Detailed view for LbrM.10.0620

Basic information

TDR Targets ID: 431501
Leishmania braziliensis, mitogen-activated protein kinase 3, putative,map kinase 3, putative
Source Database / ID: 

pI: 6.2272 | Length (AA): 388 | MW (Da): 43714 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0004707   MAP kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Leishmaniasis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 363 4o2z (A) 17 377 95.00 0 1 2.09721 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128610)

Species Accession Gene Product
Brugia malayi Bm1_31785   P38 map kinase family protein 2
Candida albicans CaO19.895   MAP kinase involved in osmoregulation
Candida albicans CaO19.8514   MAP kinase involved in osmoregulation
Caenorhabditis elegans CELE_B0218.3   Protein PMK-1
Drosophila melanogaster Dmel_CG5475   p38a MAP kinase
Drosophila melanogaster Dmel_CG7393   p38b MAP kinase
Echinococcus granulosus EgrG_000145100   mitogen activated protein kinase 11
Echinococcus granulosus EgrG_000144900   mitogen activated protein kinase 14
Echinococcus multilocularis EmuJ_000145100   mitogen activated protein kinase 11
Echinococcus multilocularis EmuJ_000139200   mitogen activated protein kinase 11
Echinococcus multilocularis EmuJ_000139400   mitogen activated protein kinase 14
Echinococcus multilocularis EmuJ_000144900   mitogen activated protein kinase 14
Homo sapiens 5603   mitogen-activated protein kinase 13
Homo sapiens ENSG00000185386   mitogen-activated protein kinase 11
Homo sapiens ENSG00000112062   mitogen-activated protein kinase 14
Leishmania braziliensis LbrM.10.0620   mitogen-activated protein kinase 3, putative,map kinase 3, putative
Leishmania donovani LdBPK_100540.1   mitogen-activated protein kinase 3, putative
Leishmania infantum LinJ.10.0540   mitogen-activated protein kinase 3, putative,map kinase 3, putative
Leishmania major LmjF.10.0490   mitogen-activated protein kinase 3, putative,map kinase 3, putative
Leishmania mexicana LmxM.10.0490   mitogen-activated protein kinase 3, putative,map kinase 3, putative
Loa Loa (eye worm) LOAG_06056   CMGC/MAPK/P38 protein kinase
Mus musculus ENSMUSG00000053436   mitogen-activated protein kinase 14
Mus musculus ENSMUSG00000053137   mitogen-activated protein kinase 11
Mus musculus ENSMUSG00000004864   mitogen-activated protein kinase 13
Saccharomyces cerevisiae YLR113W   mitogen-activated protein kinase HOG1
Schistosoma japonicum Sjp_0211950   ko:K04441 p38 MAP kinase, putative
Schmidtea mediterranea mk4.016082.00   Putative mitogen-activated protein kinase 14C
Trypanosoma brucei gambiense Tbg972.8.3240   mitogen-activated protein kinase 3, putative
Trypanosoma brucei Tb927.8.3550   mitogen-activated protein kinase 3, putative
Trypanosoma congolense TcIL3000_8_3490   mitogen-activated protein kinase 3, putative
Trypanosoma cruzi TcCLB.509553.60   mitogen-activated protein kinase 3, putative
Trypanosoma cruzi TcCLB.509475.10   mitogen-activated protein kinase 3, putative

Essentiality

LbrM.10.0620 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.3550 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.3550 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.3550 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.3550 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus mitogen-activated protein kinase 11 Compounds References
Rattus norvegicus MAP kinase p38 alpha Compounds References
Mus musculus mitogen-activated protein kinase 14 Compounds References
Homo sapiens mitogen-activated protein kinase 11 Compounds References
Homo sapiens mitogen-activated protein kinase 13 Compounds References
Homo sapiens mitogen-activated protein kinase 14 Compounds References
Mus musculus mitogen-activated protein kinase 13 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 34.0% 309 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 24.6% 179 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.3% 311 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 34.4% 305 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 40.3% 352 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 37.2% 296 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 37.3% 169 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 34.1% 302 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LbrM.10.0620 (Leishmania braziliensis), mitogen-activated protein kinase 3, putative,map kinase 3, putative
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