Detailed view for TcCLB.484299.10

Basic information

TDR Targets ID: 50541
Trypanosoma cruzi, trypanothione reductase, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.9575 | Length (AA): 189 | MW (Da): 20442 | Paralog Number: 498

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02852   Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF07992   Pyridine nucleotide-disulphide oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0016491   oxidoreductase activity  
GO:0050660   FAD binding  
GO:0045454   cell redox homeostasis  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 184 1aog (A) 304 487 98.00 0 1 2.1 -0.68
2 185 1h6v (A) 312 496 34.00 0 1 1.36 -0.15
1 184 1aog (A) 304 487 98.00 0 1 2.06314 -0.21
88 171 4la1 (A) 500 584 38.00 0 0.99 0.925844 -0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1AOG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1BZL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1GXF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1NDA:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4NEW:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 5658   16167   56222   501341   563988  
Annotator: millerja@u.washington.edu. Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation.. References: 17017892
growth (GO:0040007) decreased (PATO:0000468) inferred from animal model system (ECO:0000179) Trypanosoma cruzi 956   5658   132257  
Annotator: millerja@u.washington.edu. Comment: . References: 15194137
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro assay (ECO:0000181) Trypanosoma cruzi 813   5658   26853   504139   525512   535744   561049   567662   573089   573090  
Annotator: millerja@u.washington.edu. Comment: Inhibition of epimastigotes; Paglini-Oliva & Rivarola 2003. Central nervous system agents used as Trypanosoma cruzi infection chemotherapy: phenothiazines and related compounds. Current Medicinal Chemistry - Anti-Infective Agents 2(4): 323-333.. References:
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from animal model system (ECO:0000179) Trypanosoma cruzi 813   561049   573089   573090  
Annotator: millerja@u.washington.edu. Comment: Parasites rendered non-infective in mice; Paglini-Oliva & Rivarola 2003. Central nervous system agents used as Trypanosoma cruzi infection chemotherapy: phenothiazines and related compounds. Current Medicinal Chemistry - Anti-Infective Agents 2(4): 323-333.. References:
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from in vitro assay (ECO:0000181) Trypanosoma cruzi 5658  
Annotator: millerja@u.washington.edu. Comment: Lethal to trypomastigotes; also verified in mice; Paglini-Oliva & Rivarola 2003. Central nervous system agents used as Trypanosoma cruzi infection chemotherapy: phenothiazines and related compounds. Current Medicinal Chemistry - Anti-Infective Agents 2(4): 323-333.. References:
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 813   956   2432   5658   6060   9043   13969   16167   16606   36154   56222   57921   73229   503939   503941   539326   550091   558535   560601   561049   563988   573089   573806   573807   573808   573809   577897   583295   585401   912717   912718   912719   912720   912721   912722   912723  
Annotator: millerja@u.washington.edu. Comment: . References: 11328673 17439174 19296695 19747949
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) trypomastigote (BTO:0001398) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 912698  
Annotator: millerja@u.washington.edu. Comment: Compound 3 in Figure 8: J. B. Baell and G. A. Holloway, U.S. patent application 61/092029; note that the authors question whether activity of this (or other compounds studied in this paper) was actually against TR.. References: 19364854
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 912738   912739   912740  
Annotator: millerja@u.washington.edu. Comment: Compound structures in Figure 1 of referenced publication. References: 3135548

