Detailed view for PKNH_1332200

Basic information

TDR Targets ID: 529196
Plasmodium knowlesi, ABC transporter G family member 2, putative
Source Database / ID: 

pI: 8.9715 | Length (AA): 684 | MW (Da): 77882 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF01061   ABC-2 type transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 677 5do7 (B) 25 664 25.00 0 1 0.974463 0.86
46 275 6b89 (B) 3 226 21.00 0 1 0.627157 -0.64
47 264 3tif (A) 2 223 26.00 0 1 0.652613 -0.67
48 257 4q7l (C) 356 577 33.00 0.0000000000064 1 0.632418 0.08
62 681 5do7 (A) 67 648 23.00 0 1 1.02153 0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126574)

Species Accession Gene Product
Arabidopsis thaliana AT1G66950   ABC transporter G family member 39
Arabidopsis thaliana AT1G59870   ABC transporter G family member 36
Arabidopsis thaliana AT3G16340   p-coumaryl alcohol exporter
Arabidopsis thaliana AT2G36380   ABC transporter G family member 34
Arabidopsis thaliana AT2G01320   ABC transporter G family member 7
Arabidopsis thaliana AT4G15215   ABC transporter G family member 41
Arabidopsis thaliana AT2G29940   ABC transporter G family member 31
Arabidopsis thaliana AT4G15236   ABC transporter G family member 43
Arabidopsis thaliana AT3G30842   pleiotropic drug resistance 10
Arabidopsis thaliana AT2G37280   ABC transporter G family member 33
Arabidopsis thaliana AT3G53480   ABC transporter G family member 37
Arabidopsis thaliana AT2G26910   ABC transporter G family member 32
Arabidopsis thaliana AT4G15233   ABC transporter G family member 42
Arabidopsis thaliana AT1G31770   ABC transporter G family member 14
Arabidopsis thaliana AT1G15210   ABC transporter G family member 35
Arabidopsis thaliana AT4G27420   ABC transporter G family member 9
Arabidopsis thaliana AT4G15230   ABC transporter G family member 30
Arabidopsis thaliana AT1G15520   ABC transporter G family member 40
Brugia malayi Bm1_45725   ABC transporter family protein
Candida albicans CaO19.918   similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1
Candida albicans CaO19.12545   potential ABC transporter whose deletion does not affect fluconazole resistance
Candida albicans CaO19.5759   potential ABC family transporter similar to S. cerevisiae YNR070W
Candida albicans CaO19.5958   multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W)
Candida albicans CaO19.8533   similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1
Candida albicans CaO19.1312   N terminal 2/3 of Opaque-specific ABC transporter
Candida albicans CaO19.5079   potential ABC transporter whose deletion does not affect fluconazole resistance
Candida albicans CaO19.12006   potential ABC transporter similar to S. cerevisiae YOL075C
Candida albicans CaO19.10320   identical to C terminus of nonallelic CaP19.919
Candida albicans CaO19.6000   multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC
Candida albicans CaO19.13421   multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC
Candida albicans CaO19.919   similar to S. cerevisiae PDR5 (YOR153W)
Candida albicans CaO19.4531   potential ABC transporter similar to S. cerevisiae YOL075C
Candida albicans CaO19.13379   multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W)
Candida albicans CaO19.8534   similar to S. cerevisiae PDR5 (YOR153W)
Candida albicans CaO19.13182   potential ABC family transporter similar to S. cerevisiae YNR070W
Candida albicans CaO19.8892   N terminal 2/3 of Opaque-specific ABC transporter
Candida albicans CaO19.2802   identical to C terminus of nonallelic CaP19.919
Caenorhabditis elegans CELE_C10C6.5   Protein WHT-2
Caenorhabditis elegans CELE_C05D10.3   Protein WHT-1
Caenorhabditis elegans CELE_T26A5.1   Protein WHT-6
Caenorhabditis elegans CELE_F19B6.4   Protein WHT-5
Caenorhabditis elegans CELE_C16C10.12   Protein WHT-3
Caenorhabditis elegans CELE_Y47D3A.11   Protein WHT-8
Cryptosporidium hominis Chro.60627   ABC transporter protein
Cryptosporidium parvum cgd6_5450   ABC transporter, AAA domain
Dictyostelium discoideum DDB_G0269210   ABC transporter G family protein
