Detailed view for LmxM.29.2900

Basic information

TDR Targets ID: 443895
Leishmania mexicana, aldehyde dehydrogenase, putative
Source Database / ID: 

pI: 7.8582 | Length (AA): 585 | MW (Da): 63915 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00171   Aldehyde dehydrogenase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 512 4q71 (A) 457 970 19.00 0 1 1.03591 0.83
42 513 4pz2 (A) 30 500 32.00 0 1 1.20774 -0.4
48 542 4jz6 (A) 3 483 26.00 0.0016 1 1.15135 -0.03
51 545 2d4e (A) 30 512 28.00 0.00000049 1 1.11435 0.24
63 504 1t90 (A) 17 457 24.00 0 1 1.06646 -0.2
73 527 3prl (A) 36 478 34.00 0 1 1.14368 -0.15
86 545 3sza (A) 1 447 31.00 0 1 1.12522 -0.08
87 527 3etf (A) 30 462 31.00 0 1 1.19075 -0.66
88 545 1ad3 (A) 3 447 30.00 0 1 1.13581 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131364)

Species Accession Gene Product
Arabidopsis thaliana AT3G66658   aldehyde dehydrogenase 22A1
Candida albicans CaO19.9421   similarity to aldehyde dehydrogenase
Candida albicans CaO19.1865   similarity to aldehyde dehydrogenase
Dictyostelium discoideum DDB_G0279613   aldehyde dehydrogenase
Leishmania braziliensis LbrM.30.2880   aldehyde dehydrogenase, putative
Leishmania donovani LdBPK_302920.1   aldehyde dehydrogenase, putative
Leishmania infantum LinJ.30.2920   aldehyde dehydrogenase, putative
Leishmania major LmjF.30.2900   aldehyde dehydrogenase, putative
Leishmania mexicana LmxM.29.2900   aldehyde dehydrogenase, putative
Oryza sativa 9268600   Os07g0689150
Oryza sativa 4344358   Os07g0688800
Saccharomyces cerevisiae YHR039C   Msc7p
Trypanosoma brucei gambiense Tbg972.6.4000   aldehyde dehydrogenase, putative
Trypanosoma brucei Tb927.6.4210   aldehyde dehydrogenase, putative
Trypanosoma cruzi TcCLB.506943.4   aldehyde dehydrogenase, putative

Essentiality

LmxM.29.2900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.4210 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.4210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.4210 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Aldehyde dehydrogenase, cytosolic 1 501 aa 31.7% 492 aa Compounds References
Rattus norvegicus Aldehyde dehydrogenase 1A1 501 aa 32.6% 491 aa Compounds References
Rattus norvegicus Aldehyde dehydrogenase 519 aa 31.7% 448 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.29.2900 (Leishmania mexicana), aldehyde dehydrogenase, putative
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