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

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Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.1102 0.323 0.3186
0.0026 0.2803 0.2803
0.0425 0.3027 0.3013
0.0532 0.3934 0.422
0.0397 0.281 0.2897
0.0142 0.2506 0
0.0823 0.3284 0.3412
0.0092 0.3276 0
0.0264 0.3357 0.3357
0.0995 0.2699 0.2695
0.3055 0.3016 0.3016
0.0264 0.3357 0.3357
0.0584 0.2837 0.2832
0.0074 0.274 0.1819
0.077 0.2624 0.3295
0.0393 0.2799 0.2882
0.3225 0.3019 0.3018
0.0141 0.2632 0.2209
0.0994 0.3298 0.3295
0.0936 0.3286 0.3281
0.1128 0.3195 0.3163
0.0189 0.3154 0.3151
0.0196 0.2778 0.2706
0.0159 0.2644 0
0.007 0.2897 0.2897
0.0768 0.3432 0.3424
0.0773 0.3419 0.3419
0.1323 0.3222 0.3205
0.1189 0.2816 0.2815
0.0513 0.4283 0.4748
0.1211 0.374 0.3753
0.0768 0.3134 0.3134
0.0719 0.2708 0.2707
0.0857 0.3138 0.3101
0.0136 0.2613 0.2613
0.0784 0.3108 0.3108
0.045 0.2803 0.2803
0.0091 0.2612 0.2803
0.0939 0.3168 0.315
0.006 0.3229 0.4934
0.0786 0.2619 0.2619
0.0904 0.3229 0.3194
0.0435 0.2919 0.2904
0.0613 0.2925 0.3053
0.0074 0.274 0.1819
0.0436 0.2943 0.2969
0.0274 0.2803 0.2803
0.0411 0.2907 0.2897
0.0244 0.287 0.2917
0.1084 0.3619 0.3619
0.0853 0.2648 0.2656
0.127 0.3233 0.3208
0.0132 0.2817 0.2817
0.0868 0.2518 0.3268
0.0863 0.3439 0.3439
0.1339 0.3247 0.3354
0.0382 0.2735 0.2814
0.0986 0.3208 0.2803
0.0268 0.2658 0.3452
0.0303 0.3271 0.2803
0.0481 0.395 0.474
0.0207 0.2835 0.2803
0.0284 0.2662 0.3451
0.0251 0.3338 0.3338
0.0753 0.2689 0.2679
0.0202 0.271 0
0.0581 0.2828 0.3524
0.0545 0.2675 0.2661
0.0768 0.3432 0.3424
0.0333 0.2939 0.3829
0.1448 0.3401 0.3401
0.0087 0.3047 0.2803
0.0117 0.3107 0.3107
0.0712 0.2864 0.2859
0.0592 0.2848 0.2837
0.0333 0.2939 0.3829
0.1132 0.319 0.3245
0.0268 0.2658 0.3452
0.0553 0.3906 0.4205
0.0067 0.2803 0.2803
0.0359 0.2794 0.2787
0.0926 0.3337 0.3337
0.0553 0.2948 0.2803
0.0111 0.281 0.2803
0.0229 0.3233 0.3233
0.1306 0.3228 0.3211
0.0282 0.2663 0.3459
0.1258 0.323 0.3213
0.1323 0.3222 0.3205
0.0074 0.274 0.1819
0.0057 0.418 0.4946
0.1448 0.3401 0.3401
0.1224 0.3229 0.3204
0.0483 0.325 0.3225
0.0018 0.2763 0.2803
0.0553 0.2593 0.2998
0.0233 0.2855 0.2848
0.1327 0.3585 0.3584
0.0445 0.2922 0.2904
0.0994 0.3298 0.3295
0.0074 0.2938 0.2803
0.0044 0.2508 0.2803
0.0058 0.4934 0.4934
0.0117 0.3107 0.3107
0.0868 0.2518 0.3268
0.0055 0.2603 0
0.0219 0.3039 0.2972
0.1153 0.3209 0.3162
0.0065 0.257 0.2913
0.1007 0.3353 0.3329
0.1448 0.3401 0.3401
0.1377 0.3288 0.3353
0.0754 0.2633 0.2633
0.0776 0.2754 0.2745
0.0073 0.2515 0.2515
0.0933 0.3187 0.3186
0.0743 0.2697 0.2693
0.0707 0.3228 0.322
0.0054 0.3888 0.2536
0.0047 0.2508 0.2803
0.138 0.3277 0.3277
0.0122 0.2868 0.2803
0.0276 0.268 0.3452
0.0254 0.3435 0.2803
0.0543 0.2674 0.2663
0.0073 0.253 0.2505
0.007 0.2731 0
0.007 0.2897 0.2897
