Detailed view for TcCLB.416143.10

Basic information

TDR Targets ID: 43267
Trypanosoma cruzi, Lys-63-specific deubiquitinase BRCC36, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6247 | Length (AA): 273 | MW (Da): 30159 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01398   JAB1/Mov34/MPN/PAD-1 ubiquitin protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 269 5cw4 (A) 4 245 31.00 0 1 1.27187 -0.03
19 181 5cw6 (A) 5 164 42.00 0 0.99 1.05887 -0.68
21 269 5cw4 (A) 5 245 32.00 0 1 1.29009 -0.26
73 179 5cw6 (A) 45 164 50.00 0 0.99 0.982941 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132023)

Species Accession Gene Product
Arabidopsis thaliana AT3G06820   BRCA1/BRCA2-containing complex subunit 36B
Arabidopsis thaliana AT1G80210   BRCA1/BRCA2-containing complex subunit 36-like A
Echinococcus granulosus EgrG_000796000   lys 63 specific deubiquitinase BRCC36
Echinococcus multilocularis EmuJ_000796000   lys 63 specific deubiquitinase BRCC36
Homo sapiens ENSG00000185515   BRCA1/BRCA2-containing complex, subunit 3
Leishmania braziliensis LbrM.26.2360   metallopeptidase, putative,metallo-peptidase, Clan MP, Family M67
Leishmania donovani LdBPK_262450.1   Lys-63-specific deubiquitinase BRCC36, putative
Leishmania major LmjF.26.2430   metallopeptidase, putative,metallo-peptidase, Clan MP, Family M67
Leishmania mexicana LmxM.26.2430   metallopeptidase, putative,metallo-peptidase, Clan MP, Family M67
Mus musculus 368203   predicted gene 5136
Mus musculus ENSMUSG00000031201   BRCA1/BRCA2-containing complex, subunit 3
Oryza sativa 4339481   Os05g0542600
Trypanosoma brucei gambiense Tbg972.9.380   Mov34/MPN/PAD-1 metallopeptidase, putative,metallo-peptidase, Clan MP, Family M67
Trypanosoma brucei Tb927.9.1680   Lys-63-specific deubiquitinase BRCC36, putative
Trypanosoma congolense TcIL3000_9_270   Lys-63-specific deubiquitinase BRCC36, putative
Trypanosoma cruzi TcCLB.416143.10   Lys-63-specific deubiquitinase BRCC36, putative
Trypanosoma cruzi TcCLB.510349.90   Lys-63-specific deubiquitinase BRCC36, putative
Trypanosoma cruzi TcCLB.506715.20   Lys-63-specific deubiquitinase BRCC36, putative
Trypanosoma cruzi TcCLB.506463.10   Lys-63-specific deubiquitinase BRCC36, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.416143.10 (Trypanosoma cruzi), Lys-63-specific deubiquitinase BRCC36, putative
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