pI: 7.0736 |
Length (AA): 303 |
MW (Da): 35362 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 302 | 3qhw (B) | 172 | 432 | 35.00 | 0 | 1 | 1.31229 | -0.91 |
22 | 299 | 5lqf (B) | 168 | 420 | 37.00 | 0 | 1 | 1.25819 | -0.6 |
31 | 268 | 3g33 (B) | 38 | 251 | 28.00 | 0 | 1 | 1.05988 | -0.59 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126649)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G25380 | 1 |
Arabidopsis thaliana | AT1G20610 | 3 |
Arabidopsis thaliana | AT1G47230 | 4 |
Arabidopsis thaliana | AT1G44110 | 1 |
Arabidopsis thaliana | AT1G47220 | 3 |
Arabidopsis thaliana | AT1G47210 | 2 |
Arabidopsis thaliana | AT5G43080 | 1 |
Arabidopsis thaliana | AT1G76310 | 4 |
Arabidopsis thaliana | AT4G37490 | 1 |
Arabidopsis thaliana | AT5G06150 | cyclin-B1-2 |
Arabidopsis thaliana | AT5G11300 | cyclin-A2-2 |
Arabidopsis thaliana | AT4G35620 | 2 |
Arabidopsis thaliana | AT2G17620 | 1 |
Arabidopsis thaliana | AT3G11520 | 3 |
Arabidopsis thaliana | AT1G34460 | 5 |
Brugia malayi | Bm1_27665 | Cyclin, N-terminal domain containing protein |
Brugia malayi | Bm1_12035 | Cyclin, N-terminal domain containing protein |
Candida albicans | CaO19.9021 | likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction |
Candida albicans | CaO19.7186 | likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition |
Candida albicans | CaO19.1446 | likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction |
Candida albicans | CaO19_7186 | hypothetical protein |
Caenorhabditis elegans | CELE_ZK507.6 | Protein CYA-1 |
Caenorhabditis elegans | CELE_ZC168.4 | Protein CYB-1 |
Caenorhabditis elegans | CELE_Y43E12A.1 | Protein CYB-2.1 |
Caenorhabditis elegans | CELE_H31G24.4 | Protein CYB-2.2 |
Cryptosporidium hominis | Chro.30456 | mitotic cyclin-CYC2 |
Cryptosporidium parvum | cgd3_4050 | cyclin |
Dictyostelium discoideum | DDB_G0275493 | G2/M-specific cyclinB |
Drosophila melanogaster | Dmel_CG5940 | Cyclin A |
Drosophila melanogaster | Dmel_CG3510 | Cyclin B |
Echinococcus granulosus | EgrG_001070150 | cyclin B |
Entamoeba histolytica | EHI_030880 | cyclin, putative |
Echinococcus multilocularis | EmuJ_001070150 | cyclin B |
Giardia lamblia | GL50803_3977 | G2/mitotic-specific cyclin B |
Homo sapiens | ENSG00000133101 | cyclin A1 |
Homo sapiens | ENSG00000134057 | cyclin B1 |
Homo sapiens | ENSG00000145386 | cyclin A2 |
Homo sapiens | ENSG00000157456 | cyclin B2 |
Leishmania braziliensis | LbrM.32.3610 | CYC2-like cyclin, putative,cyclin 6, putative |
Leishmania braziliensis | LbrM.25.1330 | cyclin |
Leishmania donovani | LdBPK_323520.1 | CYC2-like cyclin, putative |
Leishmania donovani | LdBPK_251530.1 | cyclin |
Leishmania infantum | LinJ.25.1530 | cyclin |
Leishmania infantum | LinJ.32.3520 | CYC2-like cyclin, putative,cyclin 6, putative |
Leishmania major | LmjF.25.1470 | cyclin |
Leishmania major | LmjF.32.3320 | CYC2-like cyclin, putative,cyclin 6, putative |
Leishmania mexicana | LmxM.31.3320 | CYC2-like cyclin, putative,cyclin 6, putative |
Leishmania mexicana | LmxM.25.1470 | cyclin |
Loa Loa (eye worm) | LOAG_13943 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08137 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07984 | hypothetical protein |
Mus musculus | ENSMUSG00000032218 | cyclin B2 |
Mus musculus | 434175 | predicted gene 5593 |
Mus musculus | 102643276 | G2/mitotic-specific cyclin-B1-like |
Mus musculus | ENSMUSG00000041431 | cyclin B1 |
