Detailed view for PKNH_0724000

Basic information

TDR Targets ID: 530600
Plasmodium knowlesi, protein kinase, putative
Source Database / ID: 

pI: 6.7194 | Length (AA): 3188 | MW (Da): 349046 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2711 3178 5mo4 (A) 112 514 20.00 0 1 -0.0113995 0.86
2722 2858 5gy2 (A) 316 460 17.00 0.39 0.05 0.0912737 -0.14
2894 3181 3soc (A) 195 484 25.00 0 1 0.300639 -0.31
2900 3107 5d1j (A) 11 197 40.00 0.0000005 1 0.0584447 0.82
2900 3108 1u59 (A) 347 534 29.00 0.000052 1 0.254758 0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129463)

Species Accession Gene Product
Arabidopsis thaliana AT5G62110   DNA-binding domain-containing protein
Babesia bovis BBOV_II006750   hypothetical protein
Babesia bovis BBOV_IV007830   serine/threonine protein kinase, putative
Babesia bovis BBOV_II003440   MIF4G domain containing protein
Brugia malayi Bm1_29405   hypothetical protein
Cryptosporidium hominis Chro.20247   hypothetical protein
Cryptosporidium hominis Chro.60196   MIF4G domain protein
Cryptosporidium parvum cgd2_2310   Ser/Thr protein kinase
Cryptosporidium parvum cgd6_1590   eukaryotic translation initiation factor 4 gamma; Nic domain containing protein
Loa Loa (eye worm) LOAG_08886   hypothetical protein
Neospora caninum NCLIV_031430   protein kinase, putative
Oryza sativa 9270578   Os01g0919300
Plasmodium berghei PBANKA_0902300   conserved Plasmodium protein, unknown function
Plasmodium berghei PBANKA_0110100   conserved Plasmodium protein, unknown function
Plasmodium berghei PBANKA_0939600   polyadenylate-binding protein-interacting protein 1, putative
Plasmodium berghei PBANKA_1415700   AP2 domain transcription factor, putative
Plasmodium berghei PBANKA_0826900   protein kinase, putative
Plasmodium berghei PBANKA_1437500   AP2 domain transcription factor AP2-G
Plasmodium berghei PBANKA_0912600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1107300   polyadenylate-binding protein-interacting protein 1, putative
Plasmodium falciparum PF3D7_1317200   AP2 domain transcription factor, putative
Plasmodium falciparum PF3D7_1136000   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0926100   protein kinase, putative
Plasmodium falciparum PF3D7_0105700   asparagine-rich antigen Pfa35-2
Plasmodium falciparum PF3D7_0611800   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1337500   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1222400   AP2 domain transcription factor
Plasmodium falciparum PF3D7_1222600   AP2 domain transcription factor AP2-G
Plasmodium falciparum PF3D7_1146800   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0904900   polyadenylate-binding protein-interacting protein 1, putative
Plasmodium knowlesi PKNH_0944600   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0934200   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1417900   AP2 domain transcription factor, putative
Plasmodium knowlesi PKNH_0724000   protein kinase, putative
Plasmodium knowlesi PKNH_1441700   AP2 domain transcription factor AP2-G, putative
Plasmodium vivax PVX_091040   polyadenylate-binding protein-interacting protein 1, putative
Plasmodium vivax PVX_099725   protein kinase, putative
Plasmodium vivax PVX_092415   hypothetical protein, conserved
Plasmodium vivax PVX_122680   transcription factor with AP2 domain(s), putative
Plasmodium vivax PVX_092935   hypothetical protein, conserved
Plasmodium vivax PVX_123760   transcription factor with AP2 domain(s), putative
Plasmodium yoelii PY01225   hypothetical protein
Plasmodium yoelii PY07205   hypothetical protein
Plasmodium yoelii PY03447   hypothetical protein
Plasmodium yoelii PY03626   ERYTHROCYTE MEMBRANE PROTEIN PFEMP3
Plasmodium yoelii PY00194   hypothetical protein
Plasmodium yoelii PY03053   hypothetical protein
Plasmodium yoelii PY07003   hypothetical protein
Plasmodium yoelii PY04926   hypothetical protein
Plasmodium yoelii PY00761   Protein kinase domain, putative
Plasmodium yoelii PY02775   hypothetical protein
Toxoplasma gondii TGME49_231070   protein kinase
Theileria parva TP04_0241   hypothetical protein
Theileria parva TP03_0296   hypothetical protein

Essentiality

PKNH_0724000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0110100 Plasmodium berghei Slow plasmo
PBANKA_0826900 Plasmodium berghei Essential plasmo
PBANKA_0902300 Plasmodium berghei Dispensable plasmo
PBANKA_0912600 Plasmodium berghei Dispensable plasmo
PBANKA_0939600 Plasmodium berghei Essential plasmo
PBANKA_1437500 Plasmodium berghei Fast plasmo
TGME49_231070 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cell division protein kinase 5 292 aa 24.6% 289 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 26.6% 177 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 19.2% 213 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.9% 309 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.4% 307 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PKNH_0724000 (Plasmodium knowlesi), protein kinase, putative
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