Detailed view for PF3D7_0615100

Basic information

TDR Targets ID: 4502
Plasmodium falciparum, enoyl-acyl carrier reductase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4775 | Length (AA): 432 | MW (Da): 49762 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0016631   enoyl-[acyl-carrier-protein] reductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006633   fatty acid biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
93 432 1jw7 (A) 2 263 25.00 0 1 0.72 -0.14
366 425 1nhw (C) 366 425 99.99 0 0.7 1.26 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1NHG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1NHW:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1NNU:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1UH5:
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PDB tag
  • 1V35:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1VRW:
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PDB tag
  • 1ZSN:
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PDB tag
  • 1ZW1:
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PDB tag
  • 1ZXB:
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PDB tag
  • 1ZXL:
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PDB tag
  • 2FOI:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2NQ8:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2O2Y:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2OL4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2OOS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2OP0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2OP1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3AM3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3AM4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3AM5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3F4B:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LSY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LT0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LT1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LT2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LT4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4IGE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4IGF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Oocyst, Female Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130466)

Species Accession Gene Product
Arabidopsis thaliana AT2G05990   enoyl-[acyl-carrier-protein] reductase [NADH]
Chlamydia trachomatis CT_104   enoyl-acyl-carrier protein reductase
Escherichia coli b1288   enoyl-[acyl-carrier-protein] reductase, NADH-dependent
Mycobacterium leprae ML1806c   NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)
Mycobacterium tuberculosis Rv1484   NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)
Mycobacterium ulcerans MUL_1492   enoyl-(acyl carrier protein) reductase
Neospora caninum NCLIV_066970   enoyl-acyl carrier reductase, putative
Oryza sativa 4346596   Os09g0277800
Oryza sativa 4345286   Os08g0327400
Plasmodium berghei PBANKA_1229800   enoyl-acyl carrier reductase
Plasmodium falciparum PF3D7_0615100   enoyl-acyl carrier reductase
Plasmodium knowlesi PKNH_1134900   enoyl-acyl carrier reductase, putative
Plasmodium vivax PVX_113890   enoyl-acyl carrier protein reductase
