Detailed view for NCLIV_027500

Basic information

TDR Targets ID: 481520
Neospora caninum, bromodomain-containing protein, putative
Source Database / ID: 

pI: 4.8838 | Length (AA): 1510 | MW (Da): 159908 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00439   Bromodomain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 140 5n17 (A) 191 317 29.00 0 1 0.524155 -1.09
30 133 3d7c (A) 730 831 29.00 0 1 0.568274 -1.6
47 110 3u5m (A) 975 1039 44.00 0.000038 0.75 0.434384 0.01
53 131 3d7c (A) 753 824 43.00 0.00000058 0.93 0.541318 -0.68
425 542 4py6 (A) 1193 1309 34.00 0 1 0.686046 -2.07
467 535 5pg1 (A) 1901 1965 49.00 0.00000047 1 0.673695 -1.1
1095 1289 5cwq (A) 23 205 28.00 0.33 0.99 0.383139 -0.07
1253 1459 5cwm (A) 18 216 20.00 0.62 0.12 0.291386 -0.47
1269 1497 5cwp (A) 3 229 18.00 0.037 0.4 0.316956 -0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126719)

Species Accession Gene Product
Arabidopsis thaliana AT1G06230   transcription factor GTE4
Arabidopsis thaliana AT1G73150   transcription factor GTE3
Arabidopsis thaliana AT1G17790   DNA-binding bromodomain-containing protein
Arabidopsis thaliana AT5G14270   bromodomain and extraterminal domain protein 9
Arabidopsis thaliana AT5G10550   global transcription factor group E2
Arabidopsis thaliana AT3G01770   bromodomain and extraterminal domain protein 10
Arabidopsis thaliana AT5G65630   global transcription factor group E7
Arabidopsis thaliana AT5G63320   nuclear protein X1
Brugia malayi Bm1_34900   Bromodomain containing protein
Brugia malayi Bm1_34905   hypothetical protein
Brugia malayi Bm1_24310   Bromodomain containing protein
Candida albicans CaO19.978   two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1
Candida albicans CaO19.8593   two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1
Caenorhabditis elegans CELE_F57C7.1   Protein BET-2, isoform A
Caenorhabditis elegans CELE_F59F5.7   Protein F59F5.7
Caenorhabditis elegans CELE_Y119C1B.8   Protein BET-1, isoform B
Dictyostelium discoideum DDB_G0271118   bromodomain-containing protein
Dictyostelium discoideum DDB_G0293800   BRD family protein kinase
Dictyostelium discoideum DDB_G0270170   BRD family protein kinase
Drosophila melanogaster Dmel_CG2252   female sterile (1) homeotic
Drosophila melanogaster Dmel_CG30417   CG30417 gene product from transcript CG30417-RA
Drosophila melanogaster Dmel_CG13597   testis-specifically expressed bromodomain containing protein-1
Echinococcus granulosus EgrG_000332900   bromodomain containing 2
Entamoeba histolytica EHI_138300   bromodomain-containing protein
Entamoeba histolytica EHI_085030   bromodomain-containing protein
Entamoeba histolytica EHI_049790   bromodomain-containing protein
Echinococcus multilocularis EmuJ_000158100   Bromodomain containing protein
Echinococcus multilocularis EmuJ_000332900   bromodomain containing 2
Giardia lamblia GL50803_21502   Kinase, putative
Homo sapiens ENSG00000204256   bromodomain containing 2
Homo sapiens ENSG00000141867   bromodomain containing 4
Homo sapiens ENSG00000169925   bromodomain containing 3
Homo sapiens ENSG00000137948   bromodomain, testis-specific
Loa Loa (eye worm) LOAG_11871   bromodomain containing protein
Loa Loa (eye worm) LOAG_09036   hypothetical protein
Mus musculus ENSMUSG00000026918   bromodomain containing 3
Mus musculus ENSMUSG00000024335   bromodomain containing 2
Mus musculus ENSMUSG00000024002   bromodomain containing 4
Mus musculus ENSMUSG00000029279   bromodomain, testis-specific
Neospora caninum NCLIV_027500   bromodomain-containing protein, putative
Oryza sativa 4337044   Os04g0623100
Oryza sativa 4344864   Os08g0192800
Oryza sativa 4328885   Os02g0250300
Oryza sativa 4337040   Os04g0622000
Oryza sativa 4329897   Os02g0601800
Oryza sativa 9266809   Os04g0622700
Onchocerca volvulus OVOC2400  
Saccharomyces cerevisiae YLR399C   Bdf1p
Saccharomyces cerevisiae YDL070W   Bdf2p
Schistosoma japonicum Sjp_0020890   ko:K08871 bromodomain-containing protein, putative
Schistosoma mansoni Smp_147950   bromodomain-containing protein 3 brd3
Schmidtea mediterranea mk4.014255.00  
Schmidtea mediterranea mk4.014255.01  
Schmidtea mediterranea mk4.005178.00  
Schmidtea mediterranea mk4.000491.01  
Schmidtea mediterranea mk4.000589.07  
Schmidtea mediterranea mk4.000489.01  
Toxoplasma gondii TGME49_258990   bromodomain-containing protein
Trichomonas vaginalis TVAG_079240   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_150070   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_474890   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_308310   bromodomain containing protein, putative
Trichomonas vaginalis TVAG_469130   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_109370   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_297080   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_103940   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_108790   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_319080   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_344970   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_303380   conserved hypothetical protein
Trichomonas vaginalis TVAG_390850   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_311350   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_267890   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_496260   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_304270   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_103320   histone acetyltransferase gcn5, putative
Trichomonas vaginalis TVAG_029190   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_417990   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_185370   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_214050   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_466080   bromodomain-containing protein 4, brd4, putative
Trichomonas vaginalis TVAG_127840   bromodomain-containing protein, putative
Trichomonas vaginalis TVAG_334430   bromodomain-containing protein, putative

Essentiality

NCLIV_027500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y119C1B.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y119C1B.8 Caenorhabditis elegans larval arrest wormbase
CELE_Y119C1B.8 Caenorhabditis elegans sterile wormbase
TGME49_258990 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain containing 3 Compounds References
Homo sapiens bromodomain containing 2 Compounds References
Mus musculus bromodomain containing 4 Compounds References
Homo sapiens bromodomain, testis-specific Compounds References
Homo sapiens bromodomain containing 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_027500 (Neospora caninum), bromodomain-containing protein, putative
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