Detailed view for PF3D7_0726500

Basic information

TDR Targets ID: 463
Plasmodium falciparum, ubiquitin carboxyl-terminal hydrolase, putative

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.9857 | Length (AA): 3183 | MW (Da): 373169 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0004221   ubiquitin thiolesterase activity  
GO:0005515   protein binding  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 25 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 242 2foj (A) 66 202 18.00 0 0.84 0.13 -0.82
809 1229 2f1z (A) 139 551 32.00 0 1 0.37 0.54
260 438 1vjv (A) 109 298 30.00 0.094 0.22 0.0351363 1.31
734 1161 3mhs (A) 1 459 18.00 0 0.71 0.180964 1.06
794 1231 2f1z (B) 128 553 30.00 0 1 0.350106 0.79
840 1228 2f1z (A) 141 550 34.00 0 1 0.276112 1.34
908 1157 5cvm (A) 61 340 32.00 0.00000000028 1 0.294442 1.22
959 1158 2y6e (A) 389 911 29.00 0.0016 0.84 0.174734 0.8
962 1160 4wa6 (D) 236 458 28.00 0.000029 0.88 0.0694196 1.19
1284 2249 2nyy (A) 338 1246 21.00 0.33 0.83 0.249387 1.55
1308 1475 4wat (A) 186 391 37.00 0.0013 0.14 0.30968 -0.05
1577 2497 3s5k (A) 66 996 25.00 0.19 0.91 0.20525 1.63
1991 2210 3uau (A) 31 272 30.00 0.005 0.33 0.0670172 1.13
2404 2595 4tql (A) 15 210 15.00 0.22 0.19 0.19382 -0.73
260 439 1vjv (A) 109 298 30.00 0.28 0.38 0.0746676 0.98
733 1242 2f1z (B) 66 553 26.00 0 1 -0.0827752 1.35
844 1232 2f1z (A) 141 550 34.00 0 1 0.289001 1.21
912 1161 5cvm (A) 61 340 32.00 0.00000000019 1 0.302549 1.14
963 1162 2y6e (A) 389 911 29.00 0.0012 0.94 0.17692 0.88
966 1949 3s5m (A) 179 1186 22.00 0.1 0.97 0.187996 1.55
1288 2256 2nyy (A) 338 1246 21.00 0.31 0.81 0.275307 1.47
1312 1487 4wat (A) 186 392 35.00 0.0079 0.16 0.259417 0.1
1651 1957 3n3m (A) 3 321 18.00 0.96 0.16 0.176167 -0.12
1998 2217 3uau (A) 31 272 30.00 0.0046 0.33 0.0671715 1.13
2084 2335 4lo6 (B) 368 620 25.00 0.83 0.73 0.140175 0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Oocyst, Sporozoite, sporozoite. Otto TD Zhanghi PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Ring, Female Gametocyte, Male Gametocyte, gametocyte, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite. Otto TD Zhanghi Lasonder PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite. Otto TD PlasmoDB
Show/Hide expression data references
  • Lasonder Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zhanghi A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127773)