Plasmodium yoelii PY03846   enoyl-acyl carrier reductase
Toxoplasma gondii TGME49_251930   enoyl-acyl carrier reductase ENR
Trichomonas vaginalis TVAG_214820   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0470   enoyl-ACP reductase

Essentiality

PF3D7_0615100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1508 Mycobacterium tuberculosis non-essential nmpdr
b1288 Escherichia coli essential goodall
TGME49_251930 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 60396  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 11175846 11239932 11792710

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.8

Known modulators for this target

100 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Staphylococcus aureus Enoyl-ACP reductase Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase Compounds References
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Enoyl-[acyl-carrier-protein] reductase [NADH] Compounds References
Staphylococcus aureus (strain NCTC 8325) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] Compounds References
Escherichia coli enoyl-[acyl-carrier-protein] reductase, NADH-dependent Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] Compounds References
Toxoplasma gondii enoyl-acyl carrier reductase ENR Compounds References
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Compounds References
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1329 1 1
0.6069 1 1
0.0223 0.6281 1
0.038 0.4787 0.5
0.1494 0.3372 1
0.0179 0.3104 1
0.0223 0.5133 0.8105
0.0381 0.68 1
0.1192 0.5258 1
0.1428 1 1
0.0447 0.5 0.5
0.0201 1 0.5
0.037 0.2511 1
0.0372 0.547 1
0.036 0.8704 0.5
0.1368 0.8505 1
0.2229 1 1
0.0724 0.4013 1
0.1386 1 1
0.039 0.279 1
0.0188 0.6329 1
0.0217 1 0.5
0.1631 0.564 1
0.0399 0.547 1
0.0143 0.4063 0.5
0.0736 0.9713 1
0.0365 1 1
0.608 1 1
0.2026 1 1
0.1028 0.4205 1
0.0187 0.5555 1
0.0186 0.5394 1
0.139 1 1
0.0745 0.9359 1
0.0201 0.5078 1
0.0377 1 1
0.0192 0.5 0.5
0.0183 0.4434 1
0.0399 1 0.5
0.0399 0.5694 1
0.0186 1 0.5
0.0574 0.845 1
0.0184 0.3557 1
0.1209 1 1
0.0182 0.2602 0.5
0.0959 1 1
0.1107 0.769 1
0.4413 0.2748 1
0.0322 0.4604 1
0.0179 0.9034 1
0.1562 0.9418 1
0.0977 1 1
0.0219066 0.5 0.5
0.0376 1 0.5
0.0223 0.5 0.5
0.0183 0.5248 1
0.2147 1 1
0.0388 0.547 1
0.1164 0.5987 1
0.1478 1 1
0.0583 0.3517 1
0.3656 1 1
0.1754 1 1
0.0363 1 1
0.2075 1 1
0.0182 1 0.5
0.0762 0.2955 1
0.0181 0.5235 1
0.1797 1 1
0.0411 0.4204 1
0.0223 1 0.5
0.0185 1 1
0.3209 1 1
0.0364 0.5 0.5
0.0569 1 1
0.0373 0.7227 0.5
0.0214 0.465 1
0.022 0.2537 0.4286
0.076 0.9374 1
0.1142 1 1
0.1036 1 1
0.0447 0.5 0.5
0.018 0.6678 0.5
0.1097 0.328 1
0.1028 0.4205 1
0.0223 0.8513 1
0.074 1 1
0.0757 0.9119 1
0.1502 0.7066 1
0.0568 0.2672 1
0.7141 0.7479 1
0.0223 1 0.5
0.0561 1 1
0.0573 0.714 1
0.16 1 0.5
0.0918 0.5616 1
0.2098 0.3532 1
0.0569 1 1
0.0389 0.4722 1
0.0382844 1 0.5
0.055 0.6489 1
0.0389 0.7006 1
0.0377 0.506 1
0.0601 1 1
0.0204 0.2611 1
0.054 0.6421 1
0.0225 0.7796 1
0.1164 1 1
0.0559 0.6943 1
0.0722 0.4172 1
0.078 0.935 1
0.0951 0.2501 1
0.1155 0.5229 0.5
0.0192 1 1
0.3945 0.5 0.5
0.018 0.8848 0
0.1015 0.2968 1
0.0366 1 1
0.0361 1 0.5
0.0181 0.346 1
0.0223 0.3783 1
0.0188 0.3681 0.5
0.0963 0.6809 1
0.0562 0.7015 1
0.0193 0.3811 1
0.0978 1 1
0.0243 0.9572 0.5
0.1352 1 1
0.1603 0.6455 1