Dictyostelium discoideum DDB_G0274117   ABC transporter G family protein
Dictyostelium discoideum DDB_G0281389   ABC transporter G family protein
Dictyostelium discoideum DDB_G0281391   ABC transporter G family protein
Dictyostelium discoideum DDB_G0269212   ABC transporter G family protein
Dictyostelium discoideum DDB_G0275687   ABC transporter G family protein
Dictyostelium discoideum DDB_G0289657   ABC transporter G family protein
Dictyostelium discoideum DDB_G0267432   ABC transporter G family protein
Dictyostelium discoideum DDB_G0289331   ABC transporter G family protein
Dictyostelium discoideum DDB_G0270826   ABC transporter G family protein
Dictyostelium discoideum DDB_G0274115   ABC transporter G family protein
Dictyostelium discoideum DDB_G0275689   ABC transporter G family protein
Dictyostelium discoideum DDB_G0273781   ABC transporter G family protein
Dictyostelium discoideum DDB_G0269208   ABC transporter G family protein
Dictyostelium discoideum DDB_G0287461   ABC transporter G family protein
Dictyostelium discoideum DDB_G0292986   ABC transporter G family protein
Dictyostelium discoideum DDB_G0273073   ABC transporter G family protein
Dictyostelium discoideum DDB_G0269206   ABC transporter G family protein
Dictyostelium discoideum DDB_G0293450   ABC transporter G family protein
Dictyostelium discoideum DDB_G0289655   ABC transporter G family protein
Drosophila melanogaster Dmel_CG5853   CG5853 gene product from transcript CG5853-RC
Drosophila melanogaster Dmel_CG2759   white
Echinococcus granulosus EgrG_000976200   ATP binding cassette sub family G
Echinococcus granulosus EgrG_001167900   ATP binding cassette sub family G
Echinococcus granulosus EgrG_000736700   ATP binding cassette sub family G
Entamoeba histolytica EHI_166890   ABC transporter, putative
Echinococcus multilocularis EmuJ_000736700   ATP binding cassette sub family G
Echinococcus multilocularis EmuJ_001167900   ATP binding cassette sub family G
Echinococcus multilocularis EmuJ_000976200   ATP binding cassette sub family G
Giardia lamblia GL50803_42048   ABC transporter
Homo sapiens ENSG00000160179   ATP-binding cassette, sub-family G (WHITE), member 1
Homo sapiens ENSG00000172350   ATP-binding cassette, sub-family G (WHITE), member 4
Homo sapiens ENSG00000118777   ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Homo sapiens ENSG00000143921   ATP-binding cassette, sub-family G (WHITE), member 8
Leishmania braziliensis LbrM.35.3110   ATP-binding cassette protein, putative
Leishmania braziliensis LbrM.15.0930   ABC transporter, putative
Leishmania donovani LdBPK_150950.1   ATP-binding cassette protein subfamily G, member 4, putative
Leishmania infantum LinJ.15.0950   ATP-binding cassette protein subfamily G, member 4, putative
Leishmania major LmjF.36.2890   ATP-binding cassette protein subfamily G, member 6, putative
Leishmania major LmjF.15.0890   ATP-binding cassette protein subfamily G, member 4, putative
Leishmania mexicana LmxM.15.0890   ABC transporter, putative
Loa Loa (eye worm) LOAG_11789   ABC transporter
Mus musculus ENSMUSG00000029299   ATP-binding cassette, sub-family G (WHITE), member 3
Mus musculus ENSMUSG00000029802   ATP-binding cassette, sub-family G (WHITE), member 2
Mus musculus 11307   ATP-binding cassette, sub-family G (WHITE), member 1
Mus musculus ENSMUSG00000032131   ATP-binding cassette, sub-family G (WHITE), member 4
Mus musculus ENSMUSG00000024254   ATP-binding cassette, sub-family G (WHITE), member 8
Mus musculus 102641203   ATP-binding cassette sub-family G member 4-like
Mycobacterium tuberculosis Rv1747   Probable conserved transmembrane ATP-binding protein ABC transporter
Mycobacterium ulcerans MUL_1237   transmembrane ABC transporter ATP-binding protein
Mycobacterium ulcerans MUL_3149   transmembrane ABC transporter ATP-binding protein
Mycobacterium ulcerans MUL_1424   transmembrane ABC transporter ATP-binding protein
Neospora caninum NCLIV_041710   hypothetical protein
Oryza sativa 9268766   Os09g0392400
Oryza sativa 4329158   Os02g0318500
Oryza sativa 9268453   Os02g0318600
Oryza sativa 9272130   Os01g0609066
