Detailed view for TcCLB.511461.20

Basic information

TDR Targets ID: 46489
Trypanosoma cruzi, tyrosine aminotransferase
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.831 | Length (AA): 416 | MW (Da): 46130 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00155   Aminotransferase class I and II

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0016847   1-aminocyclopropane-1-carboxylate synthase activity  
GO:0008483   transaminase activity  
GO:0004838   tyrosine transaminase activity  
GO:0003824   catalytic activity  
GO:0009072   aromatic amino acid family metabolic process  
GO:0009058   biosynthetic process  
GO:0006520   amino acid metabolic process  
GO:0006519   amino acid and derivative metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 416 1eji (A) 7 431 13.00 0 1 0.95 -0.04
4 415 1bw0 (A) 4 415 99.99 0 1 2.3 -2.19
4 415 1bw0 (A) 4 415 99.99 0 1 2.25918 -1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1BW0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128985)

Species Accession Gene Product
Arabidopsis thaliana AT5G53970   tyrosine aminotransferase
Arabidopsis thaliana AT4G28410   tyrosine transaminase family protein
Arabidopsis thaliana AT2G20610   S-alkyl-thiohydroximate lyase SUR1
Arabidopsis thaliana AT2G24850   tyrosine aminotransferase 3
Arabidopsis thaliana AT5G36160   tyrosine aminotransferase
Arabidopsis thaliana AT4G28420   tyrosine transaminase family protein
Brugia malayi Bm1_31005   tyrosine aminotransferase
Caenorhabditis elegans CELE_F42D1.2   Protein TATN-1
Dictyostelium discoideum DDB_G0287515   tyrosine aminotransferase
Drosophila melanogaster Dmel_CG1461   CG1461 gene product from transcript CG1461-RB
Homo sapiens 6898   tyrosine aminotransferase
Leishmania braziliensis LbrM.35.2580   tyrosine aminotransferase
Leishmania donovani LdBPK_362490.1   tyrosine aminotransferase
Leishmania infantum LinJ.36.2490   tyrosine aminotransferase
Leishmania major LmjF.36.2360   tyrosine aminotransferase
Leishmania mexicana LmxM.36.2360   tyrosine aminotransferase, putative
Loa Loa (eye worm) LOAG_03223   tyrosine aminotransferase
Mus musculus ENSMUSG00000001670   tyrosine aminotransferase
Oryza sativa 4329098   Os02g0302400
Oryza sativa 9267778   Os02g0306401
Oryza sativa 4340970   Os06g0345200
Oryza sativa 4350712   Os11g0552000
Oryza sativa 4329101   Os02g0302700
Schmidtea mediterranea mk4.013860.02  
Schmidtea mediterranea mk4.010921.01   Tyrosine aminotransferase
Schmidtea mediterranea mk4.004732.00   Tyrosine aminotransferase
Trypanosoma cruzi TcCLB.510187.50   tyrosine aminotransferase
Trypanosoma cruzi TcCLB.510795.10   tyrosine aminotransferase
Trypanosoma cruzi TcCLB.510187.40   tyrosine aminotransferase
Trypanosoma cruzi TcCLB.509041.10   tyrosine aminotransferase, putative
Trypanosoma cruzi TcCLB.510187.20   tyrosine aminotransferase, putative
Trypanosoma cruzi TcCLB.511461.20   tyrosine aminotransferase
Trypanosoma cruzi TcCLB.510187.30   tyrosine aminotransferase
Trypanosoma cruzi TcCLB.510187.70   tyrosine aminotransferase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Tyrosine aminotransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Trypanosoma cruzi ( 2 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    TcCLB.511461.20 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Trypanosoma cruzi ( 1 )

Bibliographic References

17 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511461.20 (Trypanosoma cruzi), tyrosine aminotransferase
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