Mus musculus | ENSMUSG00000027715 | cyclin A2 |
Mus musculus | ENSMUSG00000027793 | cyclin A1 |
Oryza sativa | 4352642 | Os12g0581800 |
Oryza sativa | 4333422 | Os03g0607600 |
Oryza sativa | 9268829 | Os12g0298950 |
Oryza sativa | 4339185 | Os05g0493500 |
Oryza sativa | 4336670 | Os04g0563700 |
Oryza sativa | 4324288 | Os01g0233500 |
Oryza sativa | 4327547 | Os01g0805600 |
Oryza sativa | 4326914 | Os01g0281200 |
Oryza sativa | 9268872 | Os05g0501350 |
Oryza sativa | 4342121 | Os06g0726800 |
Onchocerca volvulus | OVOC12051 |
|
Saccharomyces cerevisiae | YLR210W | Clb4p |
Saccharomyces cerevisiae | YPR119W | Clb2p |
Saccharomyces cerevisiae | YGR108W | Clb1p |
Saccharomyces cerevisiae | YDL155W | Clb3p |
Saccharomyces cerevisiae | YGR109C | Clb6p |
Schistosoma japonicum | Sjp_0035030 | ko:K05868 cyclin B, putative |
Schistosoma mansoni | Smp_082490 | cyclin B |
Schmidtea mediterranea | mk4.013209.00 | CyclinB-like protein |
Schmidtea mediterranea | mk4.000226.04 | Cyclin B-1 |
Schmidtea mediterranea | mk4.000312.15 | CyclinE-like protein |
Schmidtea mediterranea | mk4.000679.02 | |
Trypanosoma brucei gambiense | Tbg972.11.18860 | cyclin 6,mitotic cyclin |
Trypanosoma brucei | Tb927.11.16720 | mitotic cyclin 6 |
Trypanosoma congolense | TcIL3000.11.16610 | mitotic cyclin 6 |
Trypanosoma congolense | TcIL3000_3_270 | Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative |
Trypanosoma cruzi | TcCLB.506711.30 | cyclin, putative |
Trypanosoma cruzi | TcCLB.507089.260 | CYC2-like cyclin, putative |
Trypanosoma cruzi | TcCLB.509455.140 | cyclin, putative |
Trypanosoma cruzi | TcCLB.511025.120 | cyclin 6, putative |
Trichomonas vaginalis | TVAG_335410 | cyclins, putative |
Trichomonas vaginalis | TVAG_494460 | cyclins, putative |
Trichomonas vaginalis | TVAG_486130 | cyclins, putative |
Trichomonas vaginalis | TVAG_371670 | cyclins, putative |
Trichomonas vaginalis | TVAG_187920 | cyclin B, putative |
Trichomonas vaginalis | TVAG_488140 | cyclins, putative |
Trichomonas vaginalis | TVAG_266050 | cyclin B, putative |
Trichomonas vaginalis | TVAG_309310 | cyclin A, putative |
Trichomonas vaginalis | TVAG_468150 | cyclin B, putative |
Trichomonas vaginalis | TVAG_121680 | cyclin B, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.8460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.8460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.8460 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.8460 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK507.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZC168.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZC168.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y43E12A.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y43E12A.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H31G24.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H31G24.4 | Caenorhabditis elegans | larval arrest | wormbase |
YDL155W | Saccharomyces cerevisiae | inviable | yeastgenome |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | cyclin A1 | Compounds | References |
Homo sapiens | cyclin B1 | Compounds | References |
Homo sapiens | cyclin A2 | Compounds | References |
Asterina pectinifera | G2/mitotic-specific cyclin-B | Compounds | References |
Rattus norvegicus | G2/mitotic-specific cyclin B1 | Compounds | References |
Homo sapiens | cyclin B2 | Compounds | References |