Detailed view for LbrM.30.0920

Basic information

TDR Targets ID: 432166
Leishmania braziliensis, rac serine-threonine kinase, putative,protein kinase, putative
Source Database / ID: 

pI: 6.4104 | Length (AA): 510 | MW (Da): 57372 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 89 2y7b (A) 986 1103 18.00 0 0.94 0.21131 -1.69
1 97 4nsw (A) 268 364 23.00 0.012 0.74 0.581096 -1.48
2 385 4ejn (A) 9 434 35.00 0 1 1.09284 -0.11
13 416 3ndm (C) 6 402 26.00 0 1 0.887957 0.78
47 473 3uzs (A) 132 577 24.00 0 1 0.926055 1.08
97 388 4nw6 (A) 59 359 44.00 0 1 1.13045 -0.79
100 378 2z7q (A) 56 340 46.00 0 1 0.928859 -0.1
102 361 3bhh (A) 9 274 28.00 0 1 0.843604 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128147)

Species Accession Gene Product
Brugia malayi Bm1_24015   ribosomal protein S6 kinase alpha 3
Candida albicans CaO19.13654   Serine/threonine protein kinase
Candida albicans CaO19.6275   Serine/threonine protein kinase
Caenorhabditis elegans CELE_T01H8.1   Protein RSKN-1, isoform D
Dictyostelium discoideum DDB_G0277449   SGK family protein kinase
Drosophila melanogaster Dmel_CG17596   Ribosomal protein S6 kinase II
Echinococcus granulosus EgrG_000641400   ribosomal protein S6 kinase alpha 3
Echinococcus multilocularis EmuJ_000641400   ribosomal protein S6 kinase alpha 3
Giardia lamblia GL50803_11364   Kinase, AGC AKT
Homo sapiens ENSG00000072133   ribosomal protein S6 kinase, 90kDa, polypeptide 6
Homo sapiens ENSG00000117676   ribosomal protein S6 kinase, 90kDa, polypeptide 1
Homo sapiens ENSG00000071242   ribosomal protein S6 kinase, 90kDa, polypeptide 2
Homo sapiens ENSG00000177189   ribosomal protein S6 kinase, 90kDa, polypeptide 3
Leishmania braziliensis LbrM.30.0920   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania donovani LdBPK_300850.1   rac serine-threonine kinase, putative
Leishmania infantum LinJ.30.0850   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania major LmjF.30.0800   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania mexicana LmxM.29.0800   rac serine-threonine kinase, putative,protein kinase, putative
Loa Loa (eye worm) LOAG_01357   AGC/RSK/RSK protein kinase
Mus musculus ENSMUSG00000023809   ribosomal protein S6 kinase, polypeptide 2
Mus musculus ENSMUSG00000025665   ribosomal protein S6 kinase polypeptide 6
Mus musculus ENSMUSG00000031309   ribosomal protein S6 kinase polypeptide 3
Mus musculus ENSMUSG00000003644   ribosomal protein S6 kinase polypeptide 1
Saccharomyces cerevisiae YBR028C   Ypk3p
Schistosoma japonicum Sjp_0216210   Ribosomal protein S6 kinase alpha-2, putative
Schistosoma japonicum Sjp_0106250   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0129060   IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing
Schistosoma mansoni Smp_017900   serine/threonine protein kinase
Schmidtea mediterranea mk4.003305.00  
Schmidtea mediterranea mk4.001465.05  
Schmidtea mediterranea mk4.006921.00   Putative ribosomal protein S6 kinase alpha-1
Schmidtea mediterranea mk4.000379.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 Compounds References
Mus musculus ribosomal protein S6 kinase polypeptide 3 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 2 Compounds References
Mus musculus ribosomal protein S6 kinase, polypeptide 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.4% 291 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.4% 295 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 28.3% 198 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.0% 292 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.7% 296 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 27.3% 297 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.4% 292 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.0% 292 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LbrM.30.0920 (Leishmania braziliensis), rac serine-threonine kinase, putative,protein kinase, putative
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