Detailed view for LbrM.13.0190
Basic information
TDR Targets ID: 428762
Leishmania braziliensis, alpha tubulin
Source Database / ID:
Leishmania braziliensis, alpha tubulin
Source Database / ID:
pI: 4.6463 |
Length (AA): 451 |
MW (Da): 49683 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
Mouse over links to read term descriptions.
GO:0005874
microtubule GO:0005525 GTP binding
GO:0005200 structural constituent of cytoskeleton
GO:0003924 GTPase activity
GO:0007017 microtubule-based process
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 447 | 4i4t (A) | 1 | 450 | 82.00 | 0 | 1 | 2.04953 | -1.48 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126605)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT5G19770 | tubulin alpha-3 |
| Arabidopsis thaliana | AT1G64740 | tubulin alpha-1 chain |
| Arabidopsis thaliana | AT1G50010 | tubulin alpha-2 chain |
| Arabidopsis thaliana | AT4G14960 | tubulin alpha-6 chain |
| Arabidopsis thaliana | AT5G19780 | tubulin alpha-5 |
| Arabidopsis thaliana | AT1G04820 | tubulin alpha-4 chain |
| Babesia bovis | BBOV_IV004290 | tubulin alpha chain |
| Babesia bovis | BBOV_III002820 | tubulin alpha chain, putative |
| Brugia malayi | Bm1_25035 | Tubulin alpha-2 chain |
| Brugia malayi | Bm1_55400 | Tubulin alpha-2 chain |
| Brugia malayi | Bm1_20715 | tubulin alpha-2 chain |
| Brugia malayi | Bm1_38680 | tubulin alpha chain - mouse |
| Brugia malayi | Bm1_30260 | Tubulin alpha chain |
| Brugia malayi | Bm1_12120 | alpha-tubulin |
| Candida albicans | CaO19.7308 | cytoskeletal structural protein |
| Caenorhabditis elegans | CELE_C44B11.3 | Protein MEC-12 |
| Caenorhabditis elegans | CELE_ZK899.4 | Protein TBA-8 |
| Caenorhabditis elegans | CELE_F16D3.1 | Protein TBA-5 |
| Caenorhabditis elegans | CELE_C47B2.3 | Protein TBA-2 |
| Caenorhabditis elegans | CELE_F26E4.8 | Protein TBA-1, isoform A |
| Caenorhabditis elegans | CELE_F32H2.9 | Protein TBA-6 |
| Caenorhabditis elegans | CELE_F40F4.5 | Protein TBA-9 |
| Caenorhabditis elegans | CELE_T28D6.2 | Protein TBA-7 |
| Caenorhabditis elegans | CELE_F44F4.11 | Protein TBA-4 |
| Cryptosporidium hominis | Chro.40322 | alpha-tubulin |
| Cryptosporidium parvum | cgd4_2860 | alpha tubulin |
| Dictyostelium discoideum | DDB_G0281889 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0287689 | alpha tubulin |
| Drosophila melanogaster | Dmel_CG1913 | alpha-Tubulin at 84B |
| Drosophila melanogaster | Dmel_CG2512 | alpha-Tubulin at 84D |
| Drosophila melanogaster | Dmel_CG8308 | alpha-Tubulin at 67C |
| Drosophila melanogaster | Dmel_CG9476 | alpha-Tubulin at 85E |
| Echinococcus granulosus | EgrG_000359200 | peroxisome assembly protein 26 |
| Echinococcus granulosus | EgrG_000042500 | tubulin alpha 3 chain |
| Echinococcus granulosus | EgrG_000340000 | tubulin alpha chain |
| Echinococcus granulosus | EgrG_000042700 | tubulin alpha 1C chain |
| Echinococcus granulosus | EgrG_000413200 | tubulin alpha 1C chain |
| Echinococcus granulosus | EgrG_001070900 | tubulin alpha chain |
| Echinococcus granulosus | EgrG_000352800 | alpha tubulin |
| Echinococcus granulosus | EgrG_000042200 | Tubulin alpha 1 chain |
| Echinococcus granulosus | EgrG_000042600 | tubulin alpha 3 chain |
| Echinococcus granulosus | EgrG_000735000 | tubulin alpha chain |
| Echinococcus granulosus | EgrG_001124100 | tubulin alpha chain |
| Echinococcus granulosus | EgrG_000476400 | tubulin subunit TubB |
| Echinococcus granulosus | EgrG_000886400 | tubulin alpha chain |
| Echinococcus granulosus | EgrG_000040900 | Tubulin alpha 1 chain |
| Echinococcus granulosus | EgrG_000588000 | Tubulin alpha 1 chain |
