Detailed view for LmxM.04.1160

Basic information

TDR Targets ID: 443935
Leishmania mexicana, fructose-1,6-bisphosphatase, cytosolic, putative
Source Database / ID: 

pI: 8.8456 | Length (AA): 320 | MW (Da): 35244 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00316   Fructose-1-6-bisphosphatase, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042132   fructose-bisphosphatase activity  
GO:0042578   phosphoric ester hydrolase activity  
GO:0016791   phosphoric monoester hydrolase activity  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 307 5ofu (A) 32 338 95.00 0 1 2.12028 -1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127400)

Species Accession Gene Product
Arabidopsis thaliana AT1G43670   fructose-1,6-bisphosphatase
Arabidopsis thaliana AT3G54050   fructose-1,6-bisphosphatase
Brugia malayi Bm1_37105   fructose-1,6-bisphosphatase
Candida albicans CaO19.6178   similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase
Caenorhabditis elegans CELE_K07A3.1   Protein FBP-1
Dictyostelium discoideum DDB_G0270836   D-fructose-1,6-bisphosphate 1-phosphohydrolase
Drosophila melanogaster Dmel_CG31692   fructose-1,6-bisphosphatase
Escherichia coli b4232   fructose-1,6-bisphosphatase I
Echinococcus granulosus EgrG_000261600   fructose 16 bisphosphatase 1
Echinococcus multilocularis EmuJ_000261600   fructose 1,6 bisphosphatase 1
Homo sapiens ENSG00000130957   fructose-1,6-bisphosphatase 2
Homo sapiens ENSG00000165140   fructose-1,6-bisphosphatase 1
Leishmania braziliensis LbrM.04.1170   fructose-1,6-bisphosphatase, cytosolic, putative
Leishmania donovani LdBPK_041170.1   fructose-1,6-bisphosphatase, cytosolic, putative
Leishmania infantum LinJ.04.1170   fructose-1,6-bisphosphatase, cytosolic, putative
Leishmania major LmjF.04.1160  
Leishmania mexicana LmxM.04.1160   fructose-1,6-bisphosphatase, cytosolic, putative
Loa Loa (eye worm) LOAG_08442   fructose-1,6-bisphosphatase
Mus musculus ENSMUSG00000069805   fructose bisphosphatase 1
Mus musculus ENSMUSG00000021456   fructose bisphosphatase 2
Neospora caninum NCLIV_065240   Fructose-1 6-biphosphatase, related
Oryza sativa 4332364   Os03g0267300
Oryza sativa 4325071   Os01g0866400
Saccharomyces cerevisiae YLR377C   fructose 1,6-bisphosphate 1-phosphatase
Schistosoma japonicum Sjp_0215060   ko:K03841 fructose-1,6-bisphosphatase I, putative
Schistosoma mansoni Smp_097370   fructose-16-bisphosphatase-related
Schmidtea mediterranea mk4.009209.00   Fructose-1,6-bisphosphatase
Schmidtea mediterranea mk4.005944.01  
Schmidtea mediterranea mk4.004250.00  
Schmidtea mediterranea mk4.002529.00   Fructose-1,6-bisphosphatase
Trypanosoma brucei gambiense Tbg972.9.4810   fructose-1,6-bisphosphate, cytosolic, putative
Trypanosoma brucei Tb927.9.8720   fructose-1,6-bisphosphatase
Trypanosoma congolense TcIL3000_9_3050   fructose-1,6-bisphosphate, cytosolic, putative
Trypanosoma cruzi TcCLB.506649.70   fructose-1,6-bisphosphatase, cytosolic, putative
Trypanosoma cruzi TcCLB.508351.10   fructose-1,6-bisphosphatase, cytosolic, putative
Toxoplasma gondii TGME49_247510   fructose-bisphospatase II

Essentiality

LmxM.04.1160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.0540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.0540 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.0540 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b4232 Escherichia coli non-essential goodall
TGME49_247510 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Fructose-1,6-bisphosphatase Compounds References
Rattus norvegicus Fructose-1,6-bisphosphatase Compounds References
Homo sapiens fructose-1,6-bisphosphatase 1 Compounds References
Mus musculus fructose bisphosphatase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.04.1160 (Leishmania mexicana), fructose-1,6-bisphosphatase, cytosolic, putative
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