TcCLB.487507.10   tryparedoxin peroxidase, putative
Toxoplasma gondii TGME49_217890   alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, putative
Toxoplasma gondii TGME49_309210   peroxiredoxin 6, putative
Treponema pallidum TP0509   alkyl hydroperoxide reductase (ahpC)
Theileria parva TP01_0177   2-Cys peroxiredoxin, putative
Theileria parva TP04_0036   thioredoxin peroxidase 1, putative
Trichomonas vaginalis TVAG_075420   alkyl hydroperoxide reductase, subunit C, putative
Trichomonas vaginalis TVAG_114310   peroxiredoxins, prx-1, prx-2, prx-3, putative
Trichomonas vaginalis TVAG_484570   alkyl hydroperoxide reductase, subunit C, putative
Trichomonas vaginalis TVAG_350540   alkyl hydroperoxide reductase, subunit C, putative
Trichomonas vaginalis TVAG_095250   alkyl hydroperoxide reductase, subunit C, putative
Trichomonas vaginalis TVAG_455310   peroxiredoxins, prx-1, prx-2, prx-3, putative
Trichomonas vaginalis TVAG_038090   alkyl hydroperoxide reductase, subunit C, putative
Trichomonas vaginalis TVAG_528900   peroxiredoxin, putative
Wolbachia endosymbiont of Brugia malayi Wbm0567   peroxiredoxin

Essentiality

TcCLB.487507.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.4250 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.4250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.4250 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.4250 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.1990 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.1990 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.1990 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.1990 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0605 Escherichia coli non-essential goodall
PBANKA_1302800 Plasmodium berghei Dispensable plasmo
PBANKA_1430800 Plasmodium berghei Dispensable plasmo
TGME49_217890 Toxoplasma gondii Probably non-essential sidik
TGME49_309210 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from over expression (ECO:0000120) Trypanosoma cruzi 551430  
Annotator: millerja@u.washington.edu. Comment: Note: this is more related to host macrophage oxidative stress and suggested these antioxidant systems are emerging virulence factors, as opposed to a more traditional drug target approach.. References: 17973627

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) Compounds References
Trypanosoma cruzi tryparedoxin peroxidase Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative Compounds References
Schistosoma mansoni thioredoxin peroxidase Compounds References
Trypanosoma cruzi tryparedoxin peroxidase, putative Compounds References
Mycobacterium leprae ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0142 0.2515 1
0.0121 0.354 1
0.039 1 1
0.0122 0.2507 1
0.0126 0.3338 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.487507.10 (Trypanosoma cruzi), tryparedoxin peroxidase, putative
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