Detailed view for PY07326

Basic information

TDR Targets ID: 535377
Plasmodium yoelii, DNA gyrase subunit a-related
Source Database / ID: 

pI: 9.1414 | Length (AA): 968 | MW (Da): 112917 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00521   DNA gyrase/topoisomerase IV, subunit A

Gene Ontology

Mouse over links to read term descriptions.
GO:0003918   DNA topoisomerase (ATP-hydrolyzing) activity  
GO:0005524   ATP binding  
GO:0003677   DNA binding  
GO:0006265   DNA topological change  
GO:0006259   DNA metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
95 920 5xwp (A) 63 937 24.00 0.0099 1 0.779806 1.44
193 697 4z2c (A) 12 485 35.00 0 1 0.926194 -0.2
210 696 4ddq (A) 32 487 36.00 0 1 0.900599 -0.13
753 932 4aly (A) 94 301 17.00 0 0.26 0.18925 -1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129568)

Species Accession Gene Product
Arabidopsis thaliana AT3G10690   DNA gyrase subunit A
Babesia bovis BBOV_IV003640   DNA gyrase A subunit, putative
Chlamydia trachomatis CT_189   DNA gyrase subunit A
Escherichia coli b2231   DNA gyrase (type II topoisomerase), subunit A
Mycobacterium leprae ML0006   Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)
Mycobacterium tuberculosis Rv0006   DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)
Mycobacterium ulcerans MUL_0006   DNA gyrase subunit A
Neospora caninum NCLIV_004870   DNA gyrase subunit A, putative
Oryza sativa 4334546   Os03g0812000
Plasmodium berghei PBANKA_1438200   DNA gyrase subunit A, putative
Plasmodium falciparum PF3D7_1223300   DNA gyrase subunit A
Plasmodium knowlesi PKNH_1442500   DNA gyrase subunit A, putative
Plasmodium vivax PVX_123795   DNA gyrase subunit A, putative
Plasmodium yoelii PY07326   DNA gyrase subunit a-related
Toxoplasma gondii TGME49_221330   DNA gyrase/topoisomerase IV, A subunit domain-containing protein
Treponema pallidum TP0005   DNA gyrase, subunit A (gyrA)
Theileria parva TP02_0771   DNA gyrase subunit A, putative
Wolbachia endosymbiont of Brugia malayi Wbm0405   DNA gyrase subunit A

Essentiality

PY07326 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2231 Escherichia coli essential goodall
TGME49_221330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Staphylococcus aureus DNA gyrase Compounds References
Mycobacterium smegmatis DNA topoisomerase (ATP-hydrolysing) (Dna gyrase) Compounds References
Escherichia coli DNA gyrase (type II topoisomerase), subunit A Compounds References
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PY07326 (Plasmodium yoelii), DNA gyrase subunit a-related
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