| Entamoeba histolytica | EHI_010530 | tubulin alpha chain, putative |
| Entamoeba histolytica | EHI_005950 | tubulin alpha-1 chain |
| Echinococcus multilocularis | EmuJ_000042500 | tubulin alpha 3 chain |
| Echinococcus multilocularis | EmuJ_001070900 | tubulin alpha chain |
| Echinococcus multilocularis | EmuJ_000886400 | tubulin alpha chain |
| Echinococcus multilocularis | EmuJ_000588000 | Tubulin alpha 1 chain |
| Echinococcus multilocularis | EmuJ_000352800 | hypothetical protein |
| Echinococcus multilocularis | EmuJ_000340000 | tubulin alpha chain |
| Echinococcus multilocularis | EmuJ_000040900 | Tubulin alpha 1 chain |
| Echinococcus multilocularis | EmuJ_001124100 | tubulin alpha chain |
| Echinococcus multilocularis | EmuJ_000042600 | tubulin alpha 3 chain |
| Echinococcus multilocularis | EmuJ_000413200 | tubulin alpha 1C chain |
| Echinococcus multilocularis | EmuJ_000042200 | Tubulin alpha 1 chain |
| Echinococcus multilocularis | EmuJ_000476400 | tubulin subunit TubB |
| Echinococcus multilocularis | EmuJ_000735000 | tubulin alpha chain |
| Echinococcus multilocularis | EmuJ_000359200 | peroxisome assembly protein 26 |
| Echinococcus multilocularis | EmuJ_000042700 | tubulin alpha 1C chain |
| Giardia lamblia | GL50803_112079 | Alpha-tubulin |
| Giardia lamblia | GL50803_103676 | Alpha-tubulin |
| Homo sapiens | ENSG00000183785 | tubulin, alpha 8 |
| Homo sapiens | ENSG00000167552 | tubulin, alpha 1a |
| Homo sapiens | 101930571 | tubulin alpha-3E chain-like |
| Homo sapiens | ENSG00000167553 | tubulin, alpha 1c |
| Homo sapiens | ENSG00000152086 | tubulin, alpha 3e |
| Homo sapiens | ENSG00000075886 | tubulin, alpha 3d |
| Homo sapiens | ENSG00000123416 | tubulin, alpha 1b |
| Homo sapiens | ENSG00000178462 | tubulin, alpha-like 3 |
| Homo sapiens | ENSG00000127824 | tubulin, alpha 4a |
| Homo sapiens | ENSG00000198033 | tubulin, alpha 3c |
| Leishmania braziliensis | LbrM.13.0200 | alpha tubulin |
| Leishmania braziliensis | LbrM.13.0190 | alpha tubulin |
| Leishmania donovani | LdBPK_130330.1 | alpha tubulin |
| Leishmania infantum | LinJ.13.0330 | alpha tubulin |
| Leishmania infantum | LinJ.13.1460 | alpha tubulin |
| Leishmania major | LmjF.13.0290 | alpha tubulin |
| Leishmania major | LmjF.13.0300 | alpha tubulin |
| Leishmania major | LmjF.13.0380 | alpha tubulin |
| Leishmania major | LmjF.13.0390 | alpha tubulin |
| Leishmania major | LmjF.13.0340 | alpha tubulin |
| Leishmania major | LmjF.13.0310 | alpha tubulin |
| Leishmania major | LmjF.13.0320 | alpha tubulin |
| Leishmania major | LmjF.13.0330 | alpha tubulin |
| Leishmania major | LmjF.13.0350 | alpha tubulin |
| Leishmania major | LmjF.13.0280 | alpha tubulin |
| Leishmania major | LmjF.13.0370 | alpha tubulin |
| Leishmania major | LmjF.13.0360 | alpha tubulin |
| Leishmania mexicana | LmxM.13.0280 | alpha tubulin |
| Leishmania mexicana | LmxM.13.0390 | alpha tubulin |
| Loa Loa (eye worm) | LOAG_02850 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15945 | tubulin alpha 2 |
| Loa Loa (eye worm) | LOAG_16183 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_03501 | tubulin alpha-2 chain |
| Loa Loa (eye worm) | LOAG_02725 | tubulin alpha chain |
| Loa Loa (eye worm) | LOAG_15137 | tubulin alpha 2 |
| Loa Loa (eye worm) | LOAG_15565 | alpha-tubulin isotype 2 |
| Loa Loa (eye worm) | LOAG_13422 | tubulin alpha chain |
| Loa Loa (eye worm) | LOAG_16296 | tubulin alpha 2 |
| Loa Loa (eye worm) | LOAG_13355 | tubulin alpha-3 chain |
| Loa Loa (eye worm) | LOAG_10553 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_13743 | alpha-tubulin |
| Loa Loa (eye worm) | LOAG_12328 | alpha-tubulin |
