pI: 7.3498 |
Length (AA): 576 |
MW (Da): 64335 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_165000)
Species | Accession | Gene Product |
---|---|---|
Entamoeba histolytica | EHI_161960 | protein kinase, putative |
Leishmania braziliensis | LbrM.34.1770 | protein kinase-like protein |
Leishmania donovani | LdBPK_351850.1 | protein kinase-like protein |
Leishmania infantum | LinJ.35.1850 | protein kinase-like protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 29.6% | 324 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 32.9% | 173 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 27.3% | 322 aa | Compounds | References |
Bos taurus | Casein kinase I isoform alpha | 325 aa | 23.9% | 264 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-A | 361 aa | 25.3% | 316 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 26.8% | 321 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 8 | 411 aa | 28.4% | 349 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-B | 368 aa | 25.9% | 316 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 28.2% | 319 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 27.1% | 321 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 28.3% | 321 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 25.8% | 329 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 29.2% | 277 aa | Compounds | References |