pI: 9.3512 |
Length (AA): 447 |
MW (Da): 48811 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
90 | 447 | 2j63 (A) | 90 | 447 | 96.00 | 0 | 1 | 1.90579 | -1.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126768)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G48425 | DNAse I-like superfamily protein |
Arabidopsis thaliana | AT2G41460 | apurinic endonuclease-redox protein |
Arabidopsis thaliana | AT4G36050 | endonuclease/exonuclease/phosphatase family protein |
Brugia malayi | Bm1_24435 | exodeoxyribonuclease III family protein |
Candida albicans | CaO19.9394 | similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease |
Candida albicans | CaO19.1836 | similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease |
Caenorhabditis elegans | CELE_R09B3.1 | Protein EXO-3, isoform B |
Cryptosporidium hominis | Chro.20012 | dna-(apurinic or apyrimidinic site) lyase |
Cryptosporidium parvum | cgd2_40 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0277701 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3178 | Recombination repair protein 1 |
Escherichia coli | b1749 | exonuclease III |
Echinococcus granulosus | EgrG_000078600 | DNA apurinic or apyrimidinic site lyase |
Entamoeba histolytica | EHI_046670 | exodeoxyribonuclease III, putative |
Echinococcus multilocularis | EmuJ_000078600 | DNA (apurinic or apyrimidinic site) lyase |
Giardia lamblia | GL50803_9834 | Endonuclease/Exonuclease/phosphatase |
Homo sapiens | ENSG00000100823 | APEX nuclease (multifunctional DNA repair enzyme) 1 |
Homo sapiens | 27301 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 |
Leishmania braziliensis | LbrM.16.0670 | apurinic/apyrimidinic endonuclease-redox protein |
Leishmania donovani | LdBPK_160680.1 | apurinic/apyrimidinic endonuclease-redox protein |
Leishmania infantum | LinJ.16.0680 | apurinic/apyrimidinic endonuclease-redox protein |
Leishmania major | LmjF.16.0680 | apurinic/apyrimidinic endonuclease-redox protein |
Leishmania mexicana | LmxM.16.0680 | apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease |
Loa Loa (eye worm) | LOAG_01360 | exodeoxyribonuclease III family protein |
Mus musculus | ENSMUSG00000035960 | apurinic/apyrimidinic endonuclease 1 |
Mus musculus | ENSMUSG00000025269 | apurinic/apyrimidinic endonuclease 2 |
Mus musculus | 102642865 | DNA-(apurinic or apyrimidinic site) lyase-like |
Mycobacterium tuberculosis | Rv0427c | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) |
Mycobacterium ulcerans | MUL_1374 | exodeoxyribonuclease III protein XthA |
Neospora caninum | NCLIV_059670 | hypothetical protein |
Oryza sativa | 4327961 | Os01g0801100 |
Oryza sativa | 4327960 | Os01g0801000 |
Oryza sativa | 4351982 | Os12g0279600 |
Oryza sativa | 4347697 | Os09g0536000 |
Plasmodium berghei | PBANKA_0404100 | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative |
Plasmodium falciparum | PF3D7_0305600 | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative |
Plasmodium knowlesi | PKNH_0837100 | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative |
Plasmodium vivax | PVX_119405 | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative |
Plasmodium yoelii | PY02645 | putative AP endonuclease-related |
Saccharomyces cerevisiae | YBL019W | DNA-(apurinic or apyrimidinic site) lyase APN2 |
Schistosoma japonicum | Sjp_0123800 | DNA-(apurinic or apyrimidinic site) lyase 2, putative |
Schistosoma japonicum | Sjp_0035270 | ko:K10772 AP endonuclease 2, putative |
Schistosoma japonicum | Sjp_0006220 | ko:K10771 AP endonuclease 1, putative |
Schistosoma japonicum | Sjp_0305970 | DNA-(apurinic or apyrimidinic site) lyase 2, putative |
Schistosoma mansoni | Smp_167500 | ap endonuclease |
Schistosoma mansoni | Smp_051320 | ap endonuclease |
Schmidtea mediterranea | mk4.002319.01 | Exonuclease III homolog |
Schmidtea mediterranea | mk4.036851.00 | DNA-(apurinic or apyrimidinic site) lyase |
Schmidtea mediterranea | mk4.006369.00 | Ap endonuclease, putative |
Schmidtea mediterranea | mk4.054051.01 | |
Trypanosoma brucei gambiense | Tbg972.8.5480 | apurinic/apyrimidinic endonuclease, putative |
Trypanosoma brucei | Tb927.8.5510 | apurinic/apyrimidinic endonuclease, putative |
Trypanosoma congolense | TcIL3000_8_5320 | apurinic/apyrimidinic endonuclease, putative |
Trypanosoma cruzi | TcCLB.509901.170 | apurinic/apyrimidinic endonuclease |
Trypanosoma cruzi | TcCLB.507083.30 | apurinic/apyrimidinic endonuclease, putative |
Toxoplasma gondii | TGME49_216600 | exonuclease III APE |
Treponema pallidum | TP0125 | exodeoxyribonuclease (exoA) |
Theileria parva | TP03_0022 | hypothetical protein |
Trichomonas vaginalis | TVAG_116970 | ap endonuclease, putative |
Trichomonas vaginalis | TVAG_015160 | ap endonuclease, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0729 | exonuclease III |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5510 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5510 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1749 | Escherichia coli | non-essential | goodall |
CELE_R09B3.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R09B3.1 | Caenorhabditis elegans | larval arrest | wormbase |
PBANKA_0404100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_216600 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Compounds | References |