Oryza sativa 9268937   Os02g0528900
Oryza sativa 4344750   Os08g0167000
Oryza sativa 4324722   Os01g0724500
Oryza sativa 9268322   Os12g0239950
Oryza sativa 9268454   Os01g0516800
Oryza sativa 4350807   Os11g0587600
Oryza sativa 4327727   Os01g0609200
Oryza sativa 4328687   Os02g0208300
Oryza sativa 4343412   Os07g0522500
Oryza sativa 4341281   Os06g0554800
Oryza sativa 4326812   Os01g0342700
Oryza sativa 4327730   Os01g0609900
Oryza sativa 4345450   Os08g0384500
Oryza sativa 4352332   Os12g0512700
Oryza sativa 4326045   Os01g0121700
Oryza sativa 4327728   Os01g0609300
Plasmodium berghei PBANKA_1018100   ABC transporter G family member 2, putative
Plasmodium falciparum PF3D7_1426500   ABC transporter G family member 2
Plasmodium knowlesi PKNH_1332200   ABC transporter G family member 2, putative
Plasmodium vivax PVX_085205   ABC transporter G family member 2, putative
Saccharomyces cerevisiae YOR153W   ATP-binding cassette multidrug transporter PDR5
Saccharomyces cerevisiae YDR406W   ATP-binding cassette multidrug transporter PDR15
Saccharomyces cerevisiae YIL013C   ATP-binding cassette multidrug transporter PDR11
Saccharomyces cerevisiae YOR328W   ATP-binding cassette multidrug transporter PDR10
Saccharomyces cerevisiae YDR011W   ATP-binding cassette transporter SNQ2
Saccharomyces cerevisiae YOL075C   hypothetical protein
Saccharomyces cerevisiae YOR011W   ATP-binding cassette sterol transporter AUS1
Saccharomyces cerevisiae YPL058C   ATP-binding cassette multidrug transporter PDR12
Saccharomyces cerevisiae YNR070W   ATP-binding cassette multidrug transporter PDR18
Schistosoma japonicum Sjp_0301010   ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative
Schistosoma japonicum Sjp_0034660   ATP-binding cassette sub-family G member 1, putative
Schistosoma mansoni Smp_137890   ATP-binding cassette sub-family g2 (white protein) (abcg2)
Schistosoma mansoni Smp_137880   hypothetical protein
Schistosoma mansoni Smp_181150   ABC transporter
Schmidtea mediterranea mk4.001601.01   ATP-binding cassette sub-family G member 2
Schmidtea mediterranea mk4.022140.01  
Schmidtea mediterranea mk4.033834.00  
Schmidtea mediterranea mk4.006642.01  
Schmidtea mediterranea mk4.004011.01  
Schmidtea mediterranea mk4.001145.00   ATP-binding cassette sub-family G member 2
Trypanosoma brucei gambiense Tbg972.10.9030   ATP-binding cassette protein, putative
Trypanosoma brucei gambiense Tbg972.9.3310   ABC transporter, putative
Trypanosoma brucei Tb927.9.6310   ABC transporter, putative
Trypanosoma brucei Tb927.10.7360   ATP-binding cassette protein, putative
Trypanosoma congolense TcIL3000_10_6340   ATP-binding cassette protein, putative
Trypanosoma congolense TcIL3000_9_2160   ABC transporter, putative
Trypanosoma cruzi TcCLB.506579.10   ABC transporter, putative
Trypanosoma cruzi TcCLB.507681.100   ATP-binding cassette protein, putative
Toxoplasma gondii TGME49_289350   ATP-binding cassette G family transporter ABCG84

Essentiality

PKNH_1332200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.7360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.7360 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.7360 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.4600 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4600 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.4600 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.160.4600 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C16C10.12 Caenorhabditis elegans larval arrest wormbase
CELE_C16C10.12 Caenorhabditis elegans larval lethal wormbase
PBANKA_1018100 Plasmodium berghei Slow plasmo
TGME49_289350 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Compounds References
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Compounds References
Saccharomyces cerevisiae ATP-binding cassette multidrug transporter PDR5 Compounds References
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PKNH_1332200 (Plasmodium knowlesi), ABC transporter G family member 2, putative
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