0.0572 0.2834 0.3526
0.0786 0.2684 0.2683
0.1028 0.3244 0.3239
0.1153 0.3209 0.3162
0.1132 0.319 0.3245
0.136 0.3225 0.3208
0.0059 0.5071 0.5071
0.0405 0.2917 0.2901
0.0091 0.3206 0.2803
0.0409 0.2878 0.2968
0.0118 0.2656 0.3214
0.0242 0.2817 0.2812
0.0278 0.3382 0.3357
0.0367 0.3186 0.2803
0.1337 0.3251 0.3228
0.0753 0.2689 0.2679
0.0956 0.2661 0.2829
0.019 0.2803 0.2803
0.0073 0.2867 0.2847
0.0722 0.2707 0.2705
0.0118 0.2817 0.2803
0.125 0.3237 0.3212
0.007 0.2897 0.2897
0.0911 0.3177 0.3121
0.0519 0.3419 0.3401
0.0997 0.3229 0.3216
0.0068 0.2655 0.2258
0.0144 0.3123 0.3123
0.0294 0.3382 0.3357
0.0065 0.2842 0.2803
0.1122 0.3211 0.3192
0.009 0.2803 0.2803
0.0393 0.2799 0.2882
0.1435 0.3265 0.3246
0.1207 0.3251 0.3237
0.1389 0.3234 0.3217
0.1004 0.2708 0.2708
0.0282 0.2669 0.3452
0.0219 0.3039 0.2972
0.0768 0.3432 0.3424
0.0302 0.2976 0.333
0.0072 0.2803 0.2803
0.0276 0.2673 0.3452
0.0154 0.2803 0.2803
0.0075 0.2537 0.2513
0.089 0.2765 0.2763
0.0185 0.2745 0.2744
0.0046 0.2803 0.2803
0.0118 0.2656 0.3214
0.007 0.2897 0.2897
0.009 0.2607 0.2334
0.0988 0.2698 0.2694
0.0768 0.3432 0.3424
0.0054 0.3888 0.2536
0.0846 0.312 0.3083
0.0268 0.2669 0.3452
0.1002 0.3268 0.3267
0.0333 0.2939 0.3829
0.0224 0.2564 0.2224
0.1224 0.3444 0.3442
0.0445 0.2907 0.2905
0.0284 0.2662 0.3451
0.0768 0.3134 0.3134
0.0154 0.2803 0.2803
0.038 0.2617 0.2716
0.0055 0.2699 0.2721
0.0114 0.3215 0.2803
0.0053 0.3462 0
0.0328 0.2781 0.2781
0.1002 0.3268 0.3267
0.0064 0.3963 0
0.0749 0.2695 0.2681
0.0868 0.2518 0.3268
0.0207 0.2835 0.2803
0.0065 0.2731 0
0.024 0.3292 0.3368
0.0781 0.2685 0.2684
0.1049 0.3203 0.3175
0.1364 0.3261 0.3255
0.0768 0.3432 0.3424
0.0077 0.2681 0.2803
0.0397 0.2907 0.2897
0.0451 0.3376 0.2803
0.0278 0.3382 0.3357
0.1133 0.3189 0.3167
0.007 0.2816 0.2816
0.0076 0.2532 0.2508
0.0067 0.2803 0.2803
0.0652 0.3427 0.3424
0.0997 0.3229 0.3216
0.0323 0.3179 0.385
0.1448 0.3401 0.3401
0.1292 0.3267 0.3267
0.0213 0.3266 0.3073
0.0596 0.2852 0.2836
0.0049 0.2508 0.2803
0.0254 0.3327 0.3327
0.0664 0.3086 0.3086
0.029 0.3097 0.4452
0.0823 0.3284 0.3412
0.0131 0.3135 0.313
0.0436 0.2919 0.2905
0.1155 0.3302 0.3302
0.1182 0.3802 0.3802
0.0055 0.4414 0.4414
0.1448 0.3401 0.3401
0.0997 0.3229 0.3216
0.1638 0.3298 0.3279
0.026 0.3395 0.3327
0.0505 0.2823 0.2804
0.0067 0.2803 0.2803
0.0118 0.2803 0.2803
0.075 0.2707 0.2705
0.0179 0.2803 0.2803
0.038 0.3215 0.2803
0.1214 0.3239 0.3194
0.0054 0.3687 0
0.0393 0.2618 0.2721
0.0797 0.265 0.2664
0.0436 0.2943 0.2969
0.0054 0.4934 0.4934
0.1189 0.2816 0.2815
0.019 0.2803 0.2803
0.0481 0.2975 0.3101
0.0553 0.2593 0.2998
0.0132 0.2951 0.2803
0.0956 0.2661 0.2829
0.0781 0.2685 0.2684
0.0072 0.2803 0.2803
0.0989 0.3235 0.323
0.076 0.2708 0.2708
0.1028 0.3244 0.3239
0.006 0.4546 0.4546
0.0092 0.2803 0.2803
0.1298 0.3226 0.3208