0.1121 1 1
0.0256 0.3131 0.5
0.5233 0.5 0.5
0.035 0.4279 1
0.8419 1 1
0.537 0.3725 1
0.0374 0.4679 0.5
0.0403 0.2504 1
0.0223 0.3166 0.4327
0.0809 0.3044 1
0.0378 1 1
0.5196 0.5777 1
0.0371 0.4077 1
0.1762 1 1
0.0574 0.3867 1
0.0555 0.3424 1
0.0183 0.5254 1
0.1224 1 0.5
0.0392 0.2559 1
0.0552 0.415 1
0.1028 0.4205 1
0.7697 1 1
0.4382 1 1
0.163 1 1
0.1028 0.4205 1
0.019 1 1
0.7233 0.4379 1
0.0588 0.6032 1
0.0933 0.3428 1
0.1332 0.3226 1
0.1242 0.3637 1
0.0594 1 1
0.0223 0.7904 1
0.0203 0.2654 1
0.1762 1 1
0.021 0.3104 1
0.0184 0.4725 1
0.0652 1 1
0.0386 0.5471 1
0.0192 0.2584 1
0.0026 0.3431 1
0.0223 1 1
0.0585 0.8459 1
0.0552 0.6587 1
0.0373 0.5179 1
0.1727 0.9423 1
0.0223 1 0.5
0.5223 1 1
0.155 1 1
0.0587 0.2729 1
0.0401 0.5468 1
0.1286 1 1
0.0376 0.4396 1
0.7654 0.5876 1
0.0216 0.6849 1
0.0185 1 1
0.114063 1 1
0.1927 1 1
0.537 0.3725 1
0.1198 0.8909 1
0.0769 0.3324 1
0.0223 0.5 0.5
0.0223 0.7024 1
0.1481 1 1
0.0762 0.3057 1
0.0179 0.2551 0.5
0.6355 0.4237 1
0.0076 0.3786 1
0.0996 0.3892 1
0.0183 0.7259 1
0.2779 0.2734 1
0.0192 0.4648 0.8105
0.0223 0.2807 1
0.019 0.2548 1
0.062 0.7382 1
0.0365 1 1
0.0448864 0.65261 1
0.0712 1 0.5
0.0629 0.304 1
0.0561 1 1
0.02 0.2853 1
0.116 0.2631 1
0.0548 1 1
0.0365 1 1
0.1516 0.2542 1
0.0748 0.3866 1
0.0199 0.4181 1
0.6494 0.5 0.5
0.0383 1 1
0.0198 1 0.5
0.0206 0.8463 0.5
0.0205 1 1
0.0189 0.9535 1
0.0573 0.2721 1
0.0735 1 0.5
0.0384 0.256 1
0.0361 1 1
0.0363 0.3748 1
0.0768 0.9048 1
0.3285 0.6523 1
0.0187 0.4173 1
0.451 0.5 0.5
0.0375 0.4387 1
0.0179 0.2597 1
0.0179 1 1
0.1696 1 1
0.0175253 0.413958 0.5
0.6888 0.6763 1
0.7283 1 1
0.0378 0.5846 1
0.0774 0.9657 0.5
0.0223 0.2612 1
0.0371 0.445 1
0.0376 1 0.5
0.1015 0.2968 1
0.0185 0.2658 1
0.741 0.9113 1
0.0378 0.5127 1
0.0447 0.5 0.5
0.0192 0.3454 1
0.0764 0.4764 1
0.0585 1 1
0.037 0.7313 0.8113
0.0185 0.2678 1
0.1225 0.4402 1
0.0447 0.5 0.5
0.0223 1 1
0.1268 1 0.5
0.0388 1 1
0.0939 0.5 0.5
0.0389 0.4722 1
0.0223 1 1
0.094 0.9593 1
0.0185 1 1
0.0582 0.8518 1
0.0833 1 0.5
0.1486 1 1
0.1663 1 1
0.0223 0.32 1
0.0374 0.4083 0.5
0.1028 0.4205 1
0.0368 0.2631 0.336
0.039 0.2676 1
0.4413 0.2748 1
0.0604 0.834 0.5
0.1077 0.4235 1
0.093 0.5055 1
0.0223 0.6805 1
0.0184 0.5592 1
0.0395 0.494 1
0.0567 0.6925 1
0.3187 0.2951 1
0.0934 0.285 1
0.3131 1 1
0.0223 0.9163 1
0.7671 1 1
0.0374 0.4624 1
0.0597 0.3568 1
0.2293 1 1
0.0195 0.2823 1
0.018 1 1
0.1719 0.4181 1
0.1164 0.5987 1
0.1645 0.9102 1
0.0366 0.3638 0.5
0.3224 0.3427 1
0.2029 0.5748 1
0.0361 1 0.5
0.0547 0.7677 1
0.0155 0.2936 1
0.04 0.5571 1
0.0206 1 0.5
0.0462 0.2508 1
0.0223 1 1
0.0203 0.2836 1
0.0339 0.4379 1
0.0758 0.5412 1
0.0548 1 1
0.0548 1 1
0.0179 0.7619 1
0.6412 1 1
0.0189 0.3678 1
0.058 0.585 1
0.1879 1 1
0.3419 0.5 0.5
0.036 0.3507 0.5559
0.0364 0.6653 0.5
0.0223 0.2612 1
0.0541 0.3328 1
0.042 1 1
1.5976 1 1
0.0549 0.3866 1
0.0541 0.3328 1
0.0179 0.4335 1
0.037 1 1
0.0223 1 1
0.2011 1 1
0.0187 0.2771 0.5422
0.0223 0.7666 0.7645
0.0223 0.5 0.5
0.0592 1 1
0.0447 0.5 0.5
0.2029 0.5748 1
0.0183 0.3362 1
0.0949 0.3843 1
0.0378 0.5283 1
0.7007 1 1
0.0419 0.5528 1
0.1634 0.5584 1
0.0223 1 0.5
0.0859 0.3048 1
0.2082 1 1
0.055 0.6136 0.8934
0.1174 0.5843 0.5
0.0406 0.4254 1
0.039 0.8804 1
0.02 0.381 1
0.0361 0.4247 1
0.0583 0.3517 1
0.0179 0.7046 1
0.0378 1 1
0.7141 0.7479 1
