Detailed view for TcCLB.511867.140

Basic information

TDR Targets ID: 52987
Trypanosoma cruzi, Acyl carrier protein, mitochondrial, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 5.703 | Length (AA): 170 | MW (Da): 19124 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00550   Phosphopantetheine attachment site

Gene Ontology

Mouse over links to read term descriptions.
GO:0000036   acyl carrier activity  
GO:0048037   cofactor binding  
GO:0006633   fatty acid biosynthetic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
89 170 1klp (A) 3 84 27.00 0 1 0.98 -1.72
92 168 1t8k (A) 1 77 39.00 0 1 1.19 -3.09
93 164 1f80 (D) 2 73 46.00 0 1 1.24 -2.69
92 170 2m5r (A) 2 80 96.00 0 1 1.58601 -0.68
114 167 2qnw (A) 28 81 46.00 0.0059 1 1.03435 -1.66
129 164 1f80 (D) 38 73 56.00 0.0035 0.98 0.925465 -0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127028)

Species Accession Gene Product
Arabidopsis thaliana AT2G44620   acyl carrier protein 1
Arabidopsis thaliana AT1G65290   acyl carrier protein 2
Brugia malayi Bm1_19045   acyl carrier protein, mitochondrial precursor, putative
Candida albicans CaO19.2439   potential second version of mitochondrial acyl carrier protein more similar to N. crassa complex I 12 kD subunit
Candida albicans CaO19.9975   potential second version of mitochondrial acyl carrier protein more similar to N. crassa complex I 12 kD subunit
Candida albicans CaO19.819   similar to S. cerevisiae ACP1 (YKL192C) mitochondrial acyl carrier protein
Candida albicans CaO19.8439   similar to S. cerevisiae ACP1 (YKL192C) mitochondrial acyl carrier protein
Caenorhabditis elegans CELE_Y56A3A.19   Protein Y56A3A.19
Chlamydia trachomatis CT_236   acyl carrier protein
Dictyostelium discoideum DDB_G0291866   NADH dehydrogenase ubiquinone 1, alpha/beta subcomplex
Drosophila melanogaster Dmel_CG9160   mitochondrial acyl carrier protein 1
Escherichia coli b1094   acyl carrier protein (ACP)
Echinococcus granulosus EgrG_000581700   acyl carrier protein mitochondrial
Echinococcus granulosus EgrG_002014600   PP-binding domain containing protein
Echinococcus granulosus EgrG_002014700   PP-binding domain containing protein
Echinococcus multilocularis EmuJ_000581700   Acyl carrier protein, mitochondrial
Homo sapiens ENSG00000004779   NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
Leishmania braziliensis LbrM.27.0300   acyl carrier protein, putative
Leishmania donovani LdBPK_270300.1   Acyl carrier protein, mitochondrial, putative
Leishmania infantum LinJ.27.0300   acyl carrier protein, putative
Leishmania major LmjF.27.0290   acyl carrier protein, putative
Leishmania mexicana LmxM.27.0290   acyl carrier protein, putative
Loa Loa (eye worm) LOAG_06305   acyl carrier protein
Mycobacterium leprae ML1654   MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM
Mus musculus 70316   NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1
Mus musculus 102634451   predicted gene, 17257
Mycobacterium tuberculosis Rv2244   Meromycolate extension acyl carrier protein AcpM
Mycobacterium ulcerans MUL_1305   acyl carrier protein
Neospora caninum NCLIV_023990   Acyl carrier protein, related
Oryza sativa 4338621   Os05g0377000
Oryza sativa 4332854   Os03g0352800
Oryza sativa 4342743   Os07g0222800
Plasmodium berghei PBANKA_0305600   acyl carrier protein, putative
Plasmodium falciparum PF3D7_0208500   acyl carrier protein
Plasmodium knowlesi PKNH_0412600   acyl carrier protein, putative
Plasmodium vivax PVX_003880   acyl carrier protein, putative
Plasmodium yoelii PY04779   acyl carrier protein, putative
Saccharomyces cerevisiae YKL192C   Acp1p
Schistosoma japonicum Sjp_0206140   Acyl carrier protein, mitochondrial precursor, putative
Schistosoma mansoni Smp_015860   acyl carrier protein
Schmidtea mediterranea mk4.000417.00   Acyl carrier protein, mitochondrial
Schmidtea mediterranea mk4.000686.07   Acyl carrier protein, mitochondrial
Trypanosoma brucei gambiense Tbg972.3.490   acyl carrier protein, mitochondrial precursor, putative
Trypanosoma brucei Tb927.3.860   Acyl carrier protein, mitochondrial
Trypanosoma cruzi TcCLB.511867.140   Acyl carrier protein, mitochondrial, putative
Toxoplasma gondii TGME49_264080   acyl carrier protein ACP
Treponema pallidum TP0808   acyl carrier protein
Theileria parva TP02_0962   acyl carrier protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0738   acyl carrier protein

Essentiality

TcCLB.511867.140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.860 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.860 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.860 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.860 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1094 Escherichia coli essential goodall
CELE_Y56A3A.19 Caenorhabditis elegans larval arrest wormbase
CELE_Y56A3A.19 Caenorhabditis elegans slow growth wormbase
YKL192C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0305600 Plasmodium berghei Essential plasmo
TGME49_264080 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma brucei Acyl carrier protein, mitochondrial Compounds References
Homo sapiens NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.511867.140 (Trypanosoma cruzi), Acyl carrier protein, mitochondrial, putative
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