pI: 9.5722 |
Length (AA): 1009 |
MW (Da): 117246 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
23 | 201 | 1ej0 (A) | 30 | 207 | 33.00 | 0 | 1 | 0.568703 | -1.31 |
24 | 201 | 2nyu (A) | 2 | 187 | 28.00 | 0 | 1 | 0.402312 | -1.04 |
137 | 996 | 5nfv (A) | 36 | 981 | 24.00 | 0.72 | 1 | 0.717429 | 1.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126871)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G25730 | FtsJ-like methyltransferase family protein |
Babesia bovis | BBOV_III009210 | ribosomal RNA large subunit methyltransferase J family protein |
Babesia bovis | BBOV_II002180 | ribosomal RNA large subunit methyltransferase J protein, putative |
Brugia malayi | Bm1_19645 | ribosomal RNA methyltransferase |
Brugia malayi | Bm1_06985 | rRNA methyltransferase |
Candida albicans | CaO19.7601 | similar to S. cerevisiae MRM2 (YGL136C) mitochondrial rRNA methyltransferase |
Candida albicans | CaO19.7727 | potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase |
Candida albicans | CaO19.76 | potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase |
Caenorhabditis elegans | CELE_H06I04.3 | Protein H06I04.3, isoform B |
Cryptosporidium hominis | Chro.40181 | FtsJ cell division protein |
Cryptosporidium parvum | cgd4_1580 | Spb1p-like, FtsJ methylase |
Dictyostelium discoideum | DDB_G0284945 | rRNA methyltransferase |
Drosophila melanogaster | Dmel_CG8939 | CG8939 gene product from transcript CG8939-RA |
Drosophila melanogaster | Dmel_CG11447 | CG11447 gene product from transcript CG11447-RA |
Escherichia coli | b3179 | 23S rRNA U2552 2'-O-ribose methyltransferase, SAM-dependent |
Echinococcus granulosus | EgrG_000874050 | putative ribosomal RNA methyltransferase/cell division FtsJ protein |
Echinococcus granulosus | EgrG_000251100 | rrna methyltransferase 3 |
Entamoeba histolytica | EHI_088070 | ribosomal RNA methyltransferase, putative |
Echinococcus multilocularis | EmuJ_000874050 | ribosomal RNA large subunit methyltransferase |
Echinococcus multilocularis | EmuJ_000251100 | rrna methyltransferase 3 |
Giardia lamblia | GL50803_16993 | FtsJ cell division protein, putative |
Homo sapiens | ENSG00000122687 | FtsJ RNA methyltransferase homolog 2 (E. coli) |
Homo sapiens | ENSG00000108592 | FtsJ homolog 3 (E. coli) |
Leishmania braziliensis | LbrM.27.2160 | FtsJ cell division protein, putative |
Leishmania donovani | LdBPK_271900.1 | FtsJ cell division protein, putative |
Leishmania infantum | LinJ.27.1900 | FtsJ cell division protein, putative |
Leishmania mexicana | LmxM.27.1980 | FtsJ cell division protein, putative |
Loa Loa (eye worm) | LOAG_07721 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14905 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05438 | ribosomal RNA methyltransferase |
Mus musculus | ENSMUSG00000020706 | FtsJ homolog 3 (E. coli) |
Mus musculus | ENSMUSG00000029557 | FtsJ homolog 2 (E. coli) |
Neospora caninum | NCLIV_004720 | ribosomal RNA large subunit methyltransferase J, putative |
Neospora caninum | NCLIV_002910 | ftsJ-like methyltransferase domain-containing protein, putative |
Oryza sativa | 4339641 | Os05g0567400 |
Onchocerca volvulus | OVOC9451 | Putative ribosomal RNA methyltransferase |
Plasmodium berghei | PBANKA_1130900 | large subunit rRNA methyltransferase, putative |
Plasmodium berghei | PBANKA_1408100 | ribosomal RNA methyltransferase, putative |
Plasmodium falciparum | PF3D7_1354300 | large subunit rRNA methyltransferase, putative |
Plasmodium falciparum | PF3D7_1309600 | ribosomal RNA methyltransferase, putative |
Plasmodium knowlesi | PKNH_1410000 | ribosomal RNA methyltransferase, putative |
Plasmodium knowlesi | PKNH_1117500 | large subunit rRNA methyltransferase, putative |
Plasmodium vivax | PVX_122310 | ribosomal RNA large subunit methyltransferase J, putative |
Plasmodium vivax | PVX_114700 | FtsJ-like methyltransferase, putative |
Plasmodium yoelii | PY02347 | FtsJ cell division protein, putative |
Plasmodium yoelii | PY05898 | FtsJ cell division protein |
Plasmodium yoelii | PY03106 | FtsJ cell division protein, putative |
Saccharomyces cerevisiae | YCL054W | Spb1p |
Saccharomyces cerevisiae | YGL136C | Mrm2p |
Schistosoma japonicum | Sjp_0064940 | ko:K00599 rRNA methyltransferase Spb1 [EC:2.1.1.-], putative |
Schistosoma japonicum | Sjp_0035560 | ko:K02427 cell division protein methyltransferase FtsJ, putative |
Schistosoma japonicum | Sjp_0219450 | expressed protein |
Schistosoma japonicum | Sjp_0064910 | Putative rRNA methyltransferase 3, putative |
Schistosoma mansoni | Smp_045040 | ribosomal RNA methyltransferase |
Schistosoma mansoni | Smp_148920 | cell division protein ftsj |
Schmidtea mediterranea | mk4.001938.05 | pre-rRNA processing protein FTSJ3 |
Schmidtea mediterranea | mk4.004956.00 | pre-rRNA processing protein FTSJ3 |
Schmidtea mediterranea | mk4.002622.05 | Putative ribosomal RNA methyltransferase |
Schmidtea mediterranea | mk4.001938.04 | pre-rRNA processing protein FTSJ3 |
Trypanosoma brucei gambiense | Tbg.972.2.2600 | FtsJ cell division protein, putative |
Trypanosoma brucei | Tb927.2.4550 | 2'-O-ribose RNA methyltransferase SPB1 homolog |
Trypanosoma congolense | TcIL3000_0_06130 | FtsJ cell division protein, putative |
Trypanosoma congolense | TcIL3000_2_900 | FtsJ cell division protein, putative |
Toxoplasma gondii | TGME49_207990 | ribosomal RNA large subunit methyltransferase J protein |
Toxoplasma gondii | TGME49_220940 | ribosomal RNA methyltransferase (FtsJ) family protein |
Treponema pallidum | TP0682 | cell division protein (ftsJ) |
Theileria parva | TP04_0351 | ribosomal RNA methyltransferase, putative |
Theileria parva | TP04_0831 | rRNA methyltransferase, putative |
Trichomonas vaginalis | TVAG_309050 | ribosomal RNA methyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.4550 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.4550 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.4550 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.4550 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3179 | Escherichia coli | essential | goodall |
CELE_H06I04.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H06I04.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H06I04.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_H06I04.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H06I04.3 | Caenorhabditis elegans | sterile | wormbase |
YCL054W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1130900 | Plasmodium berghei | Essential | plasmo |
PBANKA_1408100 | Plasmodium berghei | Essential | plasmo |
TGME49_207990 | Toxoplasma gondii | Probably essential | sidik |
TGME49_220940 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) | Dengue virus type 2 NS3 protein | Compounds | References |
Dengue virus 2 | Genome polyprotein | Compounds | References |