0.1002 0.3268 0.3267
0.037 0.2616 0.2716
0.0359 0.2794 0.2787
0.0753 0.2689 0.2679
0.126 0.3255 0.3245
0.031 0.3391 0.3391
0.0935 0.3143 0.3119
0.0823 0.3284 0.3412
0.1235 0.3348 0.3331
0.1364 0.3261 0.3255
0.0072 0.3043 0.3026
0.0146 0.2803 0.2803
0.0035 0.2545 0
0.128 0.3622 0.3622
0.0066 0.2763 0.2803
0.0272 0.2823 0.4456
0.0146 0.2803 0.2803
0.1235 0.3264 0.3252
0.0393 0.2907 0.2897
0.0443 0.4285 0.4748
0.0219 0.3039 0.2972
0.0146 0.3265 0.3102
0.0234 0.3218 0.3218
0.0134 0.2825 0.2825
0.0072 0.2523 0.2499
0.1248 0.3251 0.3244
0.0227 0.319 0.3
0.0134 0.2818 0.2818
0.0219 0.2724 0.292
0.0113 0.2649 0.2803
0.0106 0.3311 0.2803
0.0741 0.2708 0.2708
0.0073 0.253 0.2505
0.1435 0.3265 0.3246
0.0018 0.2763 0.2803
0.0846 0.2835 0.2834
0.0233 0.3321 0.3313
0.1323 0.3222 0.3205
0.0997 0.3229 0.3216
0.0823 0.3284 0.3412
0.0813 0.3128 0.3089
0.0911 0.3177 0.3121
0.0185 0.3402 0.34
0.1364 0.3261 0.3255
0.0074 0.274 0.1819
0.0701 0.3168 0.3158
0.1002 0.3198 0.3145
0.1088 0.3185 0.3149
0.3225 0.3019 0.3018
0.0213 0.3266 0.3073
0.3055 0.3016 0.3016
0.0267 0.2803 0.2803
0.0054 0.2941 0.4934
0.0348 0.2731 0
0.0196 0.2778 0.2706
0.0023 0.2586 0.1732
0.0464 0.4121 0.4532
0.0118 0.2979 0.2803
0.0074 0.3276 0
0.0053 0.3342 0
0.0904 0.3229 0.3194
0.009 0.2803 0.2803
0.1003 0.3162 0.3139
0.0067 0.2644 0.2478
0.1002 0.3268 0.3267
0.02 0.2685 0.2769
0.0224 0.2582 0.2224
0.0426 0.2915 0.2904
0.0524 0.2893 0.289
0.0776 0.2754 0.2745
0.128 0.3622 0.3622
0.0112 0.3268 0.2803
0.0323 0.3179 0.385
0.0219 0.2724 0.292
0.0136 0.2986 0.3038
0.0272 0.2823 0.4456
0.0375 0.2719 0.2719
0.0134 0.2807 0.2807
0.0047 0.2726 0.2726
0.0042 0.2731 0
0.0768 0.269 0.268
0.0491 0.265 0.3225
0.1046 0.3196 0.3169
0.0939 0.3168 0.315
0.0136 0.3372 0.2803
0.007 0.2803 0.2803
0.0154 0.2803 0.2803
0.3165 0.3032 0.3032
0.0574 0.3893 0.4181
0.1241 0.3227 0.3201
0.0936 0.3093 0.3678
0.1298 0.3226 0.3208
0.0191 0.2803 0.2803
0.0092 0.3276 0
0.0754 0.2633 0.2633
0.1448 0.3401 0.3401
0.0092 0.4278 0.4054
0.1225 0.3239 0.3215
0.0292 0.2952 0.444
0.0728 0.2842 0.2803
0.0278 0.3386 0.3386
0.1235 0.3348 0.3331
0.0872 0.3173 0.3114
0.0108 0.2731 0
0.0257 0.2565 0.2565
0.0302 0.2976 0.333
0.0935 0.3143 0.3119
0.0904 0.3229 0.3194
0.0943 0.2593 0.2727
0.0939 0.3168 0.315
0.0297 0.3312 0.3225

Assayability

Assay information

  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Trypanosoma cruzi ( 10 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    TcCLB.484299.10 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 3 )

Bibliographic References

124 literature references were collected for this gene.

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Gene identifier TcCLB.484299.10 (Trypanosoma cruzi), trypanothione reductase, putative
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