0.3696 1 1
0.6105 1 1
0.1765 0.3343 0.8054
0.7305 1 1
0.0371 0.4429 1
0.3696 1 1
0.1783 0.5423 1
0.0371 0.4663 0.5
0.0223 0.9944 0.5
0.0182 0.3876 1
0.0223 0.5 0.5
0.056 1 1
0.0181 0.7624 1
0.0223 0.6142 1
0.0363 0.3834 1
0.0205061 1 0.5
0.0379 0.5315 1
0.0607 0.3355 0.5
0.039 0.7915 1
0.0751 0.2704 1
0.0179 0.5396 1
0.0903 0.3777 1
1.1306 1 1
0.234 0.2887 1
0.0383 0.4079 1
0.0186 0.5291 1
0.0185 0.3645 1
0.0595 0.7298 1
0.0162 0.4542 0.5
0.1032 1 0.5
0.0146 0.7186 1
0.883 1 1
0.0573 0.714 1
0.0438 0.7174 1
0.0807 1 1
0.0196 0.2885 0.5
0.7288 1 1
0.0421 1 0.5
0.0189 0.3169 1
0.058 0.6464 0.6464
0.0182 0.3983 1
0.0771 0.9614 1
0.0187 0.2518 1
0.0225 0.8948 1
0.0223 0.7755 1
0.0447 0.5 0.5
0.0197 0.5548 1
0.0385 0.331 1
0.1502 0.7066 1
0.0183 0.7152 1
0.0597 1 1
0.1562 0.6874 1
0.883 1 1
0.0223 0.4304 0.5
0.0223 0.5 0.5
0.0921 1 1
0.7737 1 1
0.0181 0.2742 1
0.0183 0.493 1
0.0186 0.7657 1
0.537 0.3725 1
0.0223 0.9992 1
0.1329 0.8197 1
0.0545 1 1
0.1387 0.4949 1
0.0388 1 1
0.0384 0.547 1
0.0902 1 1
0.0201 0.2637 1
0.0239 0.2794 0.8718
0.0223 0.2666 1
0.0179 0.3911 1
0.0193 0.3503 1
0.0537 0.3335 1
0.5335 1 1
0.0638 0.3343 1
0.0182 0.8389 1
0.0461 0.5 0.5
0.0198 0.2909 1
0.0369 0.4629 1
0.0597 1 1
0.1562 0.6874 1
0.0377 1 1
0.0179 1 1
0.0762 0.2522 1
0.5204 0.5 0.5
0.0596 0.3036 1
0.6382 0.2922 1
0.0583 0.2752 1
0.0614 1 1
0.0753 0.5687 1
0.0418 0.2832 0.5413
0.0725 0.8674 1
0.0369 1 1
0.0223 0.2956 1
0.0374 0.7589 1
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0.1715 1 1
0.1836 0.7487 1
0.1404 0.4046 1
0.0182 0.5358 1
0.0784 0.9443 1
0.0584 0.5 0.5
0.0389 0.5307 1
0.0364 1 1
0.0395 0.2563 1
0.1906 1 1
0.0783 0.2953 1
0.099 1 1
0.0221 1 1
0.0182 1 0.5
0.3515 0.2965 1
0.1603 0.6455 1
0.0223 1 0.5
0.5618 1 1
0.0368 0.2631 0.336
0.0376 1 1
0.121 0.5847 1
0.0367 1 1
0.0192 1 0.5
0.0383 0.5 0.5
0.0587 0.7244 1
0.0183 0.2937 0.5474
0.482 1 1
0.1562 0.6874 1
0.0192 0.2565 0.9106
0.1372 1 0.5
0.0194 0.7638 1
0.0181 0.5573 1
0.1154 0.7179 1
0.1481 1 1
0.3074 1 1
0.1182 0.4289 1
0.0223 0.9701 1
0.0578 0.4046 1
0.077 1 1
0.0751 0.4383 1
0.074 0.8346 1
0.0181 1 1
0.0179235 1 0.5
0.0184 1 0.5
0.0422 0.3229 1
0.0162 0.4542 0.5
0.1729 1 1
0.0592 0.3565 1
0.0772 0.3951 1
0.0742 0.2882 1
0.695 1 1
0.0188 0.5627 1
0.0567 0.3835 1
0.1154 0.5543 1
0.537 0.3725 1
0.1294 0.5357 1
0.1837 1 1
0.0447 0.5 0.5
0.1107 1 1
0.0434 0.287 1
0.6406 1 1
0.1347 0.805 1
0.0179 0.3493 1
0.0367 0.4954 1
0.0181 1 1
0.1645 0.9102 1
0.0382 0.3787 1
0.0223 0.5314 1
0.0219 0.7499 0.5
0.154 1 1
0.2018 1 1
0.0573 0.714 1
0.0447 0.2605 0.5
0.0181 0.4483 1
0.0447 0.5 0.5
0.056 0.7111 1
0.6011 0.5 0.5
0.1332 0.3226 1
0.0376 1 1
0.0223 0.3434 0.5
0.0433 0.5048 0.6957
0.7141 0.7479 1
0.1032 1 0.5
0.0564 0.4025 1
0.0223 0.326 1
0.0223 0.7129 1
0.0223 0.2632 1
0.019 1 1
0.036 0.3597 1
0.0544 0.6686 1
0.0364 1 1
0.0559 1 1
0.1036 1 1
0.0745 0.27 1
0.0378 1 1
0.3866 1 1
0.018 0.4345 1
0.0199 1 0.5
0.0185 0.5558 1
0.3285 0.6523 1
0.0185 0.2958 0.5
0.0745 1 1
0.1751 0.6934 1
0.0952 0.7696 1
0.7141 0.7479 1
0.236 0.3351 0.3649
0.0447 0.5263 1
0.4602 1 1
0.0638 0.3343 1
0.0182 1 1
0.0402 1 1
0.0189 0.4429 1
0.0757 0.9119 1
0.0226 0.2807 0.8735
0.0686 0.3042 1
0.1727 0.9423 1
0.022 0.2537 0.4286
0.7141 0.7479 1
0.6497 1 1
0.0952 0.7696 1
0.883 1 1
0.0223 0.3696 0.3668
