Detailed view for NCLIV_006520

Basic information

TDR Targets ID: 476001
Neospora caninum, hypothetical protein
Source Database / ID: 

pI: 6.0612 | Length (AA): 580 | MW (Da): 64129 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01239   Protein prenyltransferase alpha subunit repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0018342   protein prenylation  
GO:0008318   protein prenyltransferase activity  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 216 1n95 (A) 97 243 36.00 0 0.99 0.576521 -0.44
55 252 3dss (A) 44 271 28.00 0.00000016 0.9 0.580279 -0.34
222 290 5frg (A) 343 417 35.00 0.38 0.71 0.621866 -2.17
419 476 2k3n (A) 3 60 40.00 0.046 0.05 0.4079 0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128459)

Species Accession Gene Product
Arabidopsis thaliana AT3G59380   farnesyltransferase A
Babesia bovis BBOV_III002550   protein prenyltransferase alpha subunit repeat domain containing protein
Brugia malayi Bm1_24725   Protein prenyltransferase alpha subunit repeat containing protein
Candida albicans CaO19.12280   alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)
Candida albicans CaO19.4817   alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)
Caenorhabditis elegans CELE_R02D3.5   Protein FNTA-1
Cryptosporidium hominis Chro.60290   farnesyltransferase
Cryptosporidium parvum cgd6_2510   farnesyltransferase
Dictyostelium discoideum DDB_G0283053   protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
Drosophila melanogaster Dmel_CG2976   CG2976 gene product from transcript CG2976-RB
Echinococcus granulosus EgrG_000631400   protein farnesyltransferase alpha subunit
Entamoeba histolytica EHI_074760   protein farnesyltransferase alpha subunit, putative
Echinococcus multilocularis EmuJ_000631400   protein farnesyltransferase alpha subunit
Giardia lamblia GL50803_15820   Rab geranylgeranyltransferase
Homo sapiens ENSG00000168522   farnesyltransferase, CAAX box, alpha
Loa Loa (eye worm) LOAG_09512   prenyltransferase alpha subunit repeat containing protein
Loa Loa (eye worm) LOAG_12157   hypothetical protein
Mus musculus ENSMUSG00000015994   farnesyltransferase, CAAX box, alpha
Neospora caninum NCLIV_006520   hypothetical protein
Oryza sativa 4347566   Os09g0514400
Plasmodium berghei PBANKA_1456000   protein farnesyltransferase subunit alpha, putative
Plasmodium falciparum PF3D7_1242600   protein farnesyltransferase subunit alpha
Plasmodium knowlesi PKNH_1461900   protein farnesyltransferase subunit alpha, putative
Plasmodium vivax PVX_101030   prenyltransferase alpha subunit, putative
Saccharomyces cerevisiae YKL019W   bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Schistosoma japonicum Sjp_0120990   ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative
Schistosoma mansoni Smp_091770   protein farnesyltransferase alpha subunit
Schmidtea mediterranea mk4.000226.09  
Toxoplasma gondii TGME49_297510   hypothetical protein
Theileria parva TP03_0712   hypothetical protein
Trichomonas vaginalis TVAG_257590   protein farnesyltransferase alpha subunit, putative
Trichomonas vaginalis TVAG_434060   protein farnesyltransferase alpha subunit, putative
Trichomonas vaginalis TVAG_230550   protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative
Trichomonas vaginalis TVAG_190520   protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative

Essentiality

NCLIV_006520 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R02D3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_R02D3.5 Caenorhabditis elegans larval arrest wormbase
CELE_R02D3.5 Caenorhabditis elegans larval lethal wormbase
CELE_R02D3.5 Caenorhabditis elegans sterile wormbase
YKL019W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1456000 Plasmodium berghei Essential plasmo
TGME49_297510 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus farnesyltransferase, CAAX box, alpha Compounds References
Saccharomyces cerevisiae bifunctional protein farnesyltransferase/protein geranylgeranyltransferase Compounds References
Rattus norvegicus geranylgeranyltransferase type-I Compounds References
Plasmodium falciparum protein farnesyltransferase subunit alpha Compounds References
Homo sapiens farnesyltransferase, CAAX box, alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_006520 (Neospora caninum), hypothetical protein
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