Detailed view for LinJ.28.1800

Basic information

TDR Targets ID: 436031
Leishmania infantum, zinc finger protein kinase-like
Source Database / ID: 

pI: 7.6877 | Length (AA): 1323 | MW (Da): 142378 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00787   PX domain
PF13924   Lipocalin-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035091   phosphoinositide binding  
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
113 212 1xte (A) 4 96 27.00 0 0.92 0.206686 -0.22
118 293 5gw1 (G) 109 276 21.00 0 1 0.200131 0.5
118 216 4az9 (A) 2 90 35.00 0.00002 1 0.38313 -1.06
129 212 2dyb (A) 37 117 37.00 0.1 0.68 0.258892 0.16
526 992 4yhj (A) 72 511 27.00 0 1 0.496086 0.24
604 908 5k5x (A) 557 964 23.00 0 1 0.447837 -0.15
604 852 5k5x (A) 557 909 30.00 0.000000029 0.96 0.367609 0.5
630 959 4hpu (E) 31 334 33.00 0 1 0.605733 -0.64
634 987 4otd (A) 613 944 37.00 0 1 0.660874 -0.51
637 1138 5iso (A) 11 547 26.00 0 1 0.494741 0.87
760 831 4jrn (A) 403 474 44.00 0.00024 0.17 0.320822 0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_148825)

Species Accession Gene Product
Leishmania braziliensis LbrM.28.1850   zinc finger protein kinase-like
Leishmania donovani LdBPK_281800.1   differentiation inhibitory kinase, putative
Leishmania infantum LinJ.28.1800   zinc finger protein kinase-like
Leishmania major LmjF.28.1670   zinc finger protein kinase-like
Leishmania mexicana LmxM.28.1670   zinc finger protein kinase-like
Trypanosoma brucei gambiense Tbg972.11.10370   protein kinase,zinc finger protein kinase, putative
Trypanosoma brucei Tb927.11.9270   differentiation inhibitory kinase
Trypanosoma congolense TcIL3000.11.9670   differentiation inhibitory kinase, putative
Trypanosoma congolense TcIL3000_0_28060   differentiation inhibitory kinase
Trypanosoma cruzi TcCLB.510901.200   zinc finger protein kinase, putative

Essentiality

LinJ.28.1800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.1030 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.1030 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.9% 301 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 26.1% 314 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.9% 297 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 31.1% 315 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.4% 315 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.1% 315 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 26.1% 303 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LinJ.28.1800 (Leishmania infantum), zinc finger protein kinase-like
Title for this comment
Comment