Detailed view for NCLIV_046190

Basic information

TDR Targets ID: 481225
Neospora caninum, Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a

Source Database / ID: 

pI: 6.8881 | Length (AA): 6755 | MW (Da): 710183 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00439   Bromodomain
PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
254 366 5lpn (B) 922 1045 21.00 0 0 0.360328 -1.76
254 455 4uos (A) 1 187 15.00 0 0.02 0.238504 -1.72
261 364 5hmo (A) 801 915 28.00 0.38 0.02 0.291296 -1.25
842 1047 4tql (A) 10 221 10.00 0.0042 0.04 0.171996 -1.09
1425 1481 1x6e (A) 9 66 28.00 0.012 0.07 0.0979382 0.46
2030 2160 2ri7 (A) 23 162 31.00 0.000000045 1 0.294293 -0.06
2030 2071 1we9 (A) 22 59 42.00 0.28 1 0.139118 0.96
2075 2167 3nxb (A) 442 535 27.00 0 0.99 0.500368 -1.53
2077 2167 1e6i (A) 337 428 31.00 0 0.99 0.534072 -1.47
2794 2842 2mny (A) 311 356 43.00 0.26 0.38 0.353754 0
2795 2842 3asl (A) 318 363 41.00 0.38 0.79 0.411006 -0.06
3053 3201 2kr0 (A) 126 312 36.00 0.17 0.33 -0.0910423 1.85
3259 3377 2mqa (A) 22 141 16.00 0 0.01 0.151817 -0.06
6571 6755 2w5y (A) 3793 3969 48.00 0 1 0.504287 0.12
6596 6755 5f6k (C) 4758 4911 41.00 0 1 0.448286 -0.35
6621 6750 3bo5 (A) 136 280 32.00 0.00083 0.83 0.237145 0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130642)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8651   trithorax
Homo sapiens ENSG00000272333   lysine (K)-specific methyltransferase 2B
Homo sapiens ENSG00000118058   lysine (K)-specific methyltransferase 2A
Mus musculus ENSMUSG00000006307   lysine (K)-specific methyltransferase 2B
Mus musculus ENSMUSG00000002028   lysine (K)-specific methyltransferase 2A
Neospora caninum NCLIV_046190   Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a
Schistosoma japonicum Sjp_0214100   ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative
Schistosoma mansoni Smp_070210   mixed-lineage leukemia protein mll
Schmidtea mediterranea mk4.059086.03  
Toxoplasma gondii TGME49_226810   histone lysine methyltransferase SET1

Essentiality

NCLIV_046190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_226810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lysine (K)-specific methyltransferase 2A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_046190 (Neospora caninum), Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a
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