pI: 5.6311 |
Length (AA): 476 |
MW (Da): 51547 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 476 | 1kvk (A) | 7 | 383 | 17.00 | 0 | 1 | 0.814293 | 0.79 |
133 | 452 | 3k17 (A) | 90 | 343 | 31.00 | 0.000014 | 1 | 0.678369 | 0.85 |
261 | 380 | 5bv5 (D) | 171 | 285 | 33.00 | 0.26 | 0.12 | 0.157201 | 1.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_131773)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G31910 | GHMP kinase family protein |
Candida albicans | CaO19.4606 | phosphomevalonate kinase |
Candida albicans | CaO19.12076 | phosphomevalonate kinase |
Dictyostelium discoideum | DDB_G0292666 | hypothetical protein |
Leishmania braziliensis | LbrM.15.1450 | phosphomevalonate kinase protein, putative |
Leishmania donovani | LdBPK_151510.1 | phosphomevalonate kinase-like protein |
Leishmania infantum | LinJ.15.1510 | phosphomevalonate kinase protein, putative |
Leishmania major | LmjF.15.1460 | phosphomevalonate kinase protein, putative |
Leishmania mexicana | LmxM.15.1460 | phosphomevalonate kinase-like protein |
Mus musculus | 102641231 | phosphomevalonate kinase-like |
Oryza sativa | 4332275 | Os03g0253100 |
Saccharomyces cerevisiae | YMR220W | phosphomevalonate kinase |
Trypanosoma brucei gambiense | Tbg972.9.2730 | phosphomevalonate kinase protein, putative |
Trypanosoma brucei | Tb927.9.5170 | phosphomevalonate kinase protein, putative |
Trypanosoma cruzi | TcCLB.507913.20 | phosphomevalonate kinase protein, putative |
Trypanosoma cruzi | TcCLB.508277.140 | phosphomevalonate kinase protein, putative |
Trichomonas vaginalis | TVAG_128700 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.3690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3690 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.3690 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YMR220W | Saccharomyces cerevisiae | inviable | yeastgenome |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.