Detailed view for TcCLB.507521.50

Basic information

TDR Targets ID: 52763
Trypanosoma cruzi, proteasome beta 6 subunit, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.601 | Length (AA): 246 | MW (Da): 27776 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00227   Proteasome subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0005839   proteasome core complex  
GO:0004298   threonine endopeptidase activity  
GO:0004175   endopeptidase activity  
GO:0051603   proteolysis involved in cellular protein catabolic process  

Metabolic Pathways

Proteasome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 234 1ryp (F) 2 219 16.00 0.013 1 1.07336 0.35
32 246 5le5 (L) 1 213 44.00 0 1 1.48588 -0.78
32 246 1ryp (M) 0 213 37.00 0 1 1.36488 -0.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127834)

Species Accession Gene Product
Arabidopsis thaliana AT3G60820   proteasome subunit beta type-1
Babesia bovis BBOV_II002710   proteasome A-type and B-type family protein
Brugia malayi Bm1_14125   proteasome subunit beta type 1
Candida albicans CaO19.2755   proteasome subunit
Candida albicans CaO19.10269   proteasome subunit
Caenorhabditis elegans CELE_C02F5.9   Protein PBS-6
Cryptosporidium hominis Chro.10279   proteasome subunit beta type 1 (20S proteasome alpha subunit F) (20S proteasome subunit beta-6)
Cryptosporidium parvum cgd1_2490   proteasome subunit beta type 1, putative
Dictyostelium discoideum DDB_G0272969   20S proteasome subunit beta-1
Drosophila melanogaster Dmel_CG4097   Proteasome beta6 subunit
Echinococcus granulosus EgrG_000252500   proteasome prosome macropain subunit beta
Entamoeba histolytica EHI_174670   proteasome subunit beta type 1, putative
Echinococcus multilocularis EmuJ_000252500   proteasome (prosome, macropain) subunit, beta
Giardia lamblia GL50803_13127   Proteasome subunit beta type 1
Homo sapiens ENSG00000008018   proteasome (prosome, macropain) subunit, beta type, 1
Leishmania braziliensis LbrM.06.0120   proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative
Leishmania donovani LdBPK_060140.1   proteasome beta 6 subunit, putative
Leishmania infantum LinJ.06.0140   proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative
Leishmania major LmjF.06.0140   proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative
Leishmania mexicana LmxM.06.0140   proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative
Loa Loa (eye worm) LOAG_00616   proteasome subunit beta type 1
Mus musculus ENSMUSG00000014769   proteasome (prosome, macropain) subunit, beta type 1
Neospora caninum NCLIV_042370   hypothetical protein
Oryza sativa 4347507   Os09g0505600
Oryza sativa 4346117   Os08g0529100
Plasmodium berghei PBANKA_1233100   proteasome subunit beta type-1, putative
Plasmodium falciparum PF3D7_0518300   proteasome subunit beta type-1, putative
Plasmodium knowlesi PKNH_1014900   proteasome subunit beta type-1, putative
Plasmodium vivax PVX_080330   proteasome subunit beta type-1, putative
Plasmodium yoelii PY02685   proteasome subunit beta type 1-related
Saccharomyces cerevisiae YBL041W   proteasome core particle subunit beta 6
Schistosoma japonicum Sjp_0090370   ko:K02732 20S proteasome subunit beta 6, putative
Schistosoma mansoni Smp_025800   proteasome subunit beta 1 (T01 family)
Schmidtea mediterranea mk4.000144.04   Proteasome subunit beta type-1
Trypanosoma brucei gambiense Tbg972.7.5470   proteasome beta 6 subunit,20S proteasome beta 6 subunit, putative
Trypanosoma brucei Tb11.v5.0162   proteasome beta 6 subunit
Trypanosoma congolense TcIL3000_7_3960   proteasome beta 6 subunit
Trypanosoma cruzi TcCLB.507521.50   proteasome beta 6 subunit, putative
Trypanosoma cruzi TcCLB.508577.160   proteasome beta 6 subunit, putative
Toxoplasma gondii TGME49_290005   proteasome subunit beta type 1, putative
Theileria parva TP04_0315   proteasome beat subunit, putative
Trichomonas vaginalis TVAG_152400   Family T1, proteasome beta subunit, threonine peptidase