Species Accession Gene Product
Arabidopsis thaliana AT3G11910   ubiquitin carboxyl-terminal hydrolase 13
Arabidopsis thaliana AT5G06600   ubiquitin carboxyl-terminal hydrolase 12
Babesia bovis BBOV_IV001730   ubiquitin carboxyl-terminal hydrolase, putative
Brugia malayi Bm1_38125   Ubiquitin carboxyl-terminal hydrolase family protein
Candida albicans CaO19.1777   putative ubiquitin-specific protease
Candida albicans CaO19.9344   putative ubiquitin-specific protease
Caenorhabditis elegans CELE_H19N07.2   Protein MATH-33, isoform C
Cryptosporidium hominis Chro.80181   ubiquitin carboxyl-terminal hydrolase
Cryptosporidium parvum cgd8_1530   ubiquitin carboxyl terminal hydrolase domain that is fused to a MATH domain
Dictyostelium discoideum DDB_G0276443   peptidase C19 family protein
Drosophila melanogaster Dmel_CG1490   Ubiquitin-specific protease 7
Echinococcus granulosus EgrG_001005800   ubiquitin carboxyl terminal hydrolase 7
Echinococcus granulosus EgrG_000875300   ubiquitin carboxyl terminal hydrolase 7
Echinococcus multilocularis EmuJ_001005800   ubiquitin carboxyl terminal hydrolase 7
Echinococcus multilocularis EmuJ_000875300   ubiquitin carboxyl terminal hydrolase 7
Homo sapiens ENSG00000187555   ubiquitin specific peptidase 7 (herpes virus-associated)
Leishmania braziliensis LbrM.34.1640   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania donovani LdBPK_351730.1   ubiquitin hydrolase, putative
Leishmania infantum LinJ.35.1730   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania major LmjF.35.1740   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania mexicana LmxM.34.1740   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Loa Loa (eye worm) LOAG_11307   hypothetical protein
Loa Loa (eye worm) LOAG_03615   ubiquitin carboxyl-terminal hydrolase
Mus musculus ENSMUSG00000022710   ubiquitin specific peptidase 7
Neospora caninum NCLIV_041690   Ubiquitin carboxyl-terminal hydrolase (EC 3.1.2.15), related
Oryza sativa 4324616   Os01g0771400
Oryza sativa 4352242   Os12g0489100
Oryza sativa 4342469   Os07g0163800
Oryza sativa 9270404   Os11g0573000
Plasmodium berghei PBANKA_0210600   ubiquitin carboxyl-terminal hydrolase, putative
Plasmodium falciparum PF3D7_0726500 this record   ubiquitin carboxyl-terminal hydrolase, putative
Plasmodium knowlesi PKNH_0211100   ubiquitin carboxyl-terminal hydrolase, putative
Plasmodium vivax PVX_081630   ubiquitin carboxyl-terminal hydrolase family 2, putative
Plasmodium yoelii PY01440   Ubiquitin carboxyl-terminal hydrolase family 2, putative
Saccharomyces cerevisiae YMR304W   Ubp15p
Schistosoma japonicum Sjp_0030710   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma japonicum Sjp_0311690   Ubiquitin carboxyl-terminal hydrolase 7, putative
Schistosoma mansoni Smp_089180   ubiquitin-specific peptidase 7 (C19 family)
Schmidtea mediterranea mk4.005337.00   Ubiquitin carboxyl-terminal hydrolase 7
Schmidtea mediterranea mk4.053550.00   Ubiquitin carboxyl-terminal hydrolase 7
Schmidtea mediterranea mk4.001874.04   Ubiquitin carboxyl-terminal hydrolase 7
Schmidtea mediterranea mk4.001402.00  
Schmidtea mediterranea mk4.008594.01   Ubiquitin carboxyl-terminal hydrolase 7
Schmidtea mediterranea mk4.000689.05   Ubiquitin carboxyl-terminal hydrolase 7
Schmidtea mediterranea mk4.000521.11  
Schmidtea mediterranea mk4.005489.05  
Schmidtea mediterranea mk4.005489.04   Ubiquitin carboxyl-terminal hydrolase 7
Trypanosoma brucei gambiense Tbg972.9.9090   ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Trypanosoma brucei Tb927.9.14470   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma congolense TcIL3000_0_31970   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.510761.70   ubiquitin hydrolase, putative
Toxoplasma gondii TGME49_289330   ubiquitin carboxyl-terminal hydrolase family 2 protein
Theileria parva TP03_0493   hypothetical protein
Theileria parva TP03_0494   ubiquitin carboxyl-terminal hydrolase, putative
Trichomonas vaginalis TVAG_464680   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_043710   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_475320   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_014330   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_422470   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_378280   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase

Essentiality

PF3D7_0726500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.4910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.4910 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.4910 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_H19N07.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_H19N07.2 Caenorhabditis elegans larval lethal wormbase
CELE_H19N07.2 Caenorhabditis elegans slow growth wormbase
PBANKA_0210600 Plasmodium berghei Essential plasmo
TGME49_289330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Compounds References
Homo sapiens ubiquitin specific peptidase 7 (herpes virus-associated) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0726500 (Plasmodium falciparum), ubiquitin carboxyl-terminal hydrolase, putative
Title for this comment
Comment