pI: 8.5282 |
Length (AA): 1193 |
MW (Da): 140317 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
230 | 531 | 2f84 (A) | 25 | 323 | 16.00 | 0.0000014 | 0.11 | 0.33 | -0.32 |
215 | 343 | 4py6 (A) | 1187 | 1312 | 17.00 | 0.94 | 0.01 | 0.205331 | -0.17 |
684 | 1181 | 3fd5 (B) | 6 | 377 | 22.00 | 0 | 1 | 0.079935 | 1.75 |
706 | 1011 | 3u0o (B) | 16 | 240 | 35.00 | 0.0000000037 | 1 | 0.123396 | 1.73 |
742 | 885 | 3m84 (A) | 44 | 195 | 18.00 | 0.72 | 0.64 | 0.168904 | 0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, early trophozoite, late trophozoite, Oocyst, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Female Gametocyte, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_128344)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_37305 | selenium donor protein |
Caenorhabditis elegans | CELE_Y45F10A.4 | Protein SELD-1 |
Dictyostelium discoideum | DDB_G0282367 | selenide water dikinase |
Drosophila melanogaster | Dmel_CG8553 | Selenide,water dikinase |
Escherichia coli | b1764 | selenophosphate synthase |
Echinococcus granulosus | EgrG_001082900 | selenide water dikinase |
Echinococcus multilocularis | EmuJ_001082900 | |
Homo sapiens | ENSG00000179918 | selenophosphate synthetase 2 |
Homo sapiens | ENSG00000086475 | selenophosphate synthetase 1 |
Leishmania braziliensis | LbrM.35.5670 | selenophosphate synthetase, putative |
Leishmania donovani | LdBPK_365650.1 | selenophosphate synthetase, putative |
Leishmania infantum | LinJ.36.5650 | selenophosphate synthetase, putative |
Leishmania major | LmjF.36.5410 | selenophosphate synthetase, putative |
Leishmania mexicana | LmxM.36.5410 | selenophosphate synthetase, putative |
Loa Loa (eye worm) | LOAG_01464 | selenium donor protein |
Mus musculus | ENSMUSG00000026662 | selenophosphate synthetase 1 |
Mus musculus | 20768 | selenophosphate synthetase 2 |
Neospora caninum | NCLIV_019590 | Selenophosphate synthase (EC 2.7.9.3), related |
Plasmodium berghei | PBANKA_0811600 | selenide water dikinase, putative |
Plasmodium falciparum | PF3D7_0910400 | selenide water dikinase, putative |
Plasmodium knowlesi | PKNH_0708400 | selenide water dikinase, putative |
Plasmodium vivax | PVX_098960 | selenophosphate synthetase, putative |
Plasmodium yoelii | PY05530 | selenophosphate synthetase |
Schistosoma japonicum | Sjp_0303300 | ko:K01008 selenide,water dikinase [EC2.7.9.3], putative |
Schistosoma japonicum | Sjp_0077310 | Selenide, water dikinase, putative |
Schistosoma mansoni | Smp_095650 | selinide water dikinase |
Schmidtea mediterranea | mk4.009858.03 | Probable selenide, water dikinase |
Schmidtea mediterranea | mk4.009858.01 | Probable selenide, water dikinase |
Schmidtea mediterranea | mk4.004975.02 | Probable selenide, water dikinase |
Schmidtea mediterranea | mk4.032231.00 | Probable selenide, water dikinase |
Trypanosoma brucei gambiense | Tbg972.10.11500 | selenophosphate synthetase, putative |
Trypanosoma brucei | Tb927.10.9410 | Selenophosphate synthetase 2 |
Trypanosoma congolense | TcIL3000_10_8170 | selenophosphate synthetase, putative |
Trypanosoma cruzi | TcCLB.508717.36 | selenophosphate synthetase, putative |
Trypanosoma cruzi | TcCLB.504079.6 | selenophosphate synthetase, putative |
Toxoplasma gondii | TGME49_280560 | selenide, water dikinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.9410 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.9410 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.9410 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.9410 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1764 | Escherichia coli | non-essential | goodall |
TGME49_280560 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.