Detailed view for LmxM.33.2190

Basic information

TDR Targets ID: 445769
Leishmania mexicana, dual specificity protein phosphatase, putative
Source Database / ID: 

pI: 6.0507 | Length (AA): 1382 | MW (Da): 152794 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00782   Dual specificity phosphatase, catalytic domain
PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0008138   protein tyrosine/serine/threonine phosphatase activity  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004725   protein tyrosine phosphatase activity  
GO:0004672   protein kinase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 364 3q5i (A) 51 356 26.00 0.0000001 1 0.317913 0.19
264 341 3aln (C) 289 366 39.00 0.0065 0.77 0.10604 0.7
308 343 2i6l (A) 282 317 19.00 0 0.12 0.150249 0.37
399 721 3v5w (A) 186 522 19.00 0 1 0.394919 0.15
440 822 5t6a (A) 80 498 15.00 0 0.7 0.372735 0.51
445 709 3nie (A) 63 413 15.00 0 0.98 0.209351 -0.23
445 707 5awm (A) 57 357 18.00 0 1 0.250904 -0.14
453 682 2x4f (A) 145 373 20.00 0 1 0.430025 -0.57
779 1200 4u7l (A) 1 433 20.00 0.000000000032 1 0.400955 0.91
1003 1099 4nkh (A) 291 373 47.00 0.000041 0.87 0.398788 0.41
1022 1104 4lsc (A) 98 184 35.00 0.018 1 0.506658 -0.64
1200 1359 3cm3 (A) 1007 1166 22.00 0 1 0.372974 -0.43
1223 1373 2hcm (A) 8 158 29.00 0 1 0.645862 -1.7
1226 1364 6apx (A) 1174 1312 38.00 0 1 0.718179 -1.75
1226 1369 2oud (A) 322 467 39.00 0 1 0.702397 -1.63
1226 1364 2nt2 (A) 308 446 32.00 0 1 0.643779 -1.64
1226 1379 1yz4 (A) 5 156 32.00 0 1 0.629033 -1.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138464)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0278445   leucine-rich repeat-containing protein
Dictyostelium discoideum DDB_G0269918   leucine-rich repeat-containing protein
Dictyostelium discoideum DDB_G0270688   leucine-rich repeat-containing protein
Entamoeba histolytica EHI_099820   leucine rich repeat and phosphatase domain containing protein
Leishmania braziliensis LbrM.20.1690   dual specificity protein phosphatase, putative
Leishmania donovani LdBPK_341950.1   kinatase, putative
Leishmania infantum LinJ.34.1950   dual specificity protein phosphatase, putative
Leishmania major LmjF.34.2190   dual specificity protein phosphatase, putative
Leishmania mexicana LmxM.33.2190   dual specificity protein phosphatase, putative
Trypanosoma brucei gambiense Tbg972.4.2420   dual specificity protein phosphatase, putative
Trypanosoma brucei Tb927.4.2460   kinatase, putative
Trypanosoma brucei Tb11.v5.0751   dual specificity protein phosphatase, putative
Trypanosoma congolense TcIL3000_4_2340   kinatase, putative
Trypanosoma cruzi TcCLB.510949.10   kinatase, putative
Trypanosoma cruzi TcCLB.506559.190   kinatase, putative

Essentiality

LmxM.33.2190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.2460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.2460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.2460 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.2460 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 22.3% 256 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 22.6% 159 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 21.1% 180 aa Compounds References
Patiria pectinifera Cdc2 300 aa 22.7% 256 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.33.2190 (Leishmania mexicana), dual specificity protein phosphatase, putative
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