Detailed view for NCLIV_048420

Basic information

TDR Targets ID: 481631
Neospora caninum, hypothetical protein
Source Database / ID: 

pI: 4.4653 | Length (AA): 326 | MW (Da): 35030 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04683   Proteasome complex subunit Rpn13 ubiquitin receptor
PF16550   UCH-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005634   nucleus  

Metabolic Pathways

Proteasome (KEGG)
Epstein-Barr virus infection (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 322 2kr0 (A) 18 319 24.00 0 0.67 1.05612 1.58
13 169 2kr0 (A) 18 166 42.00 0 1 0.928595 0.04
13 301 2kr0 (A) 18 405 29.00 0 1 0.818503 0.41
165 292 2mkz (A) 1 133 22.00 0 0.94 0.659838 -0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128928)

Species Accession Gene Product
Arabidopsis thaliana AT2G26590   regulatory particle non-ATPase 13
Babesia bovis BBOV_III006190   conserved hypothetical protein
Brugia malayi Bm1_46000   Adhesion regulating molecule conserved region family protein
Candida albicans CaO19.8660   similar to S. cerevisiae RPN13 (YLR421C) subunit of the 19S regulatory particle of the 26S proteasome
Candida albicans CaO19.1058   similar to S. cerevisiae RPN13 (YLR421C) subunit of the 19S regulatory particle of the 26S proteasome
Caenorhabditis elegans CELE_C56G2.7   Protein C56G2.7
Dictyostelium discoideum DDB_G0272624   adhesion regulating molecule family protein
Dictyostelium discoideum DDB_G0274093   adhesion regulating molecule family protein
Drosophila melanogaster Dmel_CG13349   Regulatory particle non-ATPase 13
Drosophila melanogaster Dmel_CG6789   Regulatory particle non-ATPase 13-related
Echinococcus granulosus EgrG_000592000   adhesion regulating molecule 1
Echinococcus multilocularis EmuJ_000592000   adhesion regulating molecule 1
Homo sapiens ENSG00000130706   adhesion regulating molecule 1
Loa Loa (eye worm) LOAG_04044   hypothetical protein
Mus musculus ENSMUSG00000039041   adhesion regulating molecule 1
Neospora caninum NCLIV_048420   hypothetical protein
Oryza sativa 4339809   Os05g0594800
Onchocerca volvulus OVOC8619   Proteasomal ubiquitin receptor ADRM1 homolog
Saccharomyces cerevisiae YLR421C   proteasome regulatory particle lid subunit RPN13
Schistosoma mansoni Smp_080040   adhesion regulating molecule 1 (110 kD cell membrane glycoprotein)
Schmidtea mediterranea mk4.008467.00  
Schmidtea mediterranea mk4.001589.00   Putative adhesion regulating molecule 1
Schmidtea mediterranea mk4.010357.00  
Toxoplasma gondii TGME49_224110   adhesion regulating molecule region protein, putative

Essentiality

NCLIV_048420 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C56G2.7 Caenorhabditis elegans larval arrest wormbase
TGME49_224110 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adhesion regulating molecule 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_048420 (Neospora caninum), hypothetical protein
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