pI: 4.3501 |
Length (AA): 107 |
MW (Da): 11749 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
14 | 107 | 2daf (A) | 1 | 95 | 23.00 | 0 | 1 | 1.22 | -0.44 |
26 | 104 | 1wyw (B) | 19 | 97 | 47.00 | 0 | 1 | 1.47 | -1.76 |
29 | 96 | 1wm3 (A) | 18 | 85 | 51.00 | 0 | 1 | 1.46 | -2.19 |
1 | 104 | 2k8h (A) | 1 | 102 | 71.00 | 0 | 1 | 1.80616 | -0.45 |
28 | 103 | 5jp1 (B) | 20 | 95 | 47.00 | 0 | 1 | 1.43148 | -1.62 |
72 | 106 | 1x1m (A) | 71 | 105 | 11.00 | 0.0024 | 0.01 | 0.495303 | -0.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127053)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G55856 | putative small ubiquitin-related modifier 8 |
Arabidopsis thaliana | AT5G55160 | small ubiquitin-related modifier 2 |
Arabidopsis thaliana | AT4G26840 | small ubiquitin-related modifier 1 |
Babesia bovis | BBOV_IV003900 | ubiquitin-like protein, putative |
Brugia malayi | Bm1_45210 | Ubiquitin-like protein SMT3 |
Candida albicans | CaO19.670 | kinetochore protein |
Candida albicans | CaO19.8287 | kinetochore protein |
Caenorhabditis elegans | CELE_K12C11.2 | Protein SMO-1 |
Cryptosporidium hominis | Chro.80490 | ubiquitin-like protein |
Cryptosporidium parvum | cgd8_4260 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0286189 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4494 | CG4494 gene product from transcript CG4494-RA |
Drosophila melanogaster | Dmel_CG43069 | CG43069 gene product from transcript CG43069-RA |
Echinococcus granulosus | EgrG_001169800 | Small ubiquitin modifier 2 |
Entamoeba histolytica | EHI_170060 | ubiquitin like protein |
Echinococcus multilocularis | EmuJ_001169800 | Small ubiquitin modifier 2 |
Giardia lamblia | GL50803_7760 | Sentrin |
Homo sapiens | ENSG00000184900 | small ubiquitin-like modifier 3 |
Homo sapiens | ENSG00000116030 | small ubiquitin-like modifier 1 |
Leishmania braziliensis | LbrM.08.0500 | small ubiquitin protein, putative |
Leishmania donovani | LdBPK_080480.1 | small ubiquitin protein, putative |
Leishmania infantum | LinJ.08.0480 | small ubiquitin protein, putative |
Leishmania major | LmjF.08.0470 | small ubiquitin protein, putative |
Leishmania mexicana | LmxM.08.0470 | small ubiquitin protein, putative |
Loa Loa (eye worm) | LOAG_01479 | SMO-1 protein |
Mus musculus | 102640040 | small ubiquitin-related modifier 2-like |
Mus musculus | ENSMUSG00000020738 | SMT3 suppressor of mif two 3 homolog 2 (yeast) |
Mus musculus | ENSMUSG00000020265 | SMT3 suppressor of mif two 3 homolog 3 (yeast) |
Mus musculus | 101056240 | small ubiquitin-related modifier 2-like |
Mus musculus | 102642499 | small ubiquitin-related modifier 2-like |
Mus musculus | ENSMUSG00000026021 | SMT3 suppressor of mif two 3 homolog 1 (yeast) |
Neospora caninum | NCLIV_039480 | hypothetical protein |
Oryza sativa | 4324359 | Os01g0918200 |
Oryza sativa | 4324360 | Os01g0918300 |
Plasmodium berghei | PBANKA_1105400 | small ubiquitin-related modifier, putative |
Plasmodium falciparum | PF3D7_0505800 | small ubiquitin-related modifier |
Plasmodium knowlesi | PKNH_1027800 | small ubiquitin-related modifier, putative |
Plasmodium vivax | PVX_097850 | small ubiquitin-related modifier, putative |
Saccharomyces cerevisiae | YDR510W | SUMO family protein SMT3 |
Schistosoma japonicum | Sjp_0065660 | Small ubiquitin-related modifier 2 precursor, putative |
Schistosoma mansoni | Smp_045510 | ubiquitin-like protein sumo/smt3-related |
Schmidtea mediterranea | mk4.002820.01 | Small ubiquitin modifier 1 |
Schmidtea mediterranea | mk4.004710.01 | Small ubiquitin modifier 1 |
Schmidtea mediterranea | mk4.008996.01 | Small ubiquitin modifier 1 |
Trypanosoma brucei gambiense | Tbg972.5.4470 | small ubiquitin protein, putative |
Trypanosoma brucei | Tb927.5.3210 | small ubiquitin-related modifier |
Trypanosoma cruzi | TcCLB.511661.50 | small ubiquitin protein, putative |
Trypanosoma cruzi | TcCLB.507809.70 | small ubiquitin protein, putative |
Toxoplasma gondii | TGME49_266460 | small ubiquitin family modifier, putative |
Theileria parva | TP01_1040 | ubiquitin, putative |
Trichomonas vaginalis | TVAG_190260 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3210 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3210 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3210 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K12C11.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K12C11.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K12C11.2 | Caenorhabditis elegans | sterile | wormbase |
YDR510W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1105400 | Plasmodium berghei | Essential | plasmo |
TGME49_266460 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | small ubiquitin-like modifier 1 | Compounds | References |