Detailed view for TcCLB.511911.120

Basic information

TDR Targets ID: 53393
Trypanosoma cruzi, DNA polymerase eta, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 8.0116 | Length (AA): 503 | MW (Da): 56081 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00817   impB/mucB/samB family

Gene Ontology

Mouse over links to read term descriptions.
GO:0003887   DNA-directed DNA polymerase activity  
GO:0003684   damaged DNA binding  
GO:0006281   DNA repair  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 438 1jih (A) 23 507 24.00 0 1 1.03 -0.23
330 448 1unn (C) 242 350 17.00 0 0.36 0.39 -1.07
2 438 4j9o (A) 7 430 27.00 0 1 1.10469 0.15
4 94 4f4w (A) 3 99 22.00 0 0.4 0.387815 -0.59
4 270 4f4w (A) 3 188 33.00 0.000013 0.97 0.295815 1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128521)

Species Accession Gene Product
Arabidopsis thaliana AT5G44740   Y-family DNA polymerase H
Brugia malayi Bm1_21045   ImpB/MucB/SamB family protein
Candida albicans CaO19.866   similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions
Candida albicans CaO19.8485   similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions
Caenorhabditis elegans CELE_F53A3.2   Protein POLH-1
Cryptosporidium parvum cgd4_3920   DinB/family X-type DNA polymerase
Drosophila melanogaster Dmel_CG7143   CG7143 gene product from transcript CG7143-RA
Echinococcus granulosus EgrG_001106600   dna polymerase eta
Echinococcus multilocularis EmuJ_001106600   dna polymerase eta
Homo sapiens ENSG00000170734   polymerase (DNA directed), eta
Leishmania braziliensis LbrM.21.0680   DNA polymerase eta, putative
Leishmania braziliensis LbrM.21.0690   DNA polymerase eta, putative
Leishmania infantum LinJ.21.0680   DNA polymerase eta, putative
Leishmania infantum LinJ.21.0690   DNA polymerase eta, putative
Leishmania major LmjF.21.0630   DNA polymerase eta, putative
Leishmania major LmjF.21.0620   DNA polymerase eta, putative
Leishmania mexicana LmxM.21.0630  
Leishmania mexicana LmxM.21.0620   DNA polymerase eta, putative
Loa Loa (eye worm) LOAG_06542   hypothetical protein
Mus musculus ENSMUSG00000023953   polymerase (DNA directed), eta (RAD 30 related)
Neospora caninum NCLIV_042210   Pc21g17280 protein, related
Oryza sativa 4325305   Os01g0757800
Saccharomyces cerevisiae YDR419W   Rad30p
Schistosoma japonicum Sjp_0072790   ko:K03509 DNA polymerase eta subunit, putative
Schistosoma japonicum Sjp_0116210   ko:K03509 DNA polymerase eta subunit, putative
Schistosoma mansoni Smp_136180   DNA polymerase eta
Schmidtea mediterranea mk4.000539.14  
Trypanosoma brucei gambiense Tbg972.10.2030   DNA polymerase eta, putative
Trypanosoma brucei Tb927.10.1710   DNA polymerase eta, putative
Trypanosoma congolense TcIL3000_10_1450   DNA polymerase eta, putative
Trypanosoma cruzi TcCLB.511911.120   DNA polymerase eta, putative
Trypanosoma cruzi TcCLB.508637.79   DNA polymerase eta, putative
Toxoplasma gondii TGME49_234580   ImpB/MucB/SamB family protein

