Detailed view for LmxM.15.1200

Basic information

TDR Targets ID: 449590
Leishmania mexicana, protein kinase, putative
Source Database / ID: 

pI: 6.3167 | Length (AA): 2700 | MW (Da): 287287 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain
PF00069   Protein kinase domain
PF00989   PAS fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
292 596 4din (B) 58 374 30.00 0 1 0.382563 0.66
304 464 3fhi (B) 92 241 29.00 0 0.96 0.27603 -0.02
306 605 2qvs (B) 92 390 27.00 0 1 0.312711 0.44
338 1566 5dyk (A) 40 800 22.00 0 1 -0.0812148 1.82
339 459 5c8w (A) 151 269 21.00 0 1 0.428415 -1.08
467 583 2byv (E) 330 443 22.00 0.0000000000064 0.71 0.254933 0.15
1262 1597 3uto (A) 122 445 22.00 0 1 0.358044 0.02
1286 1598 3a7i (A) 14 298 32.00 0 1 0.447526 -0.36
1294 1598 3c0g (B) 10 305 23.00 0 1 0.336563 -0.28
1296 1753 3lij (A) 62 495 22.00 0 1 0.26323 0.72
1301 1559 4bf2 (B) 685 933 42.00 0 1 0.340426 0.17
1302 1627 6ao5 (A) 33 447 32.00 0 1 0.219141 0.33
1756 1820 5ig0 (A) 354 418 20.00 0.00018 0.04 0.345674 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_160588)

Species Accession Gene Product
Leishmania braziliensis LbrM.15.1140   protein kinase, putative
Leishmania donovani LdBPK_151180.1   protein kinase, putative
Leishmania infantum LinJ.15.1180   protein kinase, putative
Leishmania major LmjF.15.1200   protein kinase, putative
Leishmania mexicana LmxM.15.1200   protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 21.4% 271 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.8% 326 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.5% 269 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.6% 290 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 26.8% 205 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 26.9% 193 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.15.1200 (Leishmania mexicana), protein kinase, putative
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