| Mus musculus | ENSMUSG00000023004 | tubulin, alpha 1B |
| Mus musculus | ENSMUSG00000021216 | tubulin, alpha-like 3 |
| Mus musculus | ENSMUSG00000026202 | tubulin, alpha 4A |
| Mus musculus | ENSMUSG00000067338 | tubulin, alpha 3B |
| Mus musculus | ENSMUSG00000072235 | tubulin, alpha 1A |
| Mus musculus | 53857 | tubulin, alpha 8 |
| Mus musculus | ENSMUSG00000067702 | tubulin, alpha 3A |
| Mus musculus | ENSMUSG00000043091 | tubulin, alpha 1C |
| Neospora caninum | NCLIV_058890 | tubulin alpha chain |
| Oryza sativa | 4343694 | Os07g0574800 |
| Oryza sativa | 4332083 | Os03g0219300 |
| Oryza sativa | 4333966 | Os03g0726100 |
| Oryza sativa | 4350197 | Os11g0247300 |
| Plasmodium berghei | PBANKA_0522700 | alpha tubulin 2 |
| Plasmodium berghei | PBANKA_0417700 | alpha tubulin 1 |
| Plasmodium falciparum | PF3D7_0903700 | alpha tubulin 1 |
| Plasmodium falciparum | PF3D7_0422300 | alpha tubulin 2 |
| Plasmodium knowlesi | PKNH_0701400 | alpha tubulin, putative |
| Plasmodium knowlesi | PKNH_0514200 | alpha-tubulin II, putative |
| Plasmodium vivax | PVX_098630 | tubulin alpha chain, putative |
| Plasmodium vivax | PVX_090155 | tubulin alpha chain, putative |
| Plasmodium yoelii | PY01155 | tubulin alpha chain |
| Plasmodium yoelii | PY04063 | Tubulin/FtsZ family, putative |
| Saccharomyces cerevisiae | YML085C | alpha-tubulin TUB1 |
| Saccharomyces cerevisiae | YML124C | alpha-tubulin TUB3 |
| Schistosoma japonicum | Sjp_0301890 | Tubulin alpha chain, putative |
| Schistosoma japonicum | Sjp_0216350 | Tubulin alpha-1 chain, putative |
| Schistosoma japonicum | Sjp_0049920 | Tubulin alpha-2/alpha-4 chain, putative |
| Schistosoma japonicum | Sjp_0048410 | ko:K07374 tubulin alpha, putative |
| Schistosoma japonicum | Sjp_0004280 | ko:K07374 tubulin alpha, putative |
| Schistosoma japonicum | Sjp_0086780 | Tubulin alpha-1C chain, putative |
| Schistosoma mansoni | Smp_090120.1 | alpha tubulin |
| Schistosoma mansoni | Smp_090120.2 | alpha tubulin |
| Schistosoma mansoni | Smp_103140 | alpha tubulin |
| Schistosoma mansoni | Smp_016780 | tubulin subunit alpha |
| Schistosoma mansoni | Smp_103790 | tubulin subunit alpha |
| Schistosoma mansoni | Smp_027920 | tubulin subunit alpha |
| Schmidtea mediterranea | mk4.001038.00 | |
| Schmidtea mediterranea | mk4.015077.01 | |
| Schmidtea mediterranea | mk4.000118.09 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000742.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001866.01 | |
| Schmidtea mediterranea | mk4.001476.04 | |
| Schmidtea mediterranea | mk4.031023.00 | |
| Schmidtea mediterranea | mk4.000459.03 | |
| Schmidtea mediterranea | mk4.004574.02 | |
| Schmidtea mediterranea | mk4.003472.02 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.051830.00 | |
| Schmidtea mediterranea | mk4.001818.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000128.16 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000393.17 | |
| Schmidtea mediterranea | mk4.003554.05 | |
| Schmidtea mediterranea | mk4.015303.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.033428.00 | |
| Schmidtea mediterranea | mk4.008560.01 | |
| Schmidtea mediterranea | mk4.011918.02 | |
| Schmidtea mediterranea | mk4.000555.06 | |
| Schmidtea mediterranea | mk4.035478.00 | |
| Schmidtea mediterranea | mk4.005502.00 | |
| Schmidtea mediterranea | mk4.000046.21 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.006425.01 | |
| Schmidtea mediterranea | mk4.000382.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.032569.00 | |
| Schmidtea mediterranea | mk4.000027.17 | |
| Schmidtea mediterranea | mk4.016214.00 | |
| Schmidtea mediterranea | mk4.017860.00 | |
