Detailed view for TcCLB.505183.80

Basic information

TDR Targets ID: 53368
Trypanosoma cruzi, signal recognition particle, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.8446 | Length (AA): 487 | MW (Da): 53451 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00448   SRP54-type protein, GTPase domain
PF02881   SRP54-type protein, helical bundle domain
PF02978   Signal peptide binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0048500   signal recognition particle  
GO:0005515   protein binding  
GO:0003924   GTPase activity  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0008312   7S RNA binding  
GO:0005525   GTP binding  
GO:0006614   SRP-dependent cotranslational protein targeting to membrane  

Metabolic Pathways

Protein export (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 86 1wgw (A) 8 90 41.00 0.00000005 1 0.84 -1.88
5 432 2ffh (A) 4 418 33.00 0 1 1.34 -0.98
8 431 1qzx (A) 3 432 35.00 0 1 1.37 -1.1
1 436 3dm5 (A) 1 435 43.00 0 1 1.42678 -0.6
3 438 3ndb (B) 2 447 40.00 0 1 1.34878 -0.56
24 296 5l3q (A) 24 296 62.00 0 1 1.39807 -1.56
317 469 4xco (C) 316 473 30.00 0 0.92 0.635668 -0.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126863)

Species Accession Gene Product
Arabidopsis thaliana AT5G03940   chloroplast signal recognition particle 54
Arabidopsis thaliana AT1G15310   signal recognition particle protein SRP54A
Arabidopsis thaliana AT1G48900   signal recognition particle subunit SRP54
Arabidopsis thaliana AT5G49500   Signal recognition particle SRP54 subunit protein
Babesia bovis BBOV_IV009210   signal recognition particle SRP54 protein, putative
Brugia malayi Bm1_17780   signal recognition particle 54 kDa protein (SRP54), putative
Candida albicans CaO19.3243   Signal recognition particle subunit
Candida albicans CaO19.10753   Signal recognition particle subunit
Caenorhabditis elegans CELE_F21D5.7   Protein F21D5.7
Cryptosporidium hominis Chro.70193   signal recognition particle protein SRP54
Cryptosporidium parvum cgd7_1640   SRP54. signal recognition 54. GTpase.
Chlamydia trachomatis CT_025   signal recognition particle GTPase
Dictyostelium discoideum DDB_G0275455   signal recognition particle 54 kDa subunit
Drosophila melanogaster Dmel_CG4659   Signal recognition particle protein 54k
Escherichia coli b2610   Signal Recognition Particle (SRP) component with 4.5S RNA (ffs)
Echinococcus granulosus EgrG_000163100   signal recognition particle 54 kda protein
Entamoeba histolytica EHI_004750   signal recognition particle protein SRP54, putative
Echinococcus multilocularis EmuJ_000163100   signal recognition particle 54 kda protein
Giardia lamblia GL50803_15156   SRP GTPase
Homo sapiens ENSG00000100883   signal recognition particle 54kDa
Leishmania braziliensis LbrM.24.0740   signal recognition particle, putative
Leishmania donovani LdBPK_240740.1   signal recognition particle, putative
Leishmania infantum LinJ.24.0740   signal recognition particle, putative
Leishmania major LmjF.24.0730   signal recognition particle, putative
Leishmania mexicana LmxM.24.0730   signal recognition particle, putative
Loa Loa (eye worm) LOAG_06790   signal recognition particle protein
Mycobacterium leprae ML1622c   PROBABLE SIGNAL RECOGNITION PARTICLE PROTEIN FFH (FIFTY-FOUR HOMOLOG) (SRP PROTEIN)
Mus musculus ENSMUSG00000079108   signal recognition particle 54B
Mus musculus 24067   signal recognition particle 54A
Mus musculus ENSMUSG00000079108   signal recognition particle 54C
Mycobacterium tuberculosis Rv2916c   Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein)
Mycobacterium ulcerans MUL_2040   signal recognition particle protein Ffh
Neospora caninum NCLIV_056440   Signal recognition particle GTPase, related
Oryza sativa 4324712   Os01g0772800
Oryza sativa 9267495   Os11g0153600
Oryza sativa 4349809   Os11g0153700
Oryza sativa 4339274   Os05g0509500
Onchocerca volvulus OVOC7330   Signal recognition particle 54 kDa protein homolog
Plasmodium berghei PBANKA_1313800   signal recognition particle subunit SRP54, putative
Plasmodium falciparum PF3D7_1450100   signal recognition particle subunit SRP54
Plasmodium knowlesi PKNH_1232000   signal recognition particle subunit SRP54, putative
Plasmodium vivax PVX_117980   signal recognition particle subunit SRP54, putative
Plasmodium yoelii PY06341   signal recognition particle protein SRP54
Saccharomyces cerevisiae YPR088C   Srp54p
Schistosoma japonicum Sjp_0079590   ko:K03106 signal recognition particle, subunit SRP54, putative
Schistosoma japonicum Sjp_0112730   similar to Signal recognition particle 54 kDa protein, putative
Schistosoma mansoni Smp_059540   signal recognition particle 54 kD protein
Schmidtea mediterranea mk4.034628.01   Signal recognition particle 54 kDa protein
Schmidtea mediterranea mk4.002132.04   Putative signal recognition particle 54 kD protein
Trypanosoma brucei gambiense Tbg972.11.6090   signal recognition particle 54 kDa, putative
Trypanosoma brucei Tb927.11.5400   signal recognition particle 54 kDa
Trypanosoma congolense TcIL3000.11.5640   signal recognition particle 54 kDa
Trypanosoma cruzi TcCLB.505183.80   signal recognition particle, putative
Toxoplasma gondii TGME49_313100   signal recognition particle SRP54 protein
Treponema pallidum TP0416   signal recognition particle protein (ffh)
Theileria parva TP01_0852   signal recognition particle 54 kDa protein, putative
Trichomonas vaginalis TVAG_335890   signal recognition particle receptor alpha subunit, putative
Trichomonas vaginalis TVAG_028560   signal recognition particle protein, putative
Trichomonas vaginalis TVAG_027020   cell division protein ftsy, putative
Wolbachia endosymbiont of Brugia malayi Wbm0049   Signal recognition particle GTPase

Essentiality

TcCLB.505183.80 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3070 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.3070 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.3070 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.02.3070 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b2610 Escherichia coli essential goodall
CELE_F21D5.7 Caenorhabditis elegans larval lethal wormbase
CELE_F21D5.7 Caenorhabditis elegans sterile wormbase
YPR088C Saccharomyces cerevisiae inviable yeastgenome
TGME49_313100 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.505183.80 (Trypanosoma cruzi), signal recognition particle, putative
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