Detailed view for LbrM.25.1100

Basic information

TDR Targets ID: 430321
Leishmania braziliensis, aldehyde dehydrogenase, mitochondrial precursor

Source Database / ID: 

pI: 7.7087 | Length (AA): 499 | MW (Da): 53854 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF00171   Aldehyde dehydrogenase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 493 1o9j (A) 8 496 48.00 0 1 1.57317 -0.62
7 493 4qf6 (A) 4 494 53.00 0 1 1.67645 -0.89
11 492 2o2p (A) 413 902 43.00 0.00000000032 1 1.51913 -0.78
19 492 4cbb (A) 6 483 42.00 0 1 1.5434 -0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126638)

Species Accession Gene Product
Arabidopsis thaliana AT3G48000   aldehyde dehydrogenase 2B4
Arabidopsis thaliana AT2G24270   NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Arabidopsis thaliana AT1G23800   aldehyde dehydrogenase 2B7
Arabidopsis thaliana AT3G24503   aldehyde dehydrogenase 2C4
Candida albicans CaO19.5806   aldehyde dehydrogenase
Candida albicans CaO19.13683   Mitochondrial aldehyde dehydrogenase
Candida albicans CaO19.13228   aldehyde dehydrogenase
Candida albicans CaO19.6306   Mitochondrial aldehyde dehydrogenase
Caenorhabditis elegans CELE_F54D8.3   Protein ALH-1, isoform B
Caenorhabditis elegans CELE_K04F1.15   Protein ALH-2
Dictyostelium discoideum DDB_G0290537   aldehyde dehydrogenase
Dictyostelium discoideum DDB_G0290479   aldehyde dehydrogenase
Dictyostelium discoideum DDB_G0290535   aldehyde dehydrogenase
Dictyostelium discoideum DDB_G0288521   aldehyde dehydrogenase
Dictyostelium discoideum DDB_G0270028   aldehyde dehydrogenase
Drosophila melanogaster Dmel_CG31075   CG31075 gene product from transcript CG31075-RA
Drosophila melanogaster Dmel_CG3752   Aldehyde dehydrogenase
Escherichia coli b3588   aldehyde dehydrogenase B
Escherichia coli b1300   gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
Echinococcus granulosus EgrG_000389100   aldehyde dehydrogenase mitochondrial
Echinococcus multilocularis EmuJ_000389100   aldehyde dehydrogenase, mitochondrial
Homo sapiens ENSG00000111275   aldehyde dehydrogenase 2 family (mitochondrial)
Homo sapiens ENSG00000137124   aldehyde dehydrogenase 1 family, member B1
Homo sapiens ENSG00000184254   aldehyde dehydrogenase 1 family, member A3
Homo sapiens ENSG00000165092   aldehyde dehydrogenase 1 family, member A1
Homo sapiens ENSG00000128918   aldehyde dehydrogenase 1 family, member A2
Leishmania braziliensis LbrM.25.1100   aldehyde dehydrogenase, mitochondrial precursor
Leishmania donovani LdBPK_251160.1   aldehyde dehydrogenase, mitochondrial precursor
Leishmania infantum LinJ.25.1160   aldehyde dehydrogenase, mitochondrial precursor
Leishmania major LmjF.25.1120   aldehyde dehydrogenase, mitochondrial precursor
Leishmania mexicana LmxM.25.1120   aldehyde dehydrogenase, mitochondrial precursor
Mus musculus ENSMUSG00000015134   aldehyde dehydrogenase family 1, subfamily A3
Mus musculus ENSMUSG00000053279   aldehyde dehydrogenase family 1, subfamily A1
Mus musculus ENSMUSG00000013584   aldehyde dehydrogenase family 1, subfamily A2
Mus musculus 11669   aldehyde dehydrogenase 2, mitochondrial
Mus musculus ENSMUSG00000024747   aldehyde dehydrogenase family 1, subfamily A7
Mus musculus ENSMUSG00000035561   aldehyde dehydrogenase 1 family, member B1
Mycobacterium tuberculosis Rv0458   Probable aldehyde dehydrogenase
Mycobacterium ulcerans MUL_2877   aldehyde dehydrogenase
Mycobacterium ulcerans MUL_0494   aldehyde dehydrogenase
Mycobacterium ulcerans MUL_1416   aldehyde dehydrogenase
Neospora caninum NCLIV_005550   hypothetical protein
Oryza sativa 4326375   Os01g0591000
Oryza sativa 4340725   Os06g0270900
Oryza sativa 4330612   Os02g0730000
Oryza sativa 4345685   Os08g0440800
Oryza sativa 4326376   Os01g0591300
Saccharomyces cerevisiae YMR169C   aldehyde dehydrogenase (NAD(+)) ALD3
Saccharomyces cerevisiae YMR170C   aldehyde dehydrogenase (NAD(+)) ALD2
Saccharomyces cerevisiae YER073W   aldehyde dehydrogenase (NAD(P)(+)) ALD5
Saccharomyces cerevisiae YOR374W   aldehyde dehydrogenase (NADP(+)) ALD4
Schistosoma japonicum Sjp_0208240   ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative
Schistosoma japonicum Sjp_0133930   Aldehyde dehydrogenase, mitochondrial precursor, putative
Schistosoma japonicum Sjp_0011180   Retinal dehydrogenase 1, putative
Schistosoma japonicum Sjp_0103820   Aldehyde dehydrogenase X, mitochondrial precursor, putative
Schistosoma mansoni Smp_022960   aldehyde dehydrogenase
Schistosoma mansoni Smp_050390   aldehyde dehydrogenase
Schmidtea mediterranea mk4.000152.00  
Schmidtea mediterranea mk4.040550.01  
Schmidtea mediterranea mk4.004393.00   Aldehyde dehydrogenase,putative
Toxoplasma gondii TGME49_222160   aldehyde dehydrogenase

Essentiality

LbrM.25.1100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu462 Mycobacterium tuberculosis non-essential nmpdr
b1300 Escherichia coli non-essential goodall
b3588 Escherichia coli non-essential goodall
TGME49_222160 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Aldehyde dehydrogenase 1A1 Compounds References
Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) Compounds References
Rattus norvegicus Aldehyde dehydrogenase, cytosolic 1 Compounds References
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Compounds References
Rattus norvegicus Aldehyde dehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LbrM.25.1100 (Leishmania braziliensis), aldehyde dehydrogenase, mitochondrial precursor
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