| Schmidtea mediterranea | mk4.000184.06 | |
| Schmidtea mediterranea | mk4.022859.00 | |
| Schmidtea mediterranea | mk4.002419.04 | |
| Schmidtea mediterranea | mk4.013691.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001011.04 | |
| Schmidtea mediterranea | mk4.025283.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.023172.00 | |
| Schmidtea mediterranea | mk4.010906.00 | |
| Schmidtea mediterranea | mk4.003693.03 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001331.03 | |
| Schmidtea mediterranea | mk4.000840.07 | |
| Schmidtea mediterranea | mk4.023807.01 | |
| Schmidtea mediterranea | mk4.000118.07 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000760.00 | |
| Schmidtea mediterranea | mk4.002876.05 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000400.01 | |
| Schmidtea mediterranea | mk4.000840.06 | |
| Schmidtea mediterranea | mk4.000397.06 | |
| Schmidtea mediterranea | mk4.008598.00 | |
| Schmidtea mediterranea | mk4.002422.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.013996.01 | |
| Schmidtea mediterranea | mk4.020028.00 | |
| Schmidtea mediterranea | mk4.022550.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.005316.03 | |
| Schmidtea mediterranea | mk4.001170.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003598.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.006425.00 | |
| Schmidtea mediterranea | mk4.003257.03 | |
| Schmidtea mediterranea | mk4.002655.05 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.018465.00 | |
| Schmidtea mediterranea | mk4.000097.14 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.004071.00 | |
| Schmidtea mediterranea | mk4.016278.00 | |
| Schmidtea mediterranea | mk4.006568.00 | Alpha tubulin |
| Schmidtea mediterranea | mk4.004071.03 | |
| Schmidtea mediterranea | mk4.000783.08 | Tubulin alpha-4A chain |
| Schmidtea mediterranea | mk4.003269.01 | |
| Schmidtea mediterranea | mk4.005160.00 | Tuba7l protein |
| Schmidtea mediterranea | mk4.003390.02 | |
| Schmidtea mediterranea | mk4.007562.00 | |
| Schmidtea mediterranea | mk4.006215.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000778.04 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000506.02 | |
| Schmidtea mediterranea | mk4.004616.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000695.03 | Tubulin alpha-4A chain |
| Schmidtea mediterranea | mk4.003996.01 | |
| Schmidtea mediterranea | mk4.029231.01 | |
| Schmidtea mediterranea | mk4.000840.00 | |
| Schmidtea mediterranea | mk4.014260.00 | Tubulin alpha-3 chain |
| Schmidtea mediterranea | mk4.005525.02 | |
| Schmidtea mediterranea | mk4.000268.07 | |
| Schmidtea mediterranea | mk4.006825.00 | |
| Schmidtea mediterranea | mk4.000955.02 | |
| Schmidtea mediterranea | mk4.005086.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001866.00 | |
| Schmidtea mediterranea | mk4.000613.03 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.005160.02 | Alpha tubulin |
| Schmidtea mediterranea | mk4.000030.19 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000003.23 | |
| Schmidtea mediterranea | mk4.003889.04 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.011565.02 | |
| Schmidtea mediterranea | mk4.007951.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003929.00 | |
| Schmidtea mediterranea | mk4.001921.01 | |
| Schmidtea mediterranea | mk4.033534.00 | |
| Schmidtea mediterranea | mk4.001999.06 | |
| Schmidtea mediterranea | mk4.000823.01 | |
| Schmidtea mediterranea | mk4.013763.00 | |
| Schmidtea mediterranea | mk4.022094.00 | |