0.119 1 1
0.0358 1 1
0.039667 0.330216 1
0.08 1 1
0.0359 0.504 1
0.0447 0.5 0.5
0.0185 0.8616 0.5
0.042 0.8175 0.814
0.0561 1 1
0.0554 1 0.5
0.0447 0.5 0.5
0.0973 0.9318 1
0.0574 0.4181 1
0.1548 1 1
0.1368 0.8505 1
0.0182 0.5792 1
0.054 0.3918 1
0.0769 0.3011 1
0.0216 0.2587 1
0.0181 1 1
0.0377 0.2505 1
0.043 0.2583 1
0.0223 0.5 0.5
0.0223 0.2737 1
0.6714 0.5 0.5
0.0588 0.2751 1
0.7141 0.7479 1
0.0201 0.2897 1
0.0878 0.3161 1
0.0399 0.547 1
0.0223 1 0.5
0.0396 0.4681 1
0.0362 0.2512 1
0.0363 0.4046 0.5
0.0815 0.308 1
0.0177 0.4295 1
0.0367 0.7395 1
0.0578 0.5 0.5
0.0189 0.8016 1
0.018 0.5 0.5
0.5602 0.3323 1
0.0923 0.3661 1
0.0192 0.6039 1
0.1765 0.3343 0.8054
0.0223 0.5 0.5
0.0376 0.4802 1
0.0795 0.3012 1
0.1313 0.5 0.5
0.0563 1 1
0.0377 0.4724 1
0.0184 0.9309 1
0.0175253 0.413958 0.5
0.0365 1 1
0.6312 1 1
0.0751 0.2704 1
0.0223 0.5 0.5
0.0189 0.2537 1
0.5968 1 1
0.608 1 1
0.0389 0.4722 1
0.0376 1 1
0.0223 1 1
0.0182 0.5237 0.9883
0.6808 1 1
0.1557 1 1
0.0569 1 1
0.1536 1 1
0.0111 0.4402 1
0.0191 0.647 1
0.0351 0.2571 1
0.6764 1 1
0.207 1 1
0.056 0.7111 1
0.537 0.3725 1
0.0223 0.2653 0
0.0568 0.69 1
0.0552 0.598 0
0.121 0.5847 1
0.3148 1 1
0.0395 0.5 0.5
0.1016 0.5 0.5
0.0395 0.8105 0.8105
0.0359 0.7625 1
0.0192 0.5945 1
0.062 0.7382 1
0.0934 0.5808 1
0.0378 1 1
0.208 0.3555 1
0.0223 1 1
0.0385 1 1
0.1015 0.2968 1
0.1694 1 0.5
0.1726 0.9368 1
0.0821 0.6389 1
0.0785 0.4748 1
0.6355 0.4237 1
0.1502 1 1
0.883 1 1
0.036 1 1
0.0365 0.4454 1
0.1494 1 1
0.062 1 1
0.0233 0.5335 1
0.0122 0.3242 1
0.0179 0.489 0.5
0.1151 0.8506 1
0.0191 0.8046 1
0.0745 0.27 1
0.0551 0.2598 1
0.0875 0.3041 1
0.0184 0.5143 1
0.0183 0.489 0.5
0.0369 0.445 0.5188
0.0223 0.6568 1
0.0638 0.3343 1
0.0223 0.5 0.5
0.2129 1 1
0.0219066 0.5 0.5
0.1562 0.6874 1
0.5907 0.5 0.5
0.2075 1 1
0.0186 0.2803 1
0.0751 0.2704 1
0.0223 1 1
0.0184 0.5143 1
0.3125 1 1
0.0523 1 0.5
0.0395 0.2563 1
0.055 0.8156 1
0.0181 0.2742 1
0.0567 1 1
0.018 0.6478 1
0.0996 0.3892 1
0.1077 0.4235 1
0.0351 0.2571 1
0.0182 0.4406 1
0.537 0.3725 1
0.0367 0.7346 1
0.0638 0.3343 1
0.741 0.9113 1
0.754 1 1
0.0573 0.714 1
0.0223 0.6787 0.5
0.1085 1 1
0.0223 0.9515 1
0.0191 0.5336 1
0.018 0.371 0.5
0.1533 0.552 1
0.0204 0.3836 0.5
0.0967 1 1
0.1935 1 0.5
0.0214 0.6799 1
0.0223 0.3038 0.5
0.0223 0.9122 1
0.0409 0.2759 1
0.0382844 1 0.5
0.4063 1 1
0.0191 1 1
0.0582 0.3999 0.3996
0.0188 0.5 0.5
0.0374 0.4159 1
0.169 0.279 1
0.0378 1 1
0.037 0.4173 1
0.0386 0.2752 1
0.0205 0.7028 0.5
0.0188 0.5526 1
0.1148 0.8628 1
0.0559 1 1
0.0181 1 0.5
0.0842 0.3041 1
0.0401 0.2759 1
0.0219066 0.5 0.5
0.1811 0.3134 1
0.0428 0.6598 1
0.0194 0.2639 1
0.0637 1 0.5
0.0447 0.5 0.5
0.0223 0.5 0.5
0.0197 0.5291 1
0.0771 0.9614 1
0.0355414 0.5 0.5
0.7697 1 1
0.0367 1 0.5
0.0223 1 0.5
0.481 1 1
0.0367 0.7346 1
0.0378518 0.330803 0.738266
0.777 0.5861 1
0.0223 0.2536 0.5
0.3157 0.4249 1
0.155 1 1
0.0219066 1 0.5
0.3132 1 1
0.0557 0.7032 1
0.1192 0.5258 1
0.0366 1 0.5
0.0395 0.2674 1
0.0185 0.3705 1
0.0821 0.4439 1
0.0956 1 1
0.0738 0.8598 1
0.6312 1 1
0.0223 0.8394 0.5
0.1329 0.5403 1
0.0223 0.5 0.5
0.0223 1 1
0.0182 0.448 1
0.0189 0.5153 0.5
0.0179 0.4854 1
0.0376 0.2559 1
0.0198 0.8315 1
0.0559 0.3111 1
0.0181 0.3902 1
0.0223 0.5 0.5
0.7131 1 1
0.0391 0.5 0.5
0.0652 1 1
0.0447 0.5 0.5
0.0225 0.2576 1
