pI: 4.8982 |
Length (AA): 516 |
MW (Da): 59192 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
179 | 250 | 2avp (A) | 1 | 68 | 12.00 | 0.0000001 | 0.06 | 0.25 | -0.66 |
2 | 395 | 1dce (A) | 2 | 249 | 35.00 | 0 | 0.99 | 0.469166 | 1.37 |
24 | 86 | 5cs0 (A) | 803 | 866 | 38.00 | 0.84 | 0.17 | 0.443693 | 0.29 |
436 | 498 | 5fzs (A) | 21 | 83 | 10.00 | 0.026 | 0.01 | 0.311093 | -1.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128238)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G41820 | RAB geranylgeranyl transferase alpha subunit 2 |
Arabidopsis thaliana | AT4G24490 | RAB geranylgeranyl transferase alpha subunit 1 |
Babesia bovis | BBOV_III009610 | protein prenyltransferase alpha subunit repeat domain containing protein |
Brugia malayi | Bm1_22825 | Protein prenyltransferase alpha subunit repeat containing protein |
Candida albicans | CaO19.8641 | C terminus of Rab-protein geranylgeranyl transferase type II alpha subunit |
Candida albicans | CaO19.1039 | C terminus of Rab-protein geranylgeranyl transferase type II alpha subunit |
Caenorhabditis elegans | CELE_M57.2 | Protein M57.2 |
Cryptosporidium hominis | Chro.70590 | Rab geranylgeranyltransferase, alpha subunit isoform a |
Cryptosporidium parvum | cgd7_5300 | Rab geranylgeranyltransferase, alpha subunit |
Dictyostelium discoideum | DDB_G0269570 | Rab geranylgeranyltransferase alpha subunit |
Drosophila melanogaster | Dmel_CG12007 | CG12007 gene product from transcript CG12007-RA |
Echinococcus granulosus | EgrG_000832400 | geranylgeranyl transferase type 2 subunit alpha |
Entamoeba histolytica | EHI_023180 | Rab geranylgeranyltransferase alpha subunit, putative |
Echinococcus multilocularis | EmuJ_000832400 | geranylgeranyl transferase type 2 subunit alpha |
Giardia lamblia | GL50803_16675 | Rab geranylgeranyltransferase |
Homo sapiens | ENSG00000100949 | Rab geranylgeranyltransferase, alpha subunit |
Leishmania braziliensis | LbrM.33.1220 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_331080.1 | Protein prenyltransferase alpha subunit repeat, putative |
Leishmania infantum | LinJ.33.1080 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.32.1030 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05798 | prenyltransferase alpha subunit repeat containing protein |
Mus musculus | ENSMUSG00000040472 | Rab geranylgeranyl transferase, a subunit |
Oryza sativa | 4341838 | Os06g0677500 |
Onchocerca volvulus | OVOC3245 |
|
Plasmodium berghei | PBANKA_1306400 | geranylgeranyl transferase type-2 subunit alpha, putative |
Plasmodium falciparum | PF3D7_1442500 | geranylgeranyl transferase type-2 subunit alpha, putative |
Plasmodium knowlesi | PKNH_1239800 | geranylgeranyl transferase type-2 subunit alpha, putative |
Plasmodium vivax | PVX_118365 | protein prenyltransferase alpha subunit, putative |
Plasmodium yoelii | PY02453 | hypothetical protein |
Saccharomyces cerevisiae | YJL031C | Bet4p |
Schistosoma japonicum | Sjp_0312680 | ko:K03511 DNA polymerase kappa subunit, putative |
Schistosoma japonicum | Sjp_0056380 | ko:K05956 Rab geranylgeranyltransferase, alpha subunit [EC:2.5.1.60], putative |
Schistosoma mansoni | Smp_146090 | rab geranylgeranyl transferase alpha subunit |
Schmidtea mediterranea | mk4.002333.04 | Geranylgeranyl transferase type-2 subunit alpha |
Schmidtea mediterranea | mk4.015762.00 | Geranylgeranyl transferase type-2 subunit alpha |
Trypanosoma brucei gambiense | Tbg972.10.14030 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.11640 | Protein prenyltransferase alpha subunit repeat, putative |
Trypanosoma brucei | Tb11.v5.1013 | Protein prenyltransferase alpha subunit repeat, putative |
Trypanosoma congolense | TcIL3000_10_9850 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509647.140 | Protein prenyltransferase alpha subunit repeat, putative |
Theileria parva | TP04_0873 | RAB geranylgeranyltransferase alpha subunit, putative |
Trichomonas vaginalis | TVAG_430990 | protein farnesyltransferase alpha subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.11640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.11640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.11640 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.11640 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_M57.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_M57.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_M57.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_M57.2 | Caenorhabditis elegans | slow growth | wormbase |
YJL031C | Saccharomyces cerevisiae | inviable | yeastgenome |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.