Essentiality

TcCLB.507521.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.4790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.4790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.4790 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.4790 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C02F5.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_C02F5.9 Caenorhabditis elegans larval arrest wormbase
CELE_C02F5.9 Caenorhabditis elegans larval lethal wormbase
CELE_C02F5.9 Caenorhabditis elegans slow growth wormbase
CELE_C02F5.9 Caenorhabditis elegans sterile wormbase
YBL041W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1233100 Plasmodium berghei Essential plasmo
TGME49_290005 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 Compounds References
Saccharomyces cerevisiae proteasome core particle subunit beta 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.021 0.2806 0.7637
0.0077 0.2572 0.7224
0.1034 0.7143 0.7143
0.1062 0.6729 0.6723
0.0262 0.5699 0.5699
0.084 0.7708 0.7224
0.1034 0.7143 0.7143
0.0239 0.3082 0.2339
0.0309 0.7149 0.7149
0.0996 0.2792 0.7723
0.098 0.6073 0.773
0.0164 0.3994 0.5852
0.0426 0.3021 0.5421
0.1152 0.7747 0.7746
0.0066 0.3424 0.3424
0.0128 0.357 0.7224
0.0996 0.2792 0.7723
0.0517 0.3815 0.3815
0.0256 0.2513 0.7504
0.0126 0.4702 0
0.0386 0.7224 0.7224
0.021 0.2806 0.7637
0.0059 0.3603 0.5699
0.0836 0.7224 0.7224
0.0284 0.3994 0.5852
0.084 0.7708 0.7224
0.004 0.5699 0.5699
0.0164 0.3981 0.5839
0.0406 0.3964 0.3964
0.0063 0.3389 0.2777
0.0236 0.2651 0.2346
0.0064 0.486 1
0.0051 0.5699 0.5699
0.0252 0.4994 0.6062
0.0153 0.3483 0.2275
0.0252 0.4994 0.6062
0.0257 0.3597 0.723
0.0426 0.3021 0.5421
0.1034 0.7143 0.7143
0.0077 0.7224 0.7224
0.0859 0.7224 0.7224
0.0286 0.3204 0.633
0.1374 0.775 0.775
0.1016 0.7224 0.7224
0.0164 0.3981 0.5839
0.0077 0.5699 0.5699
0.0077 0.5699 0.5699
0.0434 0.565 0.6596
0.0269 0.3663 0.4811
0.0476 0.3246 0.7735
0.015 0.3968 0.3748
0.0966 0.7748 0.7748
0.0126 0.7224 0.7224
0.0727 0.3371 0.7168
0.0171 0.2669 0.2693
0.0164 0.3981 0.5839
0.0912 0.7518 0.7518
0.0071 0.7291 0.7224
0.0354 0.3061 0.7701
0.1034 0.7143 0.7143
0.0223 0.2502 0.5876
0.1034 0.7143 0.7143
0.0083 0.2632 0.2632
0.0426 0.3021 0.5421
0.098 0.6073 0.773
0.0449 0.7224 0.7224
0.0239 0.2747 0.3227
0.00829228 0.930345 0.930345
0.0076 0.2703 0.2365
0.0996 0.2792 0.7723
0.0138 0.3284 0.3284
0.0401 0.2708 0.7224
0.0907 0.7224 0.7224
0.0245 0.5896 0.5823
0.0304 0.398 0.5852
