Detailed view for LinJ.09.0450

Basic information

TDR Targets ID: 441830
Leishmania infantum, protein kinase, putative
Source Database / ID: 

pI: 8.7561 | Length (AA): 469 | MW (Da): 53210 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 98 3s6l (A) 36 128 35.00 0.88 0.09 0.218433 1.34
110 462 4wnk (A) 159 472 21.00 0 1 0.776365 0.39
111 445 3nr9 (A) 144 481 35.00 0 1 1.15399 -0.57
127 445 2x7g (A) 86 699 32.00 0 1 1.07587 -0.63
259 340 2xnm (A) 141 209 39.00 0.05 0.17 0.0546401 1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126990)

Species Accession Gene Product
Arabidopsis thaliana AT4G32660   protein kinase AME3
Arabidopsis thaliana AT3G53570   serine/threonine-protein kinase AFC1
Arabidopsis thaliana AT4G24740   LAMMER-type protein kinase AFC2
Babesia bovis BBOV_IV001230   protein serine/threonine kinase 1
Brugia malayi Bm1_30560   Protein kinase domain containing protein
Candida albicans CaO19.4979   Serine/threonine protein kinase
Candida albicans CaO19.12446   Serine/threonine protein kinase
Caenorhabditis elegans CELE_E02H4.3   Protein TAG-172, isoform B
Cryptosporidium hominis Chro.50371   serine/threonine kinase-1
Cryptosporidium parvum cgd5_250   serine/threonine kinase-1
Dictyostelium discoideum DDB_G0281179   CLK family protein kinase
Drosophila melanogaster Dmel_CG42320   Darkener of apricot
Echinococcus granulosus EgrG_000340100   hypothetical protein
Echinococcus granulosus EgrG_000482500   dual specificity protein kinase clk2
Echinococcus multilocularis EmuJ_000340100  
Echinococcus multilocularis EmuJ_000482500   dual specificity protein kinase clk2
Giardia lamblia GL50803_92741   Kinase, CMGC CLK
Homo sapiens ENSG00000013441   CDC-like kinase 1
Homo sapiens ENSG00000179335   CDC-like kinase 3
Homo sapiens ENSG00000113240   CDC-like kinase 4
Homo sapiens ENSG00000176444   CDC-like kinase 2
Leishmania braziliensis LbrM.09.0420   protein kinase, putative
Leishmania infantum LinJ.09.0460   protein kinase, putative
Leishmania infantum LinJ.09.0450   protein kinase, putative
Leishmania major LmjF.09.0410   protein kinase, putative
Leishmania major LmjF.09.0400   protein kinase, putative
Leishmania mexicana LmxM.09.0400   protein kinase, putative
Leishmania mexicana LmxM.09.0410  
Loa Loa (eye worm) LOAG_05523   hypothetical protein
Loa Loa (eye worm) LOAG_05522   CMGC/CLK protein kinase
Mus musculus ENSMUSG00000032316   CDC-like kinase 3
Mus musculus ENSMUSG00000068917   CDC-like kinase 2
Mus musculus ENSMUSG00000020385   CDC like kinase 4
Mus musculus ENSMUSG00000026034   CDC-like kinase 1
Neospora caninum NCLIV_048210   hypothetical protein
Oryza sativa 4326374   Os01g0590900
Oryza sativa 4327372   Os01g0837900
Plasmodium berghei PBANKA_1309200   serine/threonine kinase-1, putative
Plasmodium falciparum PF3D7_1445400   protein serine/threonine kinase-1
Plasmodium knowlesi PKNH_1236900   serine/threonine kinase-1, putative
Plasmodium vivax PVX_118220   serine/threonine kinase-1, putative
Plasmodium yoelii PY06874   protein serine/threonine kinase-1
Saccharomyces cerevisiae YLL019C   Kns1p
Schistosoma japonicum Sjp_0013010   expressed protein
Schistosoma japonicum Sjp_0080140   Serine/threonine-protein kinase Doa, putative
Schistosoma japonicum Sjp_0019720   ko:K08823 CDC-like kinase, putative
Schistosoma mansoni Smp_058620   serine/threonine protein kinase
Schistosoma mansoni Smp_134560   serine/threonine protein kinase
Schmidtea mediterranea mk4.020391.00   Serine/threonine kinase
Schmidtea mediterranea mk4.044861.00   Serine/threonine kinase
Schmidtea mediterranea mk4.002325.02   Serine/threonine kinase
Schmidtea mediterranea mk4.002777.00  
Schmidtea mediterranea mk4.015470.00   Serine/threonine kinase
Schmidtea mediterranea mk4.025279.00   Serine/threonine kinase
Schmidtea mediterranea mk4.000061.05   Serine/threonine kinase
Schmidtea mediterranea mk4.003857.01   Serine/threonine kinase
Trypanosoma brucei gambiense Tbg972.11.13870   protein kinase, putative
Trypanosoma brucei Tb927.11.12410   kinetoplastid kinetochore protein 10
Trypanosoma brucei Tb927.11.12420   kinetoplastid kinetochore protein 19
Trypanosoma congolense TcIL3000.11.13030   kinetoplastid kinetochore protein 10, putative
Trypanosoma congolense TcIL3000_0_20360   kinetoplastid kinetochore protein, putative
Trypanosoma congolense TcIL3000_0_27770   kinetoplastid kinetochore protein, putative
Trypanosoma cruzi TcCLB.511127.330   kinetoplastid kinetochore protein 19, putative
Trypanosoma cruzi TcCLB.509027.60   kinetoplastid kinetochore protein 10, putative
Trypanosoma cruzi TcCLB.511127.320   kinetoplastid kinetochore protein 10, putative
Trypanosoma cruzi TcCLB.509027.70   kinetoplastid kinetochore protein 19, putative
Toxoplasma gondii TGME49_224480   cell-cycle-associated protein kinase CLK, putative
Theileria parva TP01_0149   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_246960   CMGC family protein kinase

Essentiality

LinJ.09.0450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4250 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.4250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4250 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4250 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.4230 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.4230 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.4230 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4230 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1309200 Plasmodium berghei Essential plasmo
TGME49_224480 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CDC-like kinase 1 Compounds References
Homo sapiens CDC-like kinase 2 Compounds References
Mus musculus CDC-like kinase 2 Compounds References
Homo sapiens CDC-like kinase 4 Compounds References
Mus musculus CDC-like kinase 3 Compounds References
Mus musculus CDC like kinase 4 Compounds References
Mus musculus CDC-like kinase 1 Compounds References
Homo sapiens CDC-like kinase 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 24.9% 334 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.4% 335 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 23.0% 300 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.8% 349 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 23.1% 347 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.5% 324 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.8% 322 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 23.9% 247 aa Compounds References
Patiria pectinifera Cdc2 300 aa 23.6% 318 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LinJ.09.0450 (Leishmania infantum), protein kinase, putative
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