| Schmidtea mediterranea | mk4.001476.03 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.002621.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003279.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.032380.00 | |
| Schmidtea mediterranea | mk4.003356.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.020610.02 | |
| Schmidtea mediterranea | mk4.014222.02 | |
| Schmidtea mediterranea | mk4.004929.01 | |
| Schmidtea mediterranea | mk4.001272.00 | |
| Schmidtea mediterranea | mk4.034558.01 | |
| Schmidtea mediterranea | mk4.000053.13 | |
| Schmidtea mediterranea | mk4.006868.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001169.02 | Putative tubulin alpha chain |
| Schmidtea mediterranea | mk4.000101.10 | |
| Schmidtea mediterranea | mk4.037833.00 | |
| Schmidtea mediterranea | mk4.000855.03 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003154.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.014871.00 | |
| Schmidtea mediterranea | mk4.001759.06 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.019056.00 | |
| Schmidtea mediterranea | mk4.000962.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.011078.00 | |
| Schmidtea mediterranea | mk4.001192.09 | |
| Schmidtea mediterranea | mk4.005473.04 | |
| Schmidtea mediterranea | mk4.000000.21 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000186.13 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003938.02 | |
| Schmidtea mediterranea | mk4.003482.02 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.028525.00 | |
| Schmidtea mediterranea | mk4.001762.01 | |
| Schmidtea mediterranea | mk4.003942.03 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.003482.03 | |
| Schmidtea mediterranea | mk4.013482.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.008179.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.007757.00 | |
| Schmidtea mediterranea | mk4.005830.01 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.001343.05 | |
| Schmidtea mediterranea | mk4.048802.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.002300.08 | |
| Schmidtea mediterranea | mk4.000470.10 | |
| Schmidtea mediterranea | mk4.003942.04 | |
| Schmidtea mediterranea | mk4.017512.01 | |
| Schmidtea mediterranea | mk4.003937.04 | |
| Schmidtea mediterranea | mk4.036982.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.000467.03 | |
| Schmidtea mediterranea | mk4.004965.02 | |
| Schmidtea mediterranea | mk4.000695.04 | Tubulin alpha-4A chain |
| Schmidtea mediterranea | mk4.007932.00 | |
| Schmidtea mediterranea | mk4.003853.00 | |
| Schmidtea mediterranea | mk4.013009.01 | |
| Schmidtea mediterranea | mk4.016475.00 | |
| Schmidtea mediterranea | mk4.018496.00 | |
| Schmidtea mediterranea | mk4.005380.00 | |
| Schmidtea mediterranea | mk4.011462.00 | |
| Schmidtea mediterranea | mk4.024688.00 | |
| Schmidtea mediterranea | mk4.003269.02 | |
| Schmidtea mediterranea | mk4.000470.09 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.004240.01 | |
| Schmidtea mediterranea | mk4.006884.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.022625.00 | Tubulin alpha chain-like 3 |
| Schmidtea mediterranea | mk4.015159.00 | |
| Schmidtea mediterranea | mk4.000840.05 | |
| Schmidtea mediterranea | mk4.004131.00 | |
| Schmidtea mediterranea | mk4.017635.00 | |
| Schmidtea mediterranea | mk4.015506.00 | |
| Schmidtea mediterranea | mk4.003162.01 | Tubulin alpha chain-like 3 |
| Trypanosoma brucei gambiense | Tbg972.1.1360 | alpha tubulin |
| Trypanosoma brucei | Tb927.1.2340 | alpha tubulin |
| Trypanosoma brucei | Tb927.1.2360 | alpha tubulin |
| Trypanosoma brucei | Tb927.1.2400 | alpha tubulin |
| Trypanosoma brucei | Tb927.1.2380 | alpha tubulin |