0.0996 0.2792 0.7723
0.033 0.2961 0.7224
0.0547 0.2961 0.3328
0.0349 0.3391 0.5699
0.0174 0.6916 0.5699
0.0099 0.3981 0.4492
0.1034 0.7143 0.7143
0.0996 0.2792 0.7723
0.0089 0.7733 0.7829
0.0347 0.373 0.4107
0.0504 0.2559 0.3097
0.1034 0.7143 0.7143
0.0391 0.4489 0.4266
0.0309 0.397 0.5852
0.0197 0.4468 0.7224
0.0059 0.7224 0.7224
0.0198 0.7224 0.7224
0.1097 0.7591 0.7586
0.0128 0.357 0.7224
0.1034 0.7143 0.7143
0.1034 0.7143 0.7143
0.0865 0.7224 0.7224
0.0928 0.5935 0.5935
0.0802 0.7224 0.7224
0.1374 0.775 0.775
0.0144 0.4166 0.4428
0.0996 0.2792 0.7723
0.1034 0.7143 0.7143
0.0448 0.7352 0.7224
0.0136 0.3301 0.5839
0.0301 0.7224 0.7224
0.0077 0.5699 0.5699
0.0077 0.5699 0.5699
0.0996 0.2792 0.7723
0.1034 0.7143 0.7143
0.0313 0.2526 0.7607
0.0235 0.2757 0.234
0.0441 0.4854 0.5959
0.1034 0.7143 0.7143
0.047 0.2606 0.77
0.1034 0.7143 0.7143
0.0037 0.5699 0.5699
0.0164 0.3994 0.5852
0.0077 0.7732 0.7732
0.0998 0.7678 0.7678
0.0554 0.2961 0.3325
0.0347 0.373 0.4107
0.0412 0.5221 0.5376
0.0077 0.3068 0.7506
0.021 0.2806 0.7637
0.0245 0.7324 0.7224
0.0218 0.38 0.38
0.0426 0.7224 0.7224
0.098 0.6073 0.773
0.0065 0.7224 0.7224
0.0168 0.2602 0.3238
0.1133 0.4964 0.4806
0.098 0.6073 0.773
0.0077 0.5699 0.5699
0.0065 0.7224 0.7224
0.0912 0.7518 0.7518
0.0127 0.5699 0.5699
0.0517 0.3815 0.3815
0.0059 0.3603 0.5699
0.0444 0.5402 0.5399
0.015 0.3981 0.5839
0.0132 0.3981 0.5839
0.0546 0.7015 0.7007
0.0301 0.4103 0.5852
0.0317 0.5971 0.5971
0.0423 0.7224 0.7224
0.150499 0.944554 0.944554
0.0062 0.5268 0.5699
0.004 0.5699 0.5699
0.0294 0.3994 0.5852
0.037 0.5304 0.55
0.0077 0.5699 0.5699
0.1034 0.7143 0.7143
0.0262 0.391 0.7384
0.0145 0.4405 0.7224
0.1034 0.7143 0.7143
0.035 0.4689 0.7638
0.0273 0.3994 0.5852
0.1034 0.7143 0.7143
0.1019 0.7715 0.7715
0.00829228 0.930345 0.930345
0.098 0.6073 0.773
0.0257 0.3597 0.723
0.0996 0.2792 0.7723
0.1034 0.7143 0.7143
0.0428 0.4084 0.5404
0.0164 0.3981 0.5839
0.0158 0.3971 0.5828
0.0141 0.4169 0.4401
0.0368 0.7351 0.7224
0.1058 0.7048 0.7048
0.1019 0.7715 0.7715
0.0066 0.3266 0.3793
0.0069 0.3918 0.3582
0.0241 0.2778 0.2382
0.0071 0.5699 0.5699
0.0891 0.5699 0.5699
0.0515 0.7159 0.7371
0.0257 0.3597 0.723
0.1034 0.7143 0.7143
0.092 0.7643 0.7643
0.0051 0.5699 0.5699
0.0902 0.7605 0.7224
0.1054 0.775 0.7745

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.507521.50 (Trypanosoma cruzi), proteasome beta 6 subunit, putative
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