0.0187 0.2771 0.5422
0.0952 0.5952 1
0.1119 0.7166 1
0.0223 0.7102 1
0.5371 0.5 0.5
0.1765 0.3343 0.8054
0.0223 1 0.5
0.0184 0.2827 1
0.0923 1 1
0.0413 1 0.5
0.0765 0.2922 1
0.0374 0.368 1
0.0447 0.5 0.5
0.0362 0.4361 1
0.3437 1 1
0.0223 0.4319 1
0.0179 0.3038 1
0.0192 0.29 0.312
0.0194 0.2779 1
0.0361 0.4347 1
0.537 0.3725 1
0.0447 0.5 0.5
0.1227 0.4349 1
0.0361 0.5 0.5
0.0181 1 0.5
0.0183 0.2553 0.4815
0.0179 0.3636 1
0.0571 0.3334 1
0.6883 1 1
0.0189 0.6748 1
0.0386 0.4143 0
0.0223 0.7524 1
0.0223 0.3654 0.6879
0.7141 0.7479 1
0.0447 0.5 0.5
0.7756 1 1
0.0753 0.5687 1
0.0616 1 1
0.0743 1 0.5
0.0369 1 1
0.7333 0.5 0.5
0.3131 1 1
0.0182 0.256 1
0.0223 1 1
0.0223 0.5 0.5
0.0223 0.3478 0.5
0.0447 0.5 0.5
0.0366 0.4362 1
0.0223 0.3048 0
0.0989 0.599 1
0.0162 0.4542 0.5
0.0148 0.7372 0.5
0.0755 1 1
0.0402 1 0.5
0.219 1 1
0.15 0.558 1
0.018 1 1
0.0223 1 0.5
0.0179 1 1
0.0388 0.3107 1
0.1364 0.8694 0.5
0.6556 0.5 0.5
0.0201 0.3209 1
0.0223 0.5 0.5
0.0221 1 0.5
0.2779 0.2734 1
0.0189 0.5857 0.5
0.0762 0.2522 1
0.0223 0.8452 1
0.0189 0.2614 1
0.0398 0.8311 0.5
0.0385 0.331 1
0.0183 1 0.5
0.7141 0.7479 1
0.1143 0.5258 0.5
0.0223 0.2855 1
0.058 1 1
0.1491 0.7059 1
0.0183 0.268 1
0.0223 0.7184 1
0.7697 1 1
0.0569 0.3447 1
0.1542 1 1
0.0223 1 0.5
0.0216 0.2587 1
0.018 0.2565 1
0.0374 0.368 1
0.0362 0.4361 1
0.0371 0.3686 1
0.1484 0.9963 1
0.1344 1 0.5
0.3945 0.5 0.5
0.0365 0.5379 1
0.02 0.2627 1
0.0933 0.3428 1
0.0364 0.6653 0.5
0.0773 0.3687 1
0.0559 1 1
0.1362 1 1
0.0192 0.266 1
0.0182 1 0.5
0.0409 0.2758 1
0.039 0.2676 1
0.63 0.5 0.5
0.0807 1 1
0.0375 0.5473 1
0.0427 0.5484 1
0.0532 0.4502 1
0.0182 1 1
0.0347 0.8472 1
0.0182 0.7497 0
0.2064 1 1
0.0368 1 1
0.0368 0.3898 0.5
0.0179 0.9952 0.5
0.0371 0.4429 1
0.0197 0.8675 0.5
0.0188 0.3552 1
0.1585 0.6871 1
0.2018 1 1
0.0367 0.4954 1
0.0625 0.2636 1
0.0583 0.2751 1
0.0183 0.5873 0.5
0.0216 0.2587 1
0.0182 0.8885 1
0.0559 1 1
0.0359 1 1
0.1375 0.5 0.5
0.0371 0.2625 1
0.741 0.9113 1
0.0367 1 1
0.1588 0.5371 1
0.7737 1 1
0.0446 0.6334 1
0.0196 1 1
0.754 1 1
0.1718 1 1
0.0368 1 1
0.0223 1 1
0.0557 1 1
0.1502 0.7066 1
0.0727 0.2839 1
0.0592 1 1
0.0606 1 1
0.3285 0.6523 1
0.0447 0.5 0.5
0.0179 1 1
0.0213 0.5 0.5
0.2075 1 1
0.3285 0.6523 1
0.0375 0.7687 1
0.0994 0.5 0.5
0.537 0.3725 1
0.018 0.5296 1
0.0555 0.3424 1
0.0447 0.5 0.5
0.2023 1 1
0.0223 0.4469 1
0.1994 1 1
0.0223 1 1
0.3384 0.5032 1
0.883 1 1
0.0447 1 0.5
0.1488 0.5248 1
0.0179 0.9622 1
0.0223 0.7767 0.5
0.0397 0.2761 1
0.0746 0.4426 1
0.0378 1 1
0.0384 0.2701 1
0.0188 1 0.5
0.0182 0.5855 1
0.0184 1 0.5
0.1142 0.6476 1
0.2115 1 1
0.0438 0.7174 1
0.0368 0.7723 1
0.0182 0.3337 1
0.1024 0.7481 1
0.0363 0.9749 1
0.1562 0.6874 1
0.1193 0.4227 1
0.0185 0.5493 1
0.065 0.7615 1
0.0187 0.7614 0
0.0193 0.3091 0.5
0.0366 0.5 0.5
0.0223 0.4668 1
0.0422 0.3229 1
0.0552 0.4619 1
0.1207 0.2859 1
0.0223 0.4192 1
0.0187448 1 1
0.0183 0.2944 1
0.6527 1 1
0.1272 0.8011 1
0.0371 0.434 1
0.17 1 1
0.0223 0.5 0.5
0.0607 0.3355 0.5
0.0133 0.8786 1
0.0189 0.273 1
0.0189 0.4429 1
0.0183 0.732 1
0.018 0.6939 1
0.0366 0.2613 1
0.2293 1 1
0.1111 1 1
0.074 1 1
0.0223 1 0.5
0.0189 1 0.5
0.0223 0.5 0.5
0.3187 0.2951 1
0.0182 0.3337 1
0.1751 0.6934 1
0.3866 1 1
0.022 0.7516 1
0.7572 1 1
0.0382 1 1
0.3285 0.6523 1
0.0759 0.939 1
0.1173 1 1
0.0396 0.8094 1