Essentiality

TcCLB.511911.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1710 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1710 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.1710 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_234580 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens polymerase (DNA directed), eta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0045 0.3547 0.2178
0.0041 0.3022 0.2827
0.0073 0.2999 0.4805
0.0302 0.3511 0.6232
0.0038 0.5907 0.5888
0.0033 0.4775 0.4775
0.0034 0.4604 0.4775
0.0109 0.2906 0.688
0.0117 0.264 0.346
0.0038 0.5809 0.4874
0.0038 0.3228 0.4775
0.0038 0.3628 0.4775
0.0045 0.357 0
0.0038 0.4871 0.6568
0.0038 0.4814 0.6568
0.0032 0.5597 0.4775
0.0038 0.4874 0.4874
0.0038 0.577 0.4775
0.0038 0.6522 0.6522
0.0244 0.2966 0.539
0.003 0.4775 0.4775
0.0038 0.6161 0.4775
0.004 0.3414 0.2113
0.0037 0.3583 0.4848
0.0038 0.6161 0.4775
0.0038 0.3184 0.3184
0.0038 0.648 0.648
0.0031 0.449 0.6568
0.0038 0.5408 0.4775
0.0032 0.528 0.4775
0.0038 0.4775 0.4775
0.0038 0.577 0.4775
0.0032 0.5618 0.4775
0.0038 0.5597 0.4775
0.0032 0.5597 0.4775
0.0033 0.4775 0.4775
0.004 0.4851 0.4851
0.0036 0.4393 0.4393
0.0045 0.5103 0.5068
0.0031 0.4775 0.4775
0.0038 0.533 0.4775
0.0062 0.2958 0.4726
0.0032 0.3434 0.2507
0.0036 0.3798 0.3461
0.0038 0.5103 0.5068
0.0033 0.4775 0.4775
0.0038 0.2708 0.5484
0.0033 0.533 0.4874
0.0035 0.6422 0.4775
0.0031 0.533 0.4775
0.0038 0.6264 0.5965
0.0038 0.6568 0.6568
0.0069 0.5115 0.4749
0.0031 0.4775 0.4775
0.0038 0.4775 0.4775
0.0038 0.4871 0.6568
0.0038 0.4604 0.4775
0.0033 0.5597 0.4775
0.0031 0.533 0.4775
0.0032 0.533 0.4775
0.0044 0.3608 0.489
0.0038 0.4814 0.6568
0.0034 0.4775 0.4775
0.0036 0.2562 0.4819
0.0116 0.2782 0.2985
0.0038 0.4968 0.4775
0.0029 0.3596 0.3128
0.0038 0.5597 0.4874
0.0038 0.5611 0.4775
0.0038 0.5637 0.4775
0.0068 0.6128 0.5853
0.0128 0.372 0.5317
0.0034 0.5597 0.4775
0.0031 0.3694 0.3128
0.0038 0.3628 0.4775
0.0045 0.4787 0
0.0038 0.4775 0.4775
0.0038 0.577 0.4775
0.0061 0.2707 0.5246
0.0039 0.3162 0.2263
0.0038 0.5597 0.4775
0.0171 0.2606 0.4713
0.0113 0.2901 0.2867
0.0038 0.533 0.4775
0.0038 0.4604 0.4775
0.0033 0.5597 0.4775
0.008 0.3725 0.4122
0.003 0.4524 0.4775
0.0033 0.533 0.4775
0.0035 0.4654 0.6568
0.0033 0.4775 0.4775
0.0033 0.2716 0.1999
0.0099 0.2864 0.677
0.0038 0.2911 0.4775
0.0038 0.3843 0.3843
0.0038 0.6161 0.4775
0.0038 0.4775 0.4775
