pI: 11.226 |
Length (AA): 58 |
MW (Da): 6773 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129106)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G24100 | hypothetical protein |
Arabidopsis thaliana | AT4G13615 | hypothetical protein |
Brugia malayi | Bm1_36260 | EDRK rich factor, identical |
Caenorhabditis elegans | CELE_Y37E3.4 | Protein MOAG-4 |
Dictyostelium discoideum | DDB_G0282301 | hypothetical protein |
Drosophila melanogaster | Dmel_CG17931 | CG17931 gene product from transcript CG17931-RD |
Echinococcus granulosus | EgrG_000711600 | Four F5 protein |
Entamoeba histolytica | EHI_013895 | 4F5 family protein |
Echinococcus multilocularis | EmuJ_000711600 | Four F5 protein |
Giardia lamblia | GL50803_25855 | Hypothetical protein |
Homo sapiens | ENSG00000172058 | small EDRK-rich factor 1A (telomeric) |
Homo sapiens | ENSG00000205572 | small EDRK-rich factor 1B (centromeric) |
Homo sapiens | 10169 | small EDRK-rich factor 2 |
Leishmania braziliensis | LbrM.01.0330 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_010300.1 | 4F5 protein family, putative |
Leishmania infantum | LinJ.01.0300 | hypothetical protein, conserved |
Leishmania major | LmjF.01.0300 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.01.0300 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_14601 | hypothetical protein |
Mus musculus | ENSMUSG00000021643 | small EDRK-rich factor 1 |
Oryza sativa | 4350379 | Os11g0425600 |
Oryza sativa | 4338762 | Os05g0407100 |
Onchocerca volvulus | OVOC1686 |
|
Saccharomyces cerevisiae | YDL085C-A | hypothetical protein |
Schistosoma japonicum | Sjp_0308960 | IPR007513,Four F5 protein,domain-containing |
Schistosoma japonicum | Sjp_0219440 | IPR007513,Four F5 protein,domain-containing |
Schistosoma mansoni | Smp_019420 | hypothetical protein |
Schmidtea mediterranea | mk4.006959.00 | |
Trypanosoma brucei gambiense | Tbg972.9.1650 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.9.3290 | 4F5 protein family, putative |
Trypanosoma cruzi | TcCLB.511577.104 | 4F5 protein family, putative |
Trypanosoma cruzi | TcCLB.504797.14 | 4F5 protein family, putative |
Trichomonas vaginalis | TVAG_218110 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_063180 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_300570 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.1980 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.1980 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.1980 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.1980 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.