pI: 7.2261 |
Length (AA): 449 |
MW (Da): 49631 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 145 | 5kvm (A) | 36 | 162 | 12.00 | 0 | 0.01 | 0.281861 | -0.04 |
184 | 448 | 3k49 (A) | 521 | 794 | 29.00 | 0 | 1 | 1.0296 | -0.9 |
190 | 441 | 3bwt (A) | 558 | 811 | 39.00 | 0 | 1 | 1.17485 | -1.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129563)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G22240 | protein pumilio 8 |
Arabidopsis thaliana | AT5G56510 | pumilio 12 |
Arabidopsis thaliana | AT1G78160 | pumilio 7 |
Babesia bovis | BBOV_II003300 | pumilio-family RNA binding repeat containing protein |
Candida albicans | CaO19.5381 | relocalize SIR3 and SIR4 from telomere to nucleolus |
Candida albicans | CaO19.12836 | relocalize SIR3 and SIR4 from telomere to nucleolus |
Dictyostelium discoideum | DDB_G0289987 | hypothetical protein |
Entamoeba histolytica | EHI_012320 | pumilio domain-containing protein C6G9.14, putative |
Giardia lamblia | GL50803_17325 | Pumilio-family RNA-binding protein, putative |
Leishmania braziliensis | LbrM.21.1990 | pumillio protein 3, putative |
Leishmania donovani | LdBPK_212050.1 | RNA-binding regulatory protein (pumilio family), putative |
Leishmania infantum | LinJ.21.2050 | pumillio protein 3, putative |
Leishmania major | LmjF.21.1680 | pumillio protein 3, putative |
Leishmania mexicana | LmxM.21.1680 | RNA-binding regulatory protein (pumilio family), putative |
Neospora caninum | NCLIV_026460 | hypothetical protein |
Oryza sativa | 4352241 | Os12g0488900 |
Oryza sativa | 4331909 | Os03g0191700 |
Oryza sativa | 4352254 | Os12g0493900 |
Oryza sativa | 4350783 | Os11g0579900 |
Plasmodium berghei | PBANKA_1233500 | mRNA-binding protein PUF1 |
Plasmodium falciparum | PF3D7_0518700 | mRNA-binding protein PUF1 |
Plasmodium vivax | PVX_080310 | RNA-binding protein, putative |
Plasmodium yoelii | PY04072 | 00806 domains.-related |
Saccharomyces cerevisiae | YGL014W | Puf4p |
Trypanosoma brucei gambiense | Tbg972.10.220 | pumillio RNA binding protein, putative |
Trypanosoma brucei | Tb927.10.310 | pumillio/PUF RNA binding protein 3 |
Trypanosoma congolense | TcIL3000_10_170 | pumillio/PUF RNA binding protein 3 |
Trypanosoma cruzi | TcCLB.468005.9 | pumilio/PUF RNA binding protein 3, putative |
Trypanosoma cruzi | TcCLB.508787.30 | pumilio/PUF RNA binding protein 3, putative |
Toxoplasma gondii | TGME49_260600 | Pumilio-family RNA binding repeat-containing protein |
Theileria parva | TP04_0263 | RNA-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.310 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.310 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.310 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.310 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YGL014W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_260600 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.