0.039 0.2676 1
0.7732 1 1
0.777 0.5861 1
0.0181 0.425 1
0.0184109 0.324553 0
0.0415 0.6742 1
0.0223 0.3215 1
0.0407 1 1
0.0364 0.426 1
0.0368 0.3689 1
0.7141 0.7479 1
0.0184 0.8078 0.5
0.0223 1 1
0.1143 0.3169 0.5
0.0855 1 1
0.5223 1 1
0.0223 0.2517 1
0.0239 0.2794 0.8718
0.0556 0.3348 1
0.6412 1 1
0.0188 1 0.5
0.036 1 1
0.0382 0.3787 1
0.0179 0.7992 1
0.0179 0.2736 1
0.0223 1 0.5
0.1765 0.3343 0.8054
0.0182554 1 1
0.0364 0.5191 1
0.0548 0.6564 1
0.0414 0.5153 1
0.0565 0.8036 1
0.0384 0.5596 1
0.0188 0.5726 1
0.0381 0.68 1
0.0593 1 1
0.0364 0.6653 0.5
0.0403 0.2764 1
0.0606 1 1
0.0779 0.9338 1
0.1713 1 1
0.1143 0.8327 1
0.0198 1 1
0.1124 1 1
0.7445 1 1
0.0181 1 0.5
0.0223 1 0.5
0.0181 0.382 1
0.0183 0.3536 0.5
0.0771 0.3105 1
0.1854 1 1
0.116 0.2631 1
0.0834 1 1
0.111 0.5189 1
0.0932 1 1
0.0378 0.3107 1
0.1108 0.3456 1
0.7315 1 1
0.0182 0.5392 1
0.0223 0.3108 1
0.0361 1 1
0.039 0.2676 1
0.018 0.2986 1

Assayability

Assay information

  • Inhibition of Plasmodium falciparum ENR enzymatic activity ChEMBL
  • Inhibition of Plasmodium falciparum ENR enzymatic activity
  • Inhibition of PfENR enzymatic activity ChEMBL
  • Inhibition of PfENR enzymatic activity
  • Inhibition of FabI ChEMBL
  • Inhibition of FabI
  • Inhibition of FabI at 100 uM ChEMBL
  • Inhibition of FabI at 100 uM
  • Inhibition of Plasmodium falciparum ENR in presence of ECG ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of ECG
  • Inhibition of Plasmodium falciparum ENR ChEMBL
  • Inhibition of Plasmodium falciparum ENR
  • Inhibition of Plasmodium falciparum ENR using NADH substrate ChEMBL
  • Inhibition of Plasmodium falciparum ENR using NADH substrate
  • Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate ChEMBL
  • Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate
  • Inhibition of Plasmodium falciparum ENR in presence of triclosan ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of triclosan
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGCG ChEMBL
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGCG
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of ECG ChEMBL
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of ECG
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGC ChEMBL
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGC
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of quercetin ChEMBL
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of quercetin
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of butein ChEMBL
  • Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of butein
  • Inhibition of Plasmodium falciparum ENR in presence of EGC ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of EGC
  • Inhibition of Plasmodium falciparum ENR in presence of EGCG ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of EGCG
  • Inhibition of Plasmodium falciparum ENR in presence of EGCG by dilution assay ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of EGCG by dilution assay
  • Inhibition of Plasmodium falciparum ENR in presence of EGC by dilution assay ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of EGC by dilution assay
  • Inhibition of Plasmodium falciparum ENR in presence of ECG by dilution assay ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of ECG by dilution assay
