Detailed view for LinJ.25.2110

Basic information

TDR Targets ID: 437682
Leishmania infantum, hypothetical protein, conserved

Source Database / ID: 

pI: 6.0763 | Length (AA): 366 | MW (Da): 39505 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF03031   NLI interacting factor-like phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
39 136 2mqa (A) 19 114 12.00 0 0.01 0.39896 -0.63
160 362 4qqf (A) 169 357 31.00 0 1 0.874445 -0.34
168 349 2ght (A) 77 256 46.00 0 1 1.13407 -1.11
170 352 2q5e (A) 90 270 47.00 0 1 1.1437 -0.96
173 259 4xpz (A) 154 258 32.00 0.035 0.91 0.431405 0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127075)

Species Accession Gene Product
Arabidopsis thaliana AT5G45700   haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT1G29780   Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT1G29770   haloacid dehalogenase-like hydrolase
Babesia bovis BBOV_III004040   Dullard-like phosphatase domain containing protein
Brugia malayi Bm1_47855   Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1
Candida albicans CaO19.12861   Plasma membrane Sodium Response 1
Candida albicans CaO19.5406   Plasma membrane Sodium Response 1
Caenorhabditis elegans CELE_B0379.4   Protein SCPL-1, isoform C
Cryptosporidium hominis Chro.20406   hypothetical protein
Cryptosporidium parvum cgd2_3810   hypothetical protein
Dictyostelium discoideum DDB_G0294376   hypothetical protein
Drosophila melanogaster Dmel_CG8584   CG8584 gene product from transcript CG8584-RA
Drosophila melanogaster Dmel_CG5830   CG5830 gene product from transcript CG5830-RA
Echinococcus granulosus EgrG_001015050   CTD small phosphatase protein like
Echinococcus granulosus EgrG_001046000   Carboxy terminal domain RNA polymerase II
Entamoeba histolytica EHI_127190   NLI interacting factor-like phosphatase domain-containing protein
Echinococcus multilocularis EmuJ_001015050  
Echinococcus multilocularis EmuJ_001046000   Carboxy terminal domain RNA polymerase II
Giardia lamblia GL50803_4063   Nuclear LIM interactor-interacting factor 1
Homo sapiens ENSG00000144579   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Homo sapiens ENSG00000144677   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
Homo sapiens ENSG00000175215   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Leishmania braziliensis LbrM.25.1590   hypothetical protein, conserved
Leishmania donovani LdBPK_252110.1   dullard-like phosphatase domain containing protein, putative
Leishmania infantum LinJ.25.2110   hypothetical protein, conserved
Leishmania major LmjF.25.2030   hypothetical protein, conserved
Leishmania mexicana LmxM.25.2030   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_16239   hypothetical protein
Loa Loa (eye worm) LOAG_08577   hypothetical protein
Mus musculus ENSMUSG00000026176   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Mus musculus ENSMUSG00000047409   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
Mus musculus ENSMUSG00000078429   CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Neospora caninum NCLIV_054710   hypothetical protein
Neospora caninum NCLIV_018590   hypothetical protein
Oryza sativa 4326854   Os01g0665300
Oryza sativa 4338072   Os05g0205100
Plasmodium berghei PBANKA_1403300   NLI interacting factor-like phosphatase
Plasmodium berghei PBANKA_1115500   NLI interacting factor-like phosphatase
Plasmodium falciparum PF3D7_0515900   NLI interacting factor-like phosphatase, putative
Plasmodium knowlesi PKNH_1405000   NLI interacting factor-like phosphatase, putative
Plasmodium knowlesi PKNH_1017300   NLI interacting factor-like phosphatase, putative
Plasmodium vivax PVX_080450   NLI interacting factor-like phosphatase, putative
Plasmodium vivax PVX_122077   NLI interacting factor-like phosphatase, putative
Plasmodium yoelii PY00230   NLI interacting factor, putative
Plasmodium yoelii PY00226   NLI interacting factor, putative
Saccharomyces cerevisiae YLR019W   Psr2p
Saccharomyces cerevisiae YLL010C   Psr1p
Schistosoma japonicum Sjp_0083070   ko:K01090 protein phosphatase [EC3.1.3.16], putative
Schistosoma japonicum Sjp_0200010   CTD small phosphatase-like protein, putative
Schistosoma mansoni Smp_181170   nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)
Schistosoma mansoni Smp_133240   hypothetical protein
Schistosoma mansoni Smp_154650   nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)
Schmidtea mediterranea mk4.002930.11  
Schmidtea mediterranea mk4.003785.04  
Schmidtea mediterranea mk4.000028.05  
Trypanosoma brucei gambiense Tbg972.3.2050   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.2110   Mitochondrial import inner membrane translocase subunit TIM50
Trypanosoma congolense TcIL3000_0_10200   TFIIF-stimulated CTD phosphatase, putative
Trypanosoma congolense TcIL3000_3_1220   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507081.90   hypothetical protein, conserved
Toxoplasma gondii TGME49_243990   Dullard family phosphatase domain-containing protein
Theileria parva TP03_0026   nuclear LIM interactor-interacting factor 1, putative
Trichomonas vaginalis TVAG_460790   dullard protein, putative
Trichomonas vaginalis TVAG_225200   nuclear lim interactor-interacting factor, putative
Trichomonas vaginalis TVAG_157570   dullard protein, putative
Trichomonas vaginalis TVAG_053750   nuclear lim interactor-interacting factor, putative
Trichomonas vaginalis TVAG_162430   dullard protein, putative
Trichomonas vaginalis TVAG_084510   nuclear lim interactor-interacting factor, putative
Trichomonas vaginalis TVAG_390460   nuclear lim interactor-interacting factor, putative

Essentiality

LinJ.25.2110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.2110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.2110 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.3.2110 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1115500 Plasmodium berghei Slow plasmo
PBANKA_1403300 Plasmodium berghei Slow plasmo
TGME49_243990 Toxoplasma gondii Essentiality uncertain sidik
TGME49_243990 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LinJ.25.2110 (Leishmania infantum), hypothetical protein, conserved
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