| Trypanosoma congolense | TcIL3000_0_31230 | alpha tubulin |
| Trypanosoma cruzi | TcCLB.411235.9 | alpha tubulin, putative |
| Toxoplasma gondii | TGME49_316400 | alpha tubulin TUBA1 |
| Toxoplasma gondii | TGME49_231770 | alpha-tubulin I, putative |
| Theileria parva | TP01_0324 | tubulin alpha chain, putative |
| Theileria parva | TP04_0093 | Tubulin alpha chain, putative |
| Trichomonas vaginalis | TVAG_448410 | tubulin alpha-1 chain, putative |
| Trichomonas vaginalis | TVAG_448390 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_523980 | tubulin epsilon chain, putative |
| Trichomonas vaginalis | TVAG_519620 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_359090 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_312330 | tubulin alpha-1 chain, putative |
| Trichomonas vaginalis | TVAG_206890 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_345420 | tubulin alpha-1 chain, putative |
| Trichomonas vaginalis | TVAG_467840 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_196270 | tubulin beta chain, putative |
| Trichomonas vaginalis | TVAG_360870 | tubulin epsilon chain, putative |
Essentiality
LbrM.13.0190 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_C44B11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C44B11.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C44B11.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F26E4.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F26E4.8 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F26E4.8 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F26E4.8 | Caenorhabditis elegans | sterile | wormbase |
| CELE_C47B2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C47B2.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C47B2.3 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_C47B2.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C47B2.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F44F4.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F44F4.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F44F4.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F44F4.11 | Caenorhabditis elegans | sterile | wormbase |
| YML085C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_0417700 | Plasmodium berghei | Dispensable | plasmo |
| PBANKA_0522700 | Plasmodium berghei | Essential | plasmo |
| TGME49_231770 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_316400 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_231770 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_316400 | Toxoplasma gondii | Probably essential | sidik |
-
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Sus scrofa | Tubulin | 445 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Bos taurus | Tubulin beta chain | 445 aa | 40.3% | 434 aa | Compounds | References |
| Trypanosoma brucei | tubulin gamma chain | 447 aa | 32.4% | 451 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania donovani | Beta tubulin | 43 aa | 43.6% | 39 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Trypanosoma brucei | beta tubulin | 442 aa | 40.1% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Bos taurus | Tubulin | 85 aa | 69.8% | 86 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | gamma-tubulin | 447 aa | 33.0% | 451 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
| Plasmodium falciparum | tubulin beta chain | 445 aa | 40.5% | 434 aa | Compounds | References |
| Leishmania major | beta tubulin | 443 aa | 40.3% | 434 aa | Compounds | References |
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
No user comments are available for this gene.
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