Detailed view for LbrM.34.3980

Basic information

TDR Targets ID: 428975
Leishmania braziliensis, protein kinase, putative,MAP kinase kinase-like protein
Source Database / ID: 

pI: 6.0533 | Length (AA): 1416 | MW (Da): 154533 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00632   HECT-domain (ubiquitin-transferase)
PF07719   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
119 247 3sz7 (A) 107 235 27.00 0 1 0.534802 -1
123 245 3upv (A) 259 381 24.00 0 1 0.469264 -1.17
130 204 4cgu (A) 8 88 36.00 0.044 0.82 0.320566 -0.31
351 601 5cwi (A) 14 234 24.00 0.37 1 0.35696 -0.16
539 859 4o1p (A) 186 501 26.00 0.062 0.72 0.128295 1.55
550 760 4tql (A) 21 231 14.00 0.00016 0.11 0.195711 -0.32
597 926 1k9a (A) 93 379 28.00 0.000000028 0.86 0.144651 1.39
599 1048 5uvc (A) 39 535 20.00 0 1 0.340197 0.73
676 987 3gop (A) 652 940 24.00 0 1 0.205039 0.69
709 1268 5ce3 (B) 118 720 15.00 0 1 0.34388 0.87
719 993 2y7j (A) 21 291 26.00 0 1 0.461909 -0.34
722 997 2rku (A) 53 309 26.00 0 1 0.447615 -0.29
735 926 4uya (A) 137 337 39.00 0.000000085 0.99 0.200193 0.69
979 1408 5tj7 (A) 358 863 21.00 0 1 0.396372 0.51
1011 1407 2oni (A) 576 946 22.00 0 1 0.421067 0.23
1320 1406 3pt3 (A) 2702 2791 22.00 0 0.58 0.244841 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_163570)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0276527   CAMKL family protein kinase
Leishmania braziliensis LbrM.34.3980   protein kinase, putative,MAP kinase kinase-like protein
Leishmania donovani LdBPK_354050.1   protein kinase, putative
Leishmania infantum LinJ.35.4050   protein kinase, putative,MAP kinase kinase-like protein
Leishmania major LmjF.35.4000   protein kinase, putative,MAP kinase kinase-like protein
Leishmania mexicana LmxM.34.4000   protein kinase, putative,MAP kinase kinase-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 24.8% 302 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 28.9% 166 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 21.3% 267 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.7% 304 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.6% 287 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.5% 310 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.1% 278 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 24.6% 305 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 23.9% 297 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LbrM.34.3980 (Leishmania braziliensis), protein kinase, putative,MAP kinase kinase-like protein
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