Detailed view for TcCLB.509707.25

Basic information

TDR Targets ID: 46249
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1603 | Length (AA): 447 | MW (Da): 49999 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01612   3'-5' exonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0005622   intracellular  
GO:0003676   nucleic acid binding  
GO:0008408   3'-5' exonuclease activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
106 334 2fby (A) 58 228 30.00 0 1 0.53 0.17
138 338 2fby (A) 38 231 23.00 0 1 0.49 -0.16
106 329 2fby (A) 58 223 33.00 0 0.99 0.489519 0.78
110 159 3k8k (A) 203 254 36.00 0.15 0.02 0.270257 1.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_132011)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0278593   3'-5' exonuclease domain-containing protein
Dictyostelium discoideum DDB_G0278079   3'-5' exonuclease domain-containing protein
Drosophila melanogaster Dmel_CG6744   CG6744 gene product from transcript CG6744-RA
Homo sapiens ENSG00000081177   exonuclease 3'-5' domain containing 2
Leishmania braziliensis LbrM.31.3040   hypothetical protein, conserved
Leishmania donovani LdBPK_312780.1   hypothetical protein, conserved
Leishmania infantum LinJ.31.2780   hypothetical protein, conserved
Leishmania major LmjF.31.2700   hypothetical protein, conserved
Leishmania mexicana LmxM.30.2700   hypothetical protein, conserved
Mus musculus ENSMUSG00000032705   exonuclease 3'-5' domain containing 2
Schmidtea mediterranea mk4.000498.03   AT25352p
Trypanosoma cruzi TcCLB.508065.60   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509707.25   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509707.20   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509707.25 (Trypanosoma cruzi), hypothetical protein, conserved
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