  • Inhibition of Plasmodium falciparum ENR in presence of quercetin by dilution assay ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of quercetin by dilution assay
  • Inhibition of Plasmodium falciparum ENR in presence of butein by dilution assay ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of butein by dilution assay
  • Inhibition of Plasmodium falciparum ENR in presence of quercetin ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of quercetin
  • Inhibition of Plasmodium falciparum ENR in presence of butein ChEMBL
  • Inhibition of Plasmodium falciparum ENR in presence of butein
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH ChEMBL
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA ChEMBL
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells ChEMBL
  • Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells
  • Inhibition of Plasmodium falciparum FabI ChEMBL
  • Inhibition of Plasmodium falciparum FabI
  • Inhibition of Plasmodium falciparum FabI in presence of variable crotonyl-coA level ChEMBL
  • Inhibition of Plasmodium falciparum FabI in presence of variable crotonyl-coA level
  • Inhibition of Plasmodium falciparum FabI in presence of variable NADH levels ChEMBL
  • Inhibition of Plasmodium falciparum FabI in presence of variable NADH levels
  • Inhibition of Plasmodium falciparum ENR ChEMBL
  • Inhibition of Plasmodium falciparum ENR
  • ChEMBL
  • Inhibition of Plasmodium falciparum recombinant FabI
  • ChEMBL
  • Inhibition of Plasmodium falciparum FabI assessed as saturated acyl-acyl carrier protein level at 5 uM by MALDI-TOF mass spectrometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase
  • ChEMBL
  • Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase expressed in Escherichia coli BL21(DE3) by spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum FabI
  • ChEMBL
  • Inhibition of Plasmodium falciparum FabI by spectrophotometric analysis
  • ChEMBL
  • Non-competitive inhibition of Plasmodium falciparum FabI using crotonyl-CoA as substrate by Michaelis-Menten steady state analysis
  • ChEMBL
  • Non-competitive inhibition of Plasmodium falciparum FabI using NADH as cofactor by Michaelis-Menten steady state analysis
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.05 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.075 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.15 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.1 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.025 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.25 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
  • ChEMBL
  • Inhibition of Plasmodium falciparum enoyl-ACP reductase assessed as oxidation of NADH to NAD+ after 10 mins by spectrophotometric analysis
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 2 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    PF3D7_0615100 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Plasmodium falciparum ( 4 )

Bibliographic References

21 literature references were collected for this gene.

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Gene identifier PF3D7_0615100 (Plasmodium falciparum), enoyl-acyl carrier reductase
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