Detailed view for LmxM.19.0995

Basic information

TDR Targets ID: 450487
Leishmania mexicana, 4-coumarate:coa ligase-like protein

Source Database / ID: 

pI: 8.3512 | Length (AA): 633 | MW (Da): 68630 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00501   AMP-binding enzyme
PF13193   AMP-binding enzyme C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 630 5jrh (A) 20 634 19.00 0 1 1.12087 0.25
80 617 5bsr (A) 11 535 31.00 0 1 1.21912 -0.27
80 617 3ni2 (A) 8 532 32.00 0 1 1.21412 -0.32
99 514 4w8o (A) 20 427 23.00 0 1 0.955388 -0.26
523 616 4u5y (D) 529 617 22.00 0 0.93 0.441299 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_126609)

Species Accession Gene Product
Arabidopsis thaliana AT1G65060   4-coumarate--CoA ligase 3
Arabidopsis thaliana AT3G48990   4-coumarate--CoA ligase-like 10
Arabidopsis thaliana AT1G20510   OPC-8:0 CoA ligase1
Arabidopsis thaliana AT1G30520   2-succinylbenzoate--CoA ligase
Arabidopsis thaliana AT3G21230   4-coumarate--CoA ligase 5
Arabidopsis thaliana AT1G20490   4-coumarate--CoA ligase-like 3
Arabidopsis thaliana AT1G20480   AMP-dependent synthetase and ligase family protein
Arabidopsis thaliana AT3G21240   4-coumarate--CoA ligase 2
Arabidopsis thaliana AT1G51680   4-coumarate--CoA ligase 1
Arabidopsis thaliana AT1G20500   4-coumarate--CoA ligase-like 4
Arabidopsis thaliana AT5G38120   4-coumarate--CoA ligase-like 8
Arabidopsis thaliana AT4G05160   4-coumarate--CoA ligase-like 7
Brugia malayi Bm1_51305   AMP-binding enzyme family protein
Brugia malayi Bm1_29700   AMP-binding enzyme family protein
Brugia malayi Bm1_03830   AMP-binding enzyme family protein
Caenorhabditis elegans CELE_F46E10.1   Protein ACS-1, isoform A
Caenorhabditis elegans CELE_F25C8.4   Protein ACS-12
Caenorhabditis elegans CELE_F11A3.1   Protein ACS-14
Caenorhabditis elegans CELE_C01G6.7   Protein ACS-7
Chlamydia trachomatis CT_776   acylglycerophosphoethanolamine acyltransferase
Dictyostelium discoideum DDB_G0284745   4-coumarate-CoA ligase
Dictyostelium discoideum DDB_G0279561   AMP-dependent synthetase and ligase domain-containing protein
Dictyostelium discoideum DDB_G0284743   4-coumarate-CoA ligase
Dictyostelium discoideum DDB_G0284831   4-coumarate-CoA ligase
Drosophila melanogaster Dmel_CG9009   pudgy
Drosophila melanogaster Dmel_CG12512   CG12512 gene product from transcript CG12512-RA
Drosophila melanogaster Dmel_CG6178   CG6178 gene product from transcript CG6178-RA
Escherichia coli b1701   short chain acyl-CoA synthetase, anaerobic
Escherichia coli b1805   acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)
Escherichia coli b0037   putative crotonobetaine/carnitine-CoA ligase
Entamoeba histolytica EHI_010560   acyl-CoA synthetase, putative
Entamoeba histolytica EHI_131880   acyl-coA synthetase, putative
Entamoeba histolytica EHI_135740   acyl-CoA synthetase, putative
Homo sapiens ENSG00000167107   acyl-CoA synthetase family member 2
Leishmania braziliensis LbrM.19.1280   4-coumarate:coa ligase-like protein
Leishmania donovani LdBPK_190940.1   4-coumarate:coa ligase-like protein
Leishmania donovani LdBPK_190970.1   4-coumarate:coa ligase-like protein
Leishmania infantum LinJ.19.0960   4-coumarate:coa ligase-like protein
Leishmania infantum LinJ.19.0970   4-coumarate:coa ligase-like protein
Leishmania infantum LinJ.19.0940   4-coumarate:coa ligase-like protein
Leishmania infantum LinJ.19.0950   4-coumarate:coa ligase-like protein
Leishmania major LmjF.19.1005   4-coumarate:coa ligase-like protein
Leishmania major LmjF.19.0995   4-coumarate:coa ligase-like protein
Leishmania major LmjF.19.0985   4-coumarate:coa ligase-like protein
Leishmania mexicana LmxM.19.0985   4-coumarate:coa ligase-like protein
Leishmania mexicana LmxM.19.1005   4-coumarate:coa ligase-like protein
Leishmania mexicana LmxM.19.0995   4-coumarate:coa ligase-like protein
