pI: 9.7341 |
Length (AA): 705 |
MW (Da): 80167 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 127 | 2fe0 (A) | 3 | 129 | 34.00 | 0 | 0.95 | 0.51835 | -0.26 |
14 | 122 | 1r75 (A) | 13 | 130 | 29.00 | 0 | 0.74 | 0.48791 | -0.67 |
130 | 504 | 1qxp (B) | 2 | 362 | 34.00 | 0 | 1 | 0.642215 | 1.03 |
131 | 657 | 1kfu (L) | 7 | 528 | 22.00 | 0 | 1 | 0.805818 | 0.88 |
144 | 492 | 1mdw (A) | 22 | 341 | 29.00 | 0 | 1 | 0.701335 | 0.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129863)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_34510 | calpain D |
Caenorhabditis elegans | CELE_T11A5.6 | Protein T11A5.6, isoform C |
Caenorhabditis elegans | CELE_W05G11.4 | Protein W05G11.4 |
Drosophila melanogaster | Dmel_CG1391 | small optic lobes |
Entamoeba histolytica | EHI_045290 | calpain family cysteine protease, putative |
Homo sapiens | ENSG00000103326 | calpain 15 |
Leishmania braziliensis | LbrM.25.1350 | calpain family cysteine protease-like protein |
Leishmania donovani | LdBPK_251540.1 | calpain family cysteine protease-like protein |
Leishmania infantum | LinJ.25.1540 | calpain family cysteine protease-like protein |
Leishmania major | LmjF.25.1480 | calpain family cysteine protease-like protein |
Leishmania mexicana | LmxM.25.1480 | calpain family cysteine protease-like protein |
Loa Loa (eye worm) | LOAG_01157 | calpain D |
Mus musculus | ENSMUSG00000037326 | calpain 15 |
Schmidtea mediterranea | mk4.005279.01 | |
Schmidtea mediterranea | mk4.005279.00 | |
Schmidtea mediterranea | mk4.027150.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | calpain family cysteine protease-like protein | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Leishmania major | small myristoylated protein-3, putative | 115 aa | 34.6% | 104 aa | Compounds | References |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 687 aa | 34.2% | 681 aa | Compounds | References |
Leishmania major | small myristoylated protein-1 | 131 aa | 34.1% | 129 aa | Compounds | References |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 414 aa | 25.5% | 427 aa | Compounds | References |