0.0038 0.5809 0.4775
0.0038 0.414 0.414
0.0032 0.533 0.4775
0.0033 0.4717 0.4775
0.0038 0.4775 0.4775
0.0045 0.489 0.489
0.0038 0.577 0.4775
0.0031 0.2805 0.6568
0.0351 0.2685 0.3366
0.0043 0.2575 0.2966
0.0032 0.5037 0.5037
0.0038 0.4519 0.4874
0.0067 0.3871 0.6568
0.0031 0.577 0.4775
0.0038 0.3982 0.4775
0.0032 0.533 0.4775
0.0037 0.3583 0.4848
0.0038 0.648 0.648
0.0038 0.6422 0.4775
0.0034 0.6161 0.4775
0.0141 0.2906 0.4199
0.0099 0.4098 0.6329
0.0038 0.2911 0.4775
0.0038 0.5888 0.5888
0.0038 0.2549 0.4775
0.0038 0.533 0.4775
0.0182 0.327 0.5254
0.0034 0.5597 0.4874
0.003 0.577 0.4775
0.0035 0.533 0.4775
0.0038 0.577 0.4775
0.0038 0.2623 0.3128
0.0038 0.414 0.414
0.0034 0.5597 0.4775
0.0035 0.5597 0.5092
0.0038 0.3982 0.4775
0.0038 0.5597 0.4775
0.0037 0.3413 0.3413
0.0038 0.577 0.4775
0.0038 0.6318 0.648
0.0031 0.4775 0.4775
0.0038 0.4956 0.4956
0.0031 0.533 0.4775
0.0036 0.4775 0.4775
0.0033 0.3434 0.4775
0.0036 0.4775 0.4775
0.0031 0.533 0.4775
0.0044 0.4145 0
0.0033 0.577 0.4775
0.0038 0.2762 0.4775
0.0031 0.4465 0.6568
0.0032 0.3286 0.247
0.0139 0.442 0.6103
0.0038 0.4775 0.4775
0.0049 0.3007 0.3007
0.0038 0.3082 0
0.0033 0.533 0.4775
0.0038 0.5373 0.4775
0.0038 0.5597 0.4775
0.0062 0.5219 0.4775
0.0038 0.577 0.4775
0.0038 0.5597 0.4775
0.0062 0.2958 0.4726
0.0041 0.2956 0.2827
0.0031 0.4775 0.4775
0.0021 0.2937 0.4775
0.0034 0.262 0.4874
0.0034 0.4775 0.4775
0.0031 0.6408 0.6568
0.0031 0.533 0.4775
0.0038 0.577 0.4775
0.0032 0.5597 0.4775
0.0111 0.5203 0.6336
0.0038 0.5597 0.4775
0.0038 0.5597 0.4775
0.0031 0.6408 0.6568
0.0038 0.648 0.648
0.0035 0.4775 0.4775
0.0045 0.4848 0.4848
0.0106 0.2964 0.4344
0.0126 0.3719 0.5187
0.0038 0.4654 0.6568
0.0135 0.2593 0.3797
0.0035 0.5597 0.4775
0.0038 0.5597 0.4775
0.0038 0.577 0.5406
0.0038 0.533 0.4775
0.0032 0.3982 0.4775
0.0038 0.46 0.4775
0.0197 0.2736 0.5594
0.0033 0.272 0.272
0.0038 0.2762 0.4775
0.0038 0.2869 0.5888
0.0038 0.3829 0.4775
0.003 0.3469 0.3469
0.0033 0.6418 0.6568
0.0045 0.5067 0.489
0.0183 0.2753 0.3664
0.0043 0.4393 0.4393
0.0038 0.5888 0.5888
0.0038 0.5597 0.4775
0.0038 0.4238 0.4943
0.0035 0.4791 0.4947
0.0038 0.577 0.4775
0.0038 0.5597 0.4775
0.0034 0.6422 0.4775
0.0036 0.4393 0.4393
0.0038 0.5907 0.5888
0.0032 0.398 0.6568
0.0134 0.4177 0.6718
0.0045 0.495 0.489
0.0038 0.2586 0.4775
0.0037 0.2562 0.5951
0.0019 0.4775 0.4775
0.0038 0.5597 0.4874
0.0038 0.5155 0.4775
0.0038 0.3982 0.4775
0.0045 0.489 0.489
0.0051 0.292 0.3063
0.0038 0.4871 0.6568
0.0038 0.533 0.4775
0.0038 0.5611 0.4775
0.0038 0.5736 0.5888
0.003 0.46 0.4775
0.0037 0.5597 0.4775
0.0038 0.6006 0.4775
0.01 0.3837 0.6879
0.0038 0.577 0.4775
0.0038 0.5373 0.5406
0.0038 0.2937 0.4775
0.0038 0.2604 0.2604
0.0141 0.2988 0.4397
0.0038 0.577 0.4775
0.0038 0.3628 0.4874
0.0034 0.5597 0.4775
0.0035 0.533 0.4775
0.0032 0.533 0.4775
0.0038 0.4524 0.4775
0.0033 0.533 0.4775
0.0038 0.533 0.4775
0.0067 0.2517 0.2349
0.0031 0.577 0.4775
0.003 0.533 0.4775
0.0038 0.5597 0.4775
0.0038 0.4524 0.4775
0.0038 0.533 0.4775
0.0031 0.4465 0.6568
0.0031 0.6422 0.4775
0.0031 0.3896 0.4775
0.0038 0.2537 0
0.0038 0.46 0.4775
0.0045 0.2848 0.489
0.003 0.5597 0.4775
0.0038 0.46 0.4775
0.0038 0.2635 0.4775
0.0038 0.2937 0.4775
0.0038 0.6023 0.4775
0.0037 0.2893 0.1538
0.0036 0.5739 0.5488
0.0114 0.3156 0.5531
0.0038 0.4968 0.4775
0.0034 0.4524 0.4775
0.0038 0.379 0
0.0037 0.5101 0.4775
0.0071 0.4698 0.6009
0.0034 0.4775 0.4775
0.0038 0.6161 0.4775
0.0038 0.533 0.4775
0.0045 0.489 0.489
0.0038 0.4775 0.4775
0.0108 0.3341 0.3341
0.0037 0.4775 0.4775
0.0031 0.533 0.4775
0.0038 0.2937 0.4775
0.0035 0.3246 0.4775
0.0099 0.2864 0.677
0.0038 0.648 0.648
0.0031 0.5597 0.4775
0.0032 0.6161 0.4775
0.0038 0.3982 0.4775
0.0128 0.2528 0.3178
0.0031 0.5478 0.4775
0.0031 0.3518 0.4775
0.0038 0.5597 0.4775
0.0038 0.577 0.5322
0.0038 0.4874 0.4874
0.0038 0.3982 0.4775
0.0038 0.3628 0.4775
0.0038 0.5584 0.4775
0.0038 0.3829 0.4874
0.0038 0.6161 0.4775
0.0032 0.3829 0.4775
0.0038 0.5888 0.5888
0.0031 0.533 0.4775
0.0032 0.6161 0.4775
0.0045 0.2893 0.1538
0.0032 0.533 0.4775
0.0033 0.5597 0.4775
0.0036 0.2554 0.5988
0.0038 0.2937 0.4775
0.0038 0.5597 0.4775
0.0036 0.3017 0
0.0111 0.287 0.33
0.0035 0.577 0.4775
0.0038 0.5809 0.4775
0.0038 0.6408 0.6568
0.0031 0.2762 0.4775
0.0038 0.3982 0.4775
0.0045 0.3569 0.4848
0.0038 0.3982 0.4775
0.0038 0.533 0.4775
0.0038 0.4604 0.4775
0.0036 0.464 0.1385
0.0031 0.648 0.648
0.0137 0.2857 0.4968
0.0038 0.2842 0.4874
0.0038 0.5597 0.4775
0.0031 0.2549 0.5401
0.0045 0.497 0.4714
0.0038 0.4524 0.4775
0.01 0.3837 0.6879
0.0038 0.3829 0.4874
0.0062 0.2958 0.4726
0.0038 0.5597 0.4775
0.0038 0.275 0.4775
0.0062 0.2958 0.4726

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511911.120 (Trypanosoma cruzi), DNA polymerase eta, putative
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