Loa Loa (eye worm) LOAG_15996   hypothetical protein
Loa Loa (eye worm) LOAG_07755   hypothetical protein
Loa Loa (eye worm) LOAG_15223   hypothetical protein
Loa Loa (eye worm) LOAG_13706   hypothetical protein
Loa Loa (eye worm) LOAG_00184   hypothetical protein
Loa Loa (eye worm) LOAG_04571   hypothetical protein
Loa Loa (eye worm) LOAG_04570   hypothetical protein
Loa Loa (eye worm) LOAG_14723   hypothetical protein
Mus musculus ENSMUSG00000076435   acyl-CoA synthetase family member 2
Mycobacterium tuberculosis Rv0119   Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium tuberculosis Rv3561   Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium tuberculosis Rv2505c   Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium tuberculosis Rv0166   Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium tuberculosis Rv3089   Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)
Mycobacterium tuberculosis Rv0270   Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium tuberculosis Rv0404   Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Mycobacterium ulcerans MUL_3844   fatty-acid-CoA ligase
Mycobacterium ulcerans MUL_1191   acyl-CoA synthetase
Mycobacterium ulcerans MUL_3145   hypothetical protein
Mycobacterium ulcerans MUL_3890   long-chain fatty-acid CoA ligase
Mycobacterium ulcerans MUL_0362   acyl-CoA synthetase
Mycobacterium ulcerans MUL_4803   acyl-CoA synthetase
Mycobacterium ulcerans MUL_4126   long-chain-fatty-acid--CoA ligase
Mycobacterium ulcerans MUL_1115   long-chain-fatty-acid-CoA ligase
Mycobacterium ulcerans MUL_3431   fatty-acid-CoA ligase
Oryza sativa 4341718   Os06g0656500
Oryza sativa 4345054   Os08g0245200
Oryza sativa 4330407   Os02g0697400
Oryza sativa 4331650   Os03g0152400
Oryza sativa 4337447   Os04g0683700
Oryza sativa 4345717   Os08g0448000
Oryza sativa 4328485   Os02g0177600
Oryza sativa 4331515   Os03g0132000
Oryza sativa 4344589   Os08g0130400
Onchocerca volvulus OVOC11935  
Plasmodium berghei PBANKA_1118700   acyl-CoA synthetase, putative
Plasmodium falciparum PF3D7_0619500   acyl-CoA synthetase
Plasmodium knowlesi PKNH_1130800   acyl-CoA synthetase, putative
Plasmodium vivax PVX_114100   acyl-CoA synthetase, putative
Plasmodium yoelii PY05696   peroxisomal-coenzyme a synthetase
Saccharomyces cerevisiae YBR222C   Pcs60p
Schmidtea mediterranea mk4.042846.01  
Schmidtea mediterranea mk4.034971.02  
Schmidtea mediterranea mk4.000024.07  
Schmidtea mediterranea mk4.000024.09  


LmxM.19.0995 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3142 Mycobacterium tuberculosis non-essential nmpdr
mtu273 Mycobacterium tuberculosis non-essential nmpdr
mtu407 Mycobacterium tuberculosis essential nmpdr
b0037 Escherichia coli non-essential goodall
b1701 Escherichia coli non-essential goodall
b1805 Escherichia coli non-essential goodall
CELE_F46E10.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_F46E10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F46E10.1 Caenorhabditis elegans larval arrest wormbase
CELE_F46E10.1 Caenorhabditis elegans larval lethal wormbase
CELE_F46E10.1 Caenorhabditis elegans slow growth wormbase
CELE_F46E10.1 Caenorhabditis elegans sterile wormbase
PBANKA_1118700 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Luciola lateralis Luciferase Compounds References
Photuris pennsylvanica Luciferase Compounds References
Photinus pyralis Luciferin 4-monooxygenase Compounds References
Photuris pennsylvanica Luciferin 4-monooxygenase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 580 aa 22.8% 570 aa Compounds References
Yersinia pestis AMP-binding enzyme family protein 525 aa 23.8% 541 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmxM.19.0995 (Leishmania mexicana), 4